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A or D supplements may increase ACE2, Covid19 risk
Quote from
dan on March 23, 2020, 8:59 am
Despite generally recommending Vitamin A supplementation, nutrition researcher Chris Masterjohn is
now recommending against supplementing Vitamin A and D because "they could increase ACE2, the protein that [Covid-19] uses to enter cells." Here are excerpts from his
$10 PDF :
- "Most coronaviruses whose entry method is well established dock to aminopeptidase N... [4]. SARS-CoV and SARS-CoV-2, by contrast, dock to angiotensin-converting enzyme-2 (ACE2) [5,6]" (SARS-CoV-2 is the virus that causes COVID-19 disease)
-
"[Vitamin A's] active metabolite, all-trans retinoic acid, has been shown to upregulate ACE2 in the heart of rats whose blood pressure was raised by constricting their aortas [64], in the heart and kidney of spontaneously hypertensive rats [65], in the kidney of rats with glomerular sclerosis (to much higher levels than even healthy control rats), [66] and in rat tubular epithelial cells subject to hypoxia-repurfusion. [67]"
-
"Calcitriol, the active metabolite of vitamin D, increases ACE2 mRNA and protein in rat pulmonary microvascular endothelial cells treated with lipopolysaccharide, [71] synergizes with diabetes to increase ACE2 protein in the renal tubules of rats, [72] and in the brains of both hypertensive and healthy rats. [73]"
Despite generally recommending Vitamin A supplementation, nutrition researcher Chris Masterjohn is
now recommending against supplementing Vitamin A and D because "they could increase ACE2, the protein that [Covid-19] uses to enter cells." Here are excerpts from his
$10 PDF :
- "Most coronaviruses whose entry method is well established dock to aminopeptidase N... [4]. SARS-CoV and SARS-CoV-2, by contrast, dock to angiotensin-converting enzyme-2 (ACE2) [5,6]" (SARS-CoV-2 is the virus that causes COVID-19 disease)
-
"[Vitamin A's] active metabolite, all-trans retinoic acid, has been shown to upregulate ACE2 in the heart of rats whose blood pressure was raised by constricting their aortas [64], in the heart and kidney of spontaneously hypertensive rats [65], in the kidney of rats with glomerular sclerosis (to much higher levels than even healthy control rats), [66] and in rat tubular epithelial cells subject to hypoxia-repurfusion. [67]"
-
"Calcitriol, the active metabolite of vitamin D, increases ACE2 mRNA and protein in rat pulmonary microvascular endothelial cells treated with lipopolysaccharide, [71] synergizes with diabetes to increase ACE2 protein in the renal tubules of rats, [72] and in the brains of both hypertensive and healthy rats. [73]"
puddleduck has reacted to this post.
Quote from
ggenereux on March 23, 2020, 9:16 am
Hi @dan,
Here's an another interesting reference:
So, to me it looks like elevated levels of vA could be a factor in why older people are more vulnerable. Of course, this is well documented in other studies that vitamin A weakens cell membranes and therefore enable a much faster rate of viral replication.
Hi @dan,
Here's an another interesting reference:
So, to me it looks like elevated levels of vA could be a factor in why older people are more vulnerable. Of course, this is well documented in other studies that vitamin A weakens cell membranes and therefore enable a much faster rate of viral replication.
puddleduck and Judy have reacted to this post.
Quote from
dan on March 23, 2020, 9:18 am
For Covid19 prevention, my former naturopath is recommending 25,000iu/day of Vitamin A -- "if active infection can double this dosage" -- and 50,000 IU/week Vitamin D -- "If you get an active sickness, double the dose for two weeks."
I'm quite annoyed at him because I'm fairly certain that taking Vitamin A and D on his advice personally hurt me and likely many other patients (his practice is very busy and expensive). However, he courteously responded to me when I asked him to respond to Masterjohn's concerns. So I'm posting it below to show his reasoning. The numbering and bold has been added by me:
- "This topic has already come up with ACE HTN medicines and is a complex topic."
- "My main goal is prevent spread, arrest viral replication (where the zinc comes in) and attenuate inflammatory cytokine storms trigger need for hospital bed and ventilator ."
- "A and D bolster mucosal immunity so Virus 'breach' is dampened, are both anti-viral in the literature, modulate corona's trigger of innate immune response (the problem for those who die from ARDS."
- "A, D mechanisms very multi-factorial and sure I'd love them to not interact with ACE2, but boy have they prevented hospitalizations in Influenza, COPD and asthma in my years."
- "Upregulation of ACE 2 receptor sites does not evidence breach and using an LPS (Lipopolysaccharides from bacterial endotoxin-think E.Coli endotoxin-how you trigger leaky linings in rat model) for driving leaky borders."
- "A literature search on 'Vitamin A and virus' is an interesting read in regards to Vitamin A deficiency and Respiratory tract infections damage,"
- "this recent study under peer review but well referenced with human epidemiological studies on D and enveloped viruses is also a good read."
- "Really wish we had large scale trials to understand the multifactorial angles on corona, but also think masterjohn...although sharp is making some jumps."
- "Although we get very mild reduction of BP with Vitamin D, its nothing like giving an ACE on Bp numbers."
For Covid19 prevention, my former naturopath is recommending 25,000iu/day of Vitamin A -- "if active infection can double this dosage" -- and 50,000 IU/week Vitamin D -- "If you get an active sickness, double the dose for two weeks."
I'm quite annoyed at him because I'm fairly certain that taking Vitamin A and D on his advice personally hurt me and likely many other patients (his practice is very busy and expensive). However, he courteously responded to me when I asked him to respond to Masterjohn's concerns. So I'm posting it below to show his reasoning. The numbering and bold has been added by me:
- "This topic has already come up with ACE HTN medicines and is a complex topic."
- "My main goal is prevent spread, arrest viral replication (where the zinc comes in) and attenuate inflammatory cytokine storms trigger need for hospital bed and ventilator ."
- "A and D bolster mucosal immunity so Virus 'breach' is dampened, are both anti-viral in the literature, modulate corona's trigger of innate immune response (the problem for those who die from ARDS."
- "A, D mechanisms very multi-factorial and sure I'd love them to not interact with ACE2, but boy have they prevented hospitalizations in Influenza, COPD and asthma in my years."
- "Upregulation of ACE 2 receptor sites does not evidence breach and using an LPS (Lipopolysaccharides from bacterial endotoxin-think E.Coli endotoxin-how you trigger leaky linings in rat model) for driving leaky borders."
- "A literature search on 'Vitamin A and virus' is an interesting read in regards to Vitamin A deficiency and Respiratory tract infections damage,"
- "this recent study under peer review but well referenced with human epidemiological studies on D and enveloped viruses is also a good read."
- "Really wish we had large scale trials to understand the multifactorial angles on corona, but also think masterjohn...although sharp is making some jumps."
- "Although we get very mild reduction of BP with Vitamin D, its nothing like giving an ACE on Bp numbers."
puddleduck has reacted to this post.
Quote from
Jiří on March 23, 2020, 9:23 am
I think to have bioavailable copper is also very important. I have low ceruloplasmin for years + low vit D I am basically already dead..
I think to have bioavailable copper is also very important. I have low ceruloplasmin for years + low vit D I am basically already dead..
puddleduck has reacted to this post.
