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Retinoic acid induces anxiety and depression
If you have ever wondered why you're feeling down, it might be all the retinoic acid which your body is excreting when you're on a low vA-diet. It's my experience at least, and science shows retinoic acid affects the hippocampus of the brain. It's a region responsible for memory formation. This might explain how for some forum members memories seemingly lost return as vA concentration in the blood drops. Half jokingly: In the future, therapists will measure their patient's blood concentration of vA to determine whether or not therapy will be helpful. Why? When vA is the culprit in anxiety and depression, this needs to be dealt with first. Only later when there is better access to old memories will therapy be of any use. If therapy is even necessary then. But let's not go there and assume therapy is another bogus field, as I suggest.
Here's the study on mice that shows clear colerration between retionic acid administration and subsequent behavioral changes in mice.
Clinical reports suggest a potential link between excess retinoids and development of depression. Although it has been shown that all-trans retinoic acid (ATRA) administration induces behavioral changes, further insight into how ATRA is involved is lacking. The hippocampus seems to be a major target of retinoids, and abnormal synaptic plasticity of the hippocampus is involved in depression. We examined two genes associated with synaptic function, discs large homolog 2 (DLG2), and synapse differentiation-inducing gene protein 1 (SynDIG1) in terms of hippocampal expression and correlation with behavior. Three different doses of ATRA were injected into young mice and 10 mg/kg ATRA was found to induce depression-like behavior. In the hippocampus, DLG2 mRNA was significantly decreased by ATRA. mRNA levels were positively correlated with central area duration and distance in the open-field test. Increased SynDIG1 mRNA levels were observed. There was a negative correlation between SynDIG1 mRNA levels and mobility time in the forced swimming test. Retinoic acid receptor γ mRNA was significantly positively correlated with DLG2 and negatively correlated with SynDIG1. To summarize, ATRA administration induced anxiety- and depression-like behavior accompanied by a decreased expression of DLG2 and an increased expression of SynDIG1. Moreover, DLG2 was correlated with anxiety-like behavior and SynDIG1 was correlated with depression-like behavior. These results might constitute a novel target underlying ATRA-induced anxiety- and depression-like behavior.
To me, it starts to look like vA acts like a valve to reality, similar to how Ray Peat argues serotonin acts like a barrier between a person and the experience of reality. As Aldous Huxley expressed:
[He] ... believed that the brain acts as a “reducing valve” that constrains conscious awareness, with mescaline and other hallucinogens inducing psychedelic effects by inhibiting this filtering mechanism.
Now, the one million dollar question: Do psychedelics assist in the depletion of vA?
Very nice observations @christian
In sanskrit truth is named "SAT", which exactly means, what is. This is the 3rd person of the verb "to be".
In Greek, truth is "aletheia", that which has not been forgotten, the substrate of Reality which we tend to forget in our mental divagations and errors. A- LETHEIA, that which has not crossed LETHE, the river of forgetfulness, which washes away memories at death.
Once can easily conceive that at death we are submerged in floods of vitamin A. Stress and al bringing a mighty detox so to speak. Also isn't this a time when we are supposed to remember past experiences of our lives?
At birth too we are submerged with vitamin A with all that milk we have to drink. No wonder there is what is called "infantile amnesia", which wipes away all memories of small children before they are two-three years old.
For the moment I cannot remember so far back.
But who knows? Maybe Grant knows and does not say.
Anyway, I strongly suspect LETHE is full of Vitamin A.
Maybe over the LETHE we can reach to our past lives? Maybe we can erase Original Sin?
If this happens I shall tell you.
Beautiful: river of forgetfulness, which washes away memories at death. Especially in the morning, right after I wake up, my head feels so numb, honestly, I feel really stupid then. Only towards the evening I start to notice what true potential lays beneath that numb, forgetful brain.
In Switzerland, there is a group of doctors who named their organization Aletheia. They are the critical voice who question the necessity of Covid vaccines. They inform earnestly about their side effects and remind everyone how unnecessary vaccines for children are. Their immune system is so robust most of them won't notice much when they've contracted Covid.
In Deuteronomy 34:7 the bible says about Moses: [He] was a hundred and twenty years old when he died, yet his eyes were not weak, and his vitality had not diminished. Maybe living in the desert, sleeping on the ground, and being exposed to the sun day in, day out helped to keep vA levels really low. No floods of vA for him, as he graciously departed his dying body.
Have you noticed any other changes in your life recently in regards to your spiritual experience? You've mentioned somewhere how friends drifted apart, and new people entered your life. How you experience more synchronicities, right? How you were looking for some tool for quite some time, and suddenly it was there (I only remember this story vaguely, I may have mixed up some things).
Thinking about vA from this perspective it can be considered something like a roadblock that hinders the flow of life to pass through you.
Quote from Hermes on October 13, 2022, 6:59 amIf you have ever wondered why you're feeling down, it might be all the retinoic acid which your body is excreting when you're on a low vA-diet. It's my experience at least, and science shows retinoic acid affects the hippocampus of the brain. It's a region responsible for memory formation. This might explain how for some forum members memories seemingly lost return as vA concentration in the blood drops. Half jokingly: In the future, therapists will measure their patient's blood concentration of vA to determine whether or not therapy will be helpful. Why? When vA is the culprit in anxiety and depression, this needs to be dealt with first. Only later when there is better access to old memories will therapy be of any use. If therapy is even necessary then. But let's not go there and assume therapy is another bogus field, as I suggest.
Here's the study on mice that shows clear colerration between retionic acid administration and subsequent behavioral changes in mice.
Clinical reports suggest a potential link between excess retinoids and development of depression. Although it has been shown that all-trans retinoic acid (ATRA) administration induces behavioral changes, further insight into how ATRA is involved is lacking. The hippocampus seems to be a major target of retinoids, and abnormal synaptic plasticity of the hippocampus is involved in depression. We examined two genes associated with synaptic function, discs large homolog 2 (DLG2), and synapse differentiation-inducing gene protein 1 (SynDIG1) in terms of hippocampal expression and correlation with behavior. Three different doses of ATRA were injected into young mice and 10 mg/kg ATRA was found to induce depression-like behavior. In the hippocampus, DLG2 mRNA was significantly decreased by ATRA. mRNA levels were positively correlated with central area duration and distance in the open-field test. Increased SynDIG1 mRNA levels were observed. There was a negative correlation between SynDIG1 mRNA levels and mobility time in the forced swimming test. Retinoic acid receptor γ mRNA was significantly positively correlated with DLG2 and negatively correlated with SynDIG1. To summarize, ATRA administration induced anxiety- and depression-like behavior accompanied by a decreased expression of DLG2 and an increased expression of SynDIG1. Moreover, DLG2 was correlated with anxiety-like behavior and SynDIG1 was correlated with depression-like behavior. These results might constitute a novel target underlying ATRA-induced anxiety- and depression-like behavior.
To me, it starts to look like vA acts like a valve to reality, similar to how Ray Peat argues serotonin acts like a barrier between a person and the experience of reality. As Aldous Huxley expressed:
[He] ... believed that the brain acts as a “reducing valve” that constrains conscious awareness, with mescaline and other hallucinogens inducing psychedelic effects by inhibiting this filtering mechanism.
Now, the one million dollar question: Do psychedelics assist in the depletion of vA?
and nothing gets rid of it faster than a 30 mins HIT workout . Personal anecdote .I think it does something where the concentration of RA more in the blood and moves it around in the body
Another thing that comes to mind: Heat exposure like saunas supports the detox process too.
I would say I have selective memory loss. I tend to forget anything that's not important to remember. I forget very little that concerns my job, and since I'm running a small business I have a lot of things to keep in mind in that regard. On the other hand, I tend to forget what I did last weekend, the plots of movies I watched recently or books I ready recently. My mind is wiped clean more or less quickly.
I believe the storage of memories has to do with emotion, and emotions are signs of energetic blockages. The stronger an emotion the more memories about the situation are stored. An ex gf of mine is very emotional and she recalls conversations we had a year ago almost verbatim. Now, I've been removing energetic blockages in this body for almost a decade, anything that I can find or that intuition leads me to, and the more blockages I removed the calmer but also the less emotional I became, to the point where almost nothing triggers me anymore. So memories are created sparingly and I live mostly in the moment, as the saying goes.
Also, I think very little unless I have to. The "voices in my head" are silent most of the time. And I don't dream, or if I dream, I don't remember it, and if I do remember it then it's not colourful real-life dreams but only a sort of knowing what was dreamt but no images.
I also don't see anything when I close my eyes and imagine things, so I don't usually imagine. This could be related to a calcified pineal gland. However, I'm very energy sensitive both locally and non-locally and have only just come across a good way to harmonize EM radiation that bothered me a lot in the past.
Anyway, I'll keep watching what develops on this vA diet but I think it's definitely a good thing. Since about 15 years I'm on a winding path to an interesting new state of human development and eliminating plants and vA from the diet is one piece of a gigantic puzzle that keeps growing.
Quote from Carnivore on October 14, 2022, 5:52 amI would say I have selective memory loss. I tend to forget anything that's not important to remember. I forget very little that concerns my job, and since I'm running a small business I have a lot of things to keep in mind in that regard. On the other hand, I tend to forget what I did last weekend, the plots of movies I watched recently or books I ready recently. My mind is wiped clean more or less quickly.
This is an interesting observation. Not sure what to make of it. I can only contribute to say there's lots of missing memories from my childhood. I really think my long-term memory is not in a great shape, especially when I compare it to friends some of which remember books, movies, events long passed. And I'm always left wondering, why can't I remember such things in this vividness? For me, I can't really distinguish between private and work-related information. I'm convinced that vA excess is contributing to poor memory recall. There are even studies suggesting behavioral improvements in kids when they go on a low vA diet. Improved ADHD symptoms and so forth. And by any means, kids will always have lower levels of vA than adults, on average. So if kids improve on a low vA diet, just imagine the mileage of adults. I expect my memory to improve considering that data.
I believe the storage of memories has to do with emotion, and emotions are signs of energetic blockages. The stronger an emotion the more memories about the situation are stored. An ex gf of mine is very emotional and she recalls conversations we had a year ago almost verbatim. Now, I've been removing energetic blockages in this body for almost a decade, anything that I can find or that intuition leads me to, and the more blockages I removed the calmer but also the less emotional I became, to the point where almost nothing triggers me anymore. So memories are created sparingly and I live mostly in the moment, as the saying goes.
Hm, interesting idea about energy blockages. If an event triggers strong emotions, more than is natural, it's a good indicator of unresolved issues. Now, I also think those blockages can hinder experiencing positive emotions which would help remember an event, a movie and so forth. Not sure if my goal is to strive for a stoical personality. I think I would like to be able to tune in with precision to the emotions of people around me. This would also be helpful in building good relationships. Mind you, it's also a skill not to be sucked into the drama of other people. That's not what I mean. I rather mean being able to pick up subtle clues. It doesn't help when you feel like your brain-dead half the time. Also, in this regard I expect improvement.
What have you found most helpful in removing energy blockages, as you describe them? I keep wondering about this marvelous human experience where there is really no clear-cut boarder between mind, body, and soul. And I like to look at things from different angles. Vitamin A is obviously one big puzzle piece, but what are the others? For me, certainly faith has become an important factor too.
Also, I think very little unless I have to. The "voices in my head" are silent most of the time. And I don't dream, or if I dream, I don't remember it, and if I do remember it then it's not colourful real-life dreams but only a sort of knowing what was dreamt but no images.
Yeah, I can relate to the voices in the head idea. They've become less prominent, and it seems as if I have more control over them, which is really helpful. I do dream but quickly forget the weird images and impressions again, rarely do I have any extended stories narrated in my dreams like some people experience.
I also don't see anything when I close my eyes and imagine things, so I don't usually imagine. This could be related to a calcified pineal gland. However, I'm very energy sensitive both locally and non-locally and have only just come across a good way to harmonize EM radiation that bothered me a lot in the past.
My imagination can be pretty wild. That's certainly something that's working in my favour. I'm just reading a Christian book on the importance of imagination, which is really helpful in realizing the life you want.
I'm curious about your efforts to harmonize EM radiation. What are you doing that's helpful to you? The only things I do: I have my phone in airplane mode most of the time and don't use wifi at home, instead, I use an ethernet cable to connect my laptop.
@christian I think everything has to do with the ability of the body to adjust to its environment. It makes things bearable that might otherwise become unbearable eventually. Think of prison inmates who don't want to leave prison after a decade or two because they got so used to their imprisonment and limited environment that they are afraid of going outside. It's the same with animals. The body adjusts to everything in every possible way. So something selective memory loss is a good thing if one is exposed to a lot of information that has to be kept in mind where other, unrelated information would interfere with optimal performance. It's just blanked out because the mind considers it unimportant. Thus people can become either head-centered, heart-centered or loin-centered depending on their needs. None of it is better or worse, it just is what it is.
As regards emotions, in my current view emotions are always a sign of blockages and the more negative an emotion the stronger the blockage. No emotions, meaning no blockages, would be a state of pure bliss and all-encompassing love which is the basis of everything. Anything that limits this state blocks a part of the full energy potential. It manifests in the mind as a thought, in the astral body as an emotion, and in the physical body as some sort of physical symptom, low energy state or imbalance.
That said, I'm not implaying that I have reached a state of bliss or anything of the sort, nor what one might call enlightenment. I think the relative absence of emotions in my case comes from the very limited amount of change in my life during the past 10 or 15 years, and the strong focus on thought, making me a very head-centered person by necessity. I'm currently changing that by putting part of my focus elsewhere, as a sort of experiment. For me it's still all about understanding life and how everything works but maybe I'll come to cherish it again, too, not just analyze it.
Despite the head-centeredness I've developed a strong energetic sensitivity that allows me to feel blockages in myself and others (also non-locally since all is one), and focus on those blockages without intention removes them. Unintentionality is important because the intention to remove something manifests or strengthens that very thing. I just keep my mind focused on what I perceive as blockage until it goes away. I feel this in my body as energy flow.
The drawback of such a sensitivity is that one is very open to all energies and easily takes up problems of people one is in regular contact with. You become almost like a mirror. I've had strange, unrelated health issues, certain minor personality changes or different interests depending on which girlfriend I was together with over the years.
Over time I developed a state of relative equanimity in the face of everything, be it health related or other. So I see this whole vA thing as just a minor issue that has to be dealt with at the moment but is just a symptom of an overall change in life that's currently taking place, also symbolized by certain planetary aspects in my horoscope. Everything is just a symbol because life is a dream. Interpreting the symbols and finding meaning has become a hobby. Looking back, everything that happened has happened for me to incorporate it into the book I'm currently writing (or being lead to write) which is primarily about health but also has many spiritual aspects. It's like a gigantic puzzle with many seemingly unrelated pieces that nonetheless fit together, but only in hindsight. That's life.
About the harmonization of EM radiation, I highly recommend VitaChip. These tiny things work wonders and are relatively inexpensive.
"I highly recommend VitaChip"
Wow...just...wow... The world's most expensive sticker. Pairs nicely with the world's most expensive paperweight.