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Supposed cure for Accutane
https://www.reddit.com/r/AccutaneRecovery/
This person believes they have discovered a cure for post accutane syndrome, Lithium. It seems to be working for people.
I agree that lithium has strong therapeutic effects in several diseases including alzheimers as shown by research during the last decade, but its worth keeping in mind that the toxicity dose is also low and that therapeutic dosis are likely to easily become toxic, potentially creating other even more serious problems.
I would recomend upping the sodium intake a lot instead as they act in very similar ways in the body, though sodium has a lower potency obviously. But it compensates by being handled much more safely by the body.
Posts from discussions there:
Sure: Accutane works by killing cells (apoptosis). These cells are in the oily skin glands (sebaceous glands), but in other parts of the body too like the hypothalamus. The mechanism by which Accutane does this is by decreasing a protein called Beta-Catenin. This protein signals for growth, so when it's decreased by Accutane you get cell death. The other thing beta-catenin regulates other than cell death is enzymes that make neurosteroids (brain hormones). This results in a decrease in brain hormones. There's also a direct impact of beta-catenin on the androgen receptor it's further upsetting hormone signalling. I think that's the simplest I can condense it down into, I try to not excessively use scientific terminology in general.
TLDR: The full spectrum of PAS symptoms are explained by changes to the ALDH enzyme family. These enzymes are necessary to produce the retinoic acids endogenously (within the body) from vitamin A consumed through diet. When exogenous (external from the body) retinoic acid is consumed, these enzymes downregulate via a feedback loop of beta-catenin. This homeostatic feedback loop is permanently disrupted explaining the full spectrum of PAS symptoms (from night blindness, to dry eyes, to libido and psychological changes).
Isotretinoin suppresses ALDH enzymatic activity through beta-catenin
He recommends these 3 supplements togehter: High dose Alcar (1g per 10kg Bodyweight), Low dose Lithium Orotate (5-20mg), Liposomal coq10 (200mg)
"The full spectrum of PAS symptoms are explained by changes to the ALDH enzyme family."
Retinoic acid has a short half life in the body. The long term effects of Accutane can be explained by apoptosis (or at least reduction of proliferation) of stem cells and/or progenitor cells as well as epigenetic effects. These effects occur throughout the whole body, many different enzymes are affected.
Furthermore, apoptosis may be the underlying and unifying mechanism of the adverse effects of isotretinoin on neural crest cells (teratogenicity), hippocampal neurones (depression), epidermal keratinocytes and mucosa cells (mucocutaneous side-effects), hair follicle cells (telogen effluvium), intestinal epithelial cells (inflammatory bowel disease), skeletal muscle cells (myalgia and release of creatine kinase), and hepatocytes (release of transaminases and very low-density lipoproteins).
"These enzymes are necessary to produce the retinoic acids endogenously (within the body) from vitamin A consumed through diet. When exogenous (external from the body) retinoic acid is consumed, these enzymes downregulate via a feedback loop of beta-catenin. This homeostatic feedback loop is permanently disrupted explaining the full spectrum of PAS symptoms (from night blindness, to dry eyes, to libido and psychological changes)."
Any references for that?
In Hypervitaminosis A ALDHs and RDHs are producing elevated levels of all trans RA and 13 cis RA meaning elevated levels of RA don't stop these enzymes from continuing to produce elevated levels of RA.
Once someone has long since finished taking Accutane they no longer have elevated levels of retinoic acid (unless they also have Hypervitaminosis A). It's possible that their Xerophthalmia like symptoms are due to impaired vitamin A metabolism but I'm skeptical.
Last week my daughter sent me a video about a spring a few towns away that was considered to be one of those "fountains of youth". In the comments someone mentioned that springs with lithium were thought to be very therapeutic.
Quote from lil chick on November 15, 2023, 6:37 amLast week my daughter sent me a video about a spring a few towns away that was considered to be one of those "fountains of youth". In the comments someone mentioned that springs with lithium were thought to be very therapeutic.
legumes are so calming on me.. I wonder if its their lithium content.
" Legumes, such as lentils, beans and peas
Legumes contain some of the highest amounts of lithium found in food. As I discussed in blog 151, one study showed that legumes were the number one food to live to age 100."
I had no idea what alcar is so I found this explanation:
https://www.webmd.com/vitamins/ai/ingredientmono-834/acetyl-l-carnitine
and I found this:
Can you get carnitine naturally from foods?
Animal-based foods are good sources of carnitine, including:
- Beef, 4 oz cooked - 56-162 mg
- Chicken, 4 oz cooked - 3-5 mg
- Milk, 1 cup whole - 8 mg
- Cheese, 2 oz cheddar - 2 mg
Not mentioned below is heart, which I think might be a good organ for us since I don't think it has VA, but does have lots of coQ10. It tastes like meat.
from the google machine:
"But if you want to boost your CoQ10 levels (and your cardiovascular health), make sure some of these foods are in your weekly diet.
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Organ meats: kidney, liver
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Fatty fish: sardines, salmon, trout, mackerel
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Meats: chicken, beef, pork
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Vegetables: spinach, broccoli, cauliflower
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Fruits: strawberries, oranges
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Oils: soybean and canola oils
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Legumes: soybeans, lentils, peanuts
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Nuts and seeds: pistachio, sesame seeds
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Whole grains"
Tagging the one of latest post about accutane healing theory here from reddit user, for those interested: