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Alcohol and Vitamin A metabolism

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Found this really interesting as I am suffering from periodic blurred vision and have a retinol level of 3.0. The day after I consume alcohol my vision is pin sharp. My blood sugar is lower @ 5.2 which could explain it, however, I would not say my blood sugar is excessively high when I don't take alcohol  @ 5.9. Having come off keto I am still consuming fatty meat and I do notice that high fat meals do increase blurring regardless of vitamin A. I believe I recall reading that fat mobilises retinol? If it's not the lower blood sugar improving my vision surely it is retinol reduction??

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367262/

I get blurred vision when I eat VA. Fatty meat has significant amounts of VA in it, that's probably why you're getting that reaction. My advice to you would be to eat the least fatty meat you can buy and to use either MCT or a clear sunflower oil as your fat. 

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Neilky

alcohol, higher doses of vit D, and when I first started low VA all made my vision pin sharp as well.

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Neilky
Quote from salt on September 28, 2019, 5:05 pm

I get blurred vision when I eat VA. Fatty meat has significant amounts of VA in it, that's probably why you're getting that reaction. My advice to you would be to eat the least fatty meat you can buy and to use either MCT or a clear sunflower oil as your fat. 

Great to hear someone else has experienced the same! I couldn't get to the bottom of it but I think the dots are starting to join up. Is beef fat not safe then? Thanks for posting.

Quote from tar on September 28, 2019, 10:10 pm

alcohol, higher doses of vit D, and when I first started low VA all made my vision pin sharp as well.

Uncanny! Hard to believe that dangers of vitamin A aren't more widely known. I also had peeling lips for months which was unexplained.

Keto is perfect for Vit A toxicity, there are hoards of people finding success on it but most are doing it to lose weight. I was doing it for autoimmune so was eating nearly a stick of butter, liver, ton of bacon, an avocado and a minimum of 3 eggs a  day to hold weight.

Quote from tar on September 28, 2019, 10:10 pm

alcohol, higher doses of vit D, and when I first started low VA all made my vision pin sharp as well.

@tar

How long did it take for your vision to restore on this diet? I feel mine is getting better but it is slow.

Quote from Neilky on October 9, 2019, 5:38 am
Quote from tar on September 28, 2019, 10:10 pm

alcohol, higher doses of vit D, and when I first started low VA all made my vision pin sharp as well.

@tar

How long did it take for your vision to restore on this diet? I feel mine is getting better but it is slow.

My vision is not restored, but it gets better under the above conditions.  I will say I think it has become a bit better since starting the diet.  It got WAY better for awhile, and then went back to being slightly better then normal.

@neilky I also had this problem for years. I would see a much crisper image after a glass of alcohol and eating fat would make my eyesight blurry.

It went from bad to worse for years. I feel I have found this Vitamin A reason for it. After 4 et a half months on the zoo A diet, n I don't see better yet BUT it has stopped getting worse.

Fingers crossed. Are you getting better?

Quote from Neilky on September 28, 2019, 8:55 am

Found this really interesting as I am suffering from periodic blurred vision and have a retinol level of 3.0. The day after I consume alcohol my vision is pin sharp. My blood sugar is lower @ 5.2 which could explain it, however, I would not say my blood sugar is excessively high when I don't take alcohol  @ 5.9. Having come off keto I am still consuming fatty meat and I do notice that high fat meals do increase blurring regardless of vitamin A. I believe I recall reading that fat mobilises retinol? If it's not the lower blood sugar improving my vision surely it is retinol reduction??

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367262/

"Despite the evidence of depleted hepatic retinoid content in chronic alcoholics, it remains to be established whether dietary vitamin A supplementation would have a beneficial effect on liver pathology. Conflicting results have been published on the effect of vitamin A supplementation to rats chronically consuming alcohol, with one group reporting an enhancement of liver injury (increased lipid accumulation and increased indicators of steatohepatitis) [32,33]"

lol

Quote from Даниил on August 2, 2021, 9:39 am
Quote from Neilky on September 28, 2019, 8:55 am

Found this really interesting as I am suffering from periodic blurred vision and have a retinol level of 3.0. The day after I consume alcohol my vision is pin sharp. My blood sugar is lower @ 5.2 which could explain it, however, I would not say my blood sugar is excessively high when I don't take alcohol  @ 5.9. Having come off keto I am still consuming fatty meat and I do notice that high fat meals do increase blurring regardless of vitamin A. I believe I recall reading that fat mobilises retinol? If it's not the lower blood sugar improving my vision surely it is retinol reduction??

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367262/

"Despite the evidence of depleted hepatic retinoid content in chronic alcoholics, it remains to be established whether dietary vitamin A supplementation would have a beneficial effect on liver pathology. Conflicting results have been published on the effect of vitamin A supplementation to rats chronically consuming alcohol, with one group reporting an enhancement of liver injury (increased lipid accumulation and increased indicators of steatohepatitis) [32,33]"

lol

lol indeed.

Interesting that chronic alcohol consumption bottoms out VA content. Pretty much confirms that alcohol consumption upregulates the ALDH and ADH levels and facilitates removal of VA.

I wonder if retynl esters can be removed via bile excretion

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