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Accutane shortens telomeres ?! damages the DNA ?! Can we heal all Accutane damage with the vitamin A diet?
Hello,
Short question about a big complicated and unexplored topic.
I have often read in the Accutane Facebook groups, akne. org, that Accutane shortens telomeres, damage DNA, damages gene expression, etc.
So the question is, if Accutane really shortens telomeres, for example. Is that due to vitamin A alone? Or does Accutane do more harm than a very strong vitamin A poisoning? In any case, telomeres cannot grow through detoxification, so if it were so, could not all of the damage be remedied?
Study on telomeres and retinoids: https://www.pnas.org/content/98/12/6662
Study on Retinoic acid and cancer treatment /retinoic acid - cytotoxicity: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265016/
Isotretinoin and FoxO1, retinoids effects on the level of gene regulation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219165/
So in summary, is Accutane's damage really full reversible with the vitamin A diet ? Or is it really the same damage as that from severe chronic vitamin A poisoning?
I would be interested in your thoughts, or if someone has specific information,knowledge.
Hi @joel,
Although I don’t have any specific knowledge, I do know that it’s assumed that Accutane can permanently damage the body. No doubt, that is often the case.
However, there’s one Accutane victim who’s been on a low vitamin A diet for about 2+ years now, and he has made pretty good progress in recovering his health. So, there is hope.
Also, I read somewhere that one of the few diets that’s shown to maintain telomeres is an all-meat diet. Sorry, I don’t have references for it.
Accutane is also 5α-Reductase inhibitor. So it is not just like simple vit A toxicity.. It is complicated like post finasteride syndrome.. People report similar issues.. That are completely different like vit A toxicity.. For example collagen, bone loss.. Changes, damage to penis, depression etc..I believe we can get better. But some damage that can't be reversed has been done. Oxidative stress, tissue breakdown, loss of stem cells etc..
This is why I am here. I have post finasteride syndrome from accutane and saw palmetto use. Although others will disagree, I am 100 percent certain this is an autoimmune reaction
Quote from Gari Martin on June 4, 2020, 12:51 pmThis is why I am here. I have post finasteride syndrome from accutane and saw palmetto use. Although others will disagree, I am 100 percent certain this is an autoimmune reaction
What is interesting is that some people can have crazy side effects from just 1 pill.. Like this unfortunate guy https://drive.google.com/file/d/1XCPh-xDhK1e3R-NhS1do5GLAzOlNWLP_/view
I think it has to do something with receptors, their sensitivity or some enzymes and their synthesis or something. It doesn't look like autoimmune issues at all..
@gari what health issues you have? For me the main issues are loss of collagen. So skin, blood vessels, joins, spine. Simply I aged in couple of months at least 20 years.. No wonder I had also a lot of mental issues from that. I was going from doctor to doctor. Everyone looked me like I am completely crazy. It is amazing that I didn't killed myself.. Years of complete nightmare. Now it is better, but I am still far from healthy 33yo guy.. I would love to try long water fast. That should be the best way how to completely "reset" the body. All hormones, enzymes, receptors etc.. to their natural state and once you start eating good diet. Everything should work like before.. But I can't fast. I tried 3 day fast and I was walking death.. Except I couldn't even walk lol.
Quote from Gari Martin on June 4, 2020, 12:51 pmThis is why I am here. I have post finasteride syndrome from accutane and saw palmetto use. Although others will disagree, I am 100 percent certain this is an autoimmune reaction
I agree with you.
@jiri I have every major symptom. I know what the prevailing theory and have read just about every theory ever and have dove head first into the science for years. To me, it’s an obvious autoimmune reaction. This is my opinion on the matter. If you would like me to explain why I can
@puddleduck thanks! Idk how familiar you are with post finasteride syndrome but yeah that’s what I have concluded as well
Quote from Gari Martin on June 5, 2020, 3:37 pm@jiri I have every major symptom. I know what the prevailing theory and have read just about every theory ever and have dove head first into the science for years. To me, it’s an obvious autoimmune reaction. This is my opinion on the matter. If you would like me to explain why I can
@puddleduck thanks! Idk how familiar you are with post finasteride syndrome but yeah that’s what I have concluded as well
Today was the first I had heard of it, and all I read was the Wikipedia entry on finasteride and a symptom list for post-finasteride syndrome. 😛 But I think you are correct, and do not say so flippantly.
A lot of the post-finasteride symptoms are found in CFS/ME, which I believe is primarily caused by neuroinflammation (Jerrod Younger has done some research on this).
When I developed CFS/ME, I had the same psychological/emotional symptoms as seen in post-finasteride syndrome (suicidal depression, anxiety, emotional numbness), which I think are connected to vitamin A toxicity (I became 100% psychologically stable after I unintentionally lowered my vitamin A intake and gained weight, which made more "storage space" for the VA).
Grant has posted some researching linking depression and vitamin A toxicity in this forum not long ago, as well. So yeah, it would make sense that it is all related, and that you are on the right track.