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Adipose Tissue/RBPs
I was reading some of Grant's older posts about retinol binding proteins (RBP) being antibodies and that made sense. I agree that adipose tissue increases production of RBPs in an attempt to neutralize the increase of vitamin A in the blood stream. It got me thinking that reducing adipose tissue too quickly may be much more counterproductive than I may have initially thought.
I always thought that it was best to bite the bullet and reset my body by stripping down "unnecessary" adipose tissue. I thought I would be speeding up the process, taking it on the chin if by increasing my immune response, if it meant a quicker recovery. What if by doing so, I only dragged it out and made things harder? What if, by stripping away adipose tissue, I not only released VA stores but also hampered by body's ability to create antibodies to the poison itself, leaving VA unbound and provoking more problems? After all, the worst symptoms were always after times of dropping from 180lbs down to 150lbs. I have even been down to 130lbs in an attempt to speed up recovery. Seems like it just made symptoms worse and didn't speed anything up.
This thread had some interesting ideas about fat deposit and carotenoids. I do wonder where the copious amount of carotenoids were/went when I was 130lbs and eating sweet potatoes everyday if they weren't in fat stores.
https://ggenereux.blog/discussion/topic/why-a-detox-could-take-years-fat-biopsy/
Just some thoughts
Armin said: "I do wonder where the copious amount of carotenoids were/went ... if they weren't in fat stores"
Yah. Perhaps this is really the answer to why weight loss is so tricky and gain is so mysterious. I'm guessing that isn't the only place VA's hide, but I think being able to put on adipose is a survival "skill" and I wonder if that is how people end up on that show "my 600 pound life".
Hubs rarely looses weight but mine is up and down and I'm more symptomy. Hubs has never gone super low VA so I don't know if that holds him back from loosing weight.
I've often stood in line at the big box store and looked around at people who have horrible weight problems-- but don't seem to have the horrible skin problems that I fight.
I've mentioned "Butter Bob" who was an online weight loss guru, one of those feel-good stories, until he came down with an awful case of vertigo and disappeared from the web.
I noticed that people on my 600 pounds life, after loosing weight, end up with thick glasses, obviously the vA freed from their fat hurts their eyes.
VA is mainly stored in the liver, there pufa/carotenoids are rather released.
Quote from Даниил on August 21, 2021, 3:28 amVA is mainly stored in the liver, there pufa/carotenoids are rather released.
When someone crash diets or loses 30 pounds potentially full of carotenoids, where do you think they go? Do they not have a safe landing point or circulate until they are converted to retinol and then stored as retinol, where ever they can find a home? Where could carotenoids be stored if there is no fat available?
They enter the bloodstream and are oxidized / converted into VA.
Quote from Armin on August 21, 2021, 9:50 amQuote from Даниил on August 21, 2021, 3:28 amVA is mainly stored in the liver, there pufa/carotenoids are rather released.
When someone crash diets or loses 30 pounds potentially full of carotenoids, where do you think they go? Do they not have a safe landing point or circulate until they are converted to retinol and then stored as retinol, where ever they can find a home? Where could carotenoids be stored if there is no fat available?
Quote from Даниил on August 21, 2021, 1:37 pmThey enter the bloodstream and are oxidized / converted into VA.
Quote from Armin on August 21, 2021, 9:50 amQuote from Даниил on August 21, 2021, 3:28 amVA is mainly stored in the liver, there pufa/carotenoids are rather released.
When someone crash diets or loses 30 pounds potentially full of carotenoids, where do you think they go? Do they not have a safe landing point or circulate until they are converted to retinol and then stored as retinol, where ever they can find a home? Where could carotenoids be stored if there is no fat available?
So the increased immune response/inflammation is not necessarily just the immune system being more functional but also taking on a higher work load? Losing 30 pounds these last few months probably not the best route to take but what's done is done. 🙁
I appreciate these questions, @armin, and I would like to know the answers, also.
My weight loss during the low-vitamin A was slow and steady and without side effects while I was eating high/unrestricted calories. Then I hit a rough patch with insomnia and low appetite this winter, at which point my skin looked like a deflated ballon and I felt frail. I have gained weight since then (not much) about ten or fifteen pounds or so, but it has made all the difference.
Having a small roll of belly fat seems to be helpful for some reason. 😂
It puzzles me why some people who have been doing the low-vitamin-A diet quite religiously for a year or two haven’t lost any weight at all (and in some cases, gained weight).
Many years ago when I was underweight, I ate loads of SWEET * potatoes, too. It worsened the mental illness I had at the time, and makes me wonder if the caratenoids weren’t being stored in the brain.
*ETA: neglected to specify it wasn’t white potatoes, but orange sweet potatoes. 😵 🍠