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80 years old: and it's working ! !
I'm 80 years old and brand new to all of this.
Started vAe three days ago.
Reading the books as fast as I can, but decided to start doing even before finished reading.
Didn't expect much.
80 years of eating milk and cheese and ice cream, plus liverwurst sandwiches and vegetables and salmon, and, and, and.
But I thought, too late for me.
I was wrong about that.
Just three days and easy to see the start of positive changes in energy, mood, mental focus, sleep, and attitude toward life.
If this much positive change is happening this fast at this age, I wonder what it might be like in 10 years, at age 90.
Or, 10 years after that.
- Larry
(writing from Bangkok, Thailand)
Hi Larry! That is pretty cool. Please do keep us informed.
I do think things are different for us older people, but we ain't dead yet.
I was always amazed at my grandmother in her 90's and what her body could still overcome, things like flu, moving house or whatever.
Nice to read @larry-2
Might merit a warning here. Slowing down and or stopping intox feels good. At some point liver senses the go signal and starts detoxing all those toxins you took in before now. As Garrett Smith says, poison on the way in, poison on the way out. It is going to hurt as much or more as the liver dumps out the toxins as it hurt on the way in when you still took in those toxins. That is where learning to get the rest of our systems up to speed to keep up with excreting out of the body what the liver is excreting into the body.
Look forward to seeing you around here and on nutritiondetective.com.
Good on ya. See you around.
You might be starting out to hard and self-intoxicating yourself. Starting low and slow is THE best general approach of adding or removing things. Many toxins are stimulatory — retinoic acid is well-known to overly increase cell-turnover in stem-cells for the short-term but that is also a reason for the following long-term damage by depleting stem-cell. Just look at Accutane (13-cis-retinoic acid) as an example of this effect both on the short- and long-term.
For more on self-intoxitification by retinoids see any of Anthony R. Mawson's paper for more information on endogenous toxicity of retinoids, like for example his 2021 paper:
"Liver Damage and Exposure to Toxic Concentrations of Endogenous Retinoids in the Pathogenesis of COVID-19 Disease: Hypothesis"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392079/
Perhaps you can look at this 2021 thread started by Grant Genereux called "A Best Practices Diet" for some thoughts on different approaches and I think you will see that there doesn't exist an one-size fits all approach:
https://ggenereux.blog/discussion/topic/a-best-practices-diet/
Quote from Joe on October 27, 2023, 3:07 pmNice to read @larry-2
warning ... As Garrett Smith says, poison on the way in, poison on the way out. It is going to hurt
Thank you very much @Joe.
That sort of advice is exactly what I need.
- Larry
Quote from David on October 27, 2023, 8:24 pmYou might be starting out too hard and self-intoxicating yourself. Starting low and slow is THE best general approach of adding or removing things. /
@David - I appreciate very much your "Early Warning" and the links you posted.
- Larry
Good on ya Larry.
Liver wants to detox. No need to push it. First goal is to pace the process to minimize the pain on the way out. Garrett has good threads on twitter. If Twitter seems like a reach consider how old many of us spring chicks are on here (and there).
By popular demand…
Here are my “Best of the Best” threads that expose…
The dangers of “vitamins”
The problem with “health foods”
The poisons being sold as “essential”Plus, discover a few ways to start slowly turning your health around today!
Happy reading!
— Nutrition Detective 🔍 - Dr. Garrett Smith (@NutriDetect) August 14, 2022
Garrett also has great threads on his Love Your Liver (LYL) network on nutritiondetective.com. That is like $100/yr. Lifetime membership is included when you sign on to his consult program. These links are helpful for his help as well as consulting with a larger group of folks going through similar issues. Similar to this blog except that Garrett and Nathan are clinicians intent on guiding the network to keep us going forward while minimizing bickering. Ad hominem does not fly there. Most of the time it just takes reminding us that all of our symptoms and their solutions will differ as all of our genetics and experiences are vastly different.
His livestream meets every Monday at noon CST I think. Time change is coming and cannot remember when he usually starts. When I miss the 2 hr livestream I catch it later to listen and read through the chats.
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ps://www.you
tube.com/watch?v=Y2fNwCaW-Bs&t=1s
Had to break the link above. For some reason Youtube was not letting the link work. Please cut and paste without the breaks to your browser to take a look.
This was last Monday. It is nice to be able to get questions answered directly on the livestream when we send him a message on superchat. It is also nice to get answers from other folks on the live chat.
He also has zoom calls for higher priced packages. Last I heard Grant joins in on those zoom calls once every month or two (I think). Have not caught him on one of those yet. If for no other reason those zoom calls are nicer because we do not need to worry about youtube censoring us.
One of our newer younger members wrote this up recently. Simple and short. Hope it helps. Her article helped me even though I am a few months ahead of her on this trip. Kid grokked it well.
(2) Formulating a Low Vitamin A Diet - Emily Antiqua (substack.com)
What I love best about Garrett's livestreams and zoom calls is that whatever the question is he or one of us will follow each question with links to pubmed studies or other articles backing and clarifying. For me when I started my worst symptom was sacroiliitis. Lived crouched over a walker or kitchen counter from 11/21/2022 until 4/15/2023.
In December, 2022 my interwebs searches got me to Garrett and Grant interviews with Judy Cho's youtube channel Nutrition With Judy. It looked like they might be able to help me. Got hold of Garrett on a chat and asked questions looking for proof that he had any clue what was going on with me and how to fix it. He seemed too confident in our first interactions so I called him out on it. Told him if he was so confident he could cut my pain so easily, he should be able to get me some papers to read on topic in a day or two. 20 seconds later he zapped me a link to a search on "isotretinoin sacroiliitis" and sent me
https://pubmed.ncbi.nlm.nih.gov/31765029/
and let me know there were plenty more like it on his google results.
Kinda p-------d me off. Said alright, well then if it is so simple, then you have a client that you fixed this for that I can talk to. 20 seconds later he sent me a link to a guy in Michigan went through the same thing 8 months ahead of me. Ten minutes later I talked with that guy and got more ideas. Got back to Garrett and since then he (and others on the network) have helped me figure out each new step as I go forward. Pain is down 99% and rest of the symptoms are working out as well.
Garrett probably posts links to 10 to 25 studies and science papers every week. Reading all these gets easier as we go. More importantly doing our own searches for pertinent papers gets easier too. Everyone is so different we all need to make up our own plan, experiment, adjust and remake our own plan. Garrett and Nathan (his PA) are willing to help with ideas and warnings. In the end, the risks and results are on each of us. Looking forward to seeing you soon on one of these networks.
Meanwhile keep on and go slow.
@david wrote:
For more on self-intoxitification by retinoids see any of Anthony R. Mawson's paper for more information on endogenous toxicity of retinoids, like for example his 2021 paper:
"Liver Damage and Exposure to Toxic Concentrations of Endogenous Retinoids in the Pathogenesis of COVID-19 Disease: Hypothesis"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392079/
Building on these observations, we propose that infection-induced activation of the retinoid cascade triggers cell-mediated apoptotic hepatitis, leading to transient cholestatic liver dysfunction, in which stored vitamin A compounds (retinyl esters and the metabolite retinoic acid) enter the circulation through damaged bile ducts and hepatocytes; this exposure can in turn cause lung injury and other organ damage by apoptosis, necrosis, and acute neutrophilic infiltration (21). On this hypothesis, an endogenous form of retinoid toxicity contributes to the multiple signs and symptoms of COVID-19, and disease severity is directly proportional to the concentration of circulating retinyl esters and retinoic acid.
The retinoid cascade leads to elevated ATRA levels stimulating fibroblast collagenase release. Increased proline hydroxylation could quickly lead to Hypovitaminosis C. One of the enzymes involved in bile acid synthesis from cholesterol cholesterol 7 alpha-hydroxylase is ascorbate dependent. So this cascade could also contribute to the transient cholestasis Mawson is speculating occurs during COVID-19.
This may be a primary reason why vitamin C helps during infection, by assisting in preventing a transient reduction of retinoid excretion in bile during infection.
That is interesting, Tim. I think several of us have had some bad or odd or overblown reactions to normal, every day germs. I'm trying to get over something right now, maybe I'll chop up that pineapple on the counter for lunch. Last night I really kind of felt like I was histamined-out, and if I think about it, I have read that vitamin C helps with histamine. Maybe my C reserves are low.