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Biotransformation of retinol finally revealed

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https://ggenereux.blog/discussion/topic/teen-goes-blind-from-kfc-coke/

I noticed that in one of the photos of the child with vitamin A deficiency he had acne. As far as I know acne is common is countries with low vitamin A consumption. It seems very likely though that depleting vitamin A levels if one has Hypervitaminosis A will result in improved liver health and overall health resulting in less acne. Acne is primarily a hormonal issue so anything that causes improved hormonal balance and regulation will tend to improve it. Hypervitaminosis A causes insulin resistance so that is one way in which it can cause hair loss, hirsutism and acne. A lot of the harm of Hypervitaminosis A occurs through indirect effects. Think vitamin deficiencies, enzyme inhibition, insulin resistance, liver dysfunction, hormone imbalance.

Quote from tim on October 21, 2021, 2:31 am

https://ggenereux.blog/discussion/topic/teen-goes-blind-from-kfc-coke/

I noticed that in one of the photos of the child with vitamin A deficiency he had acne. As far as I know acne is common is countries with low vitamin A consumption. It seems very likely though that depleting vitamin A levels if one has Hypervitaminosis A will result in improved liver health and overall health resulting in less acne. Acne is primarily a hormonal issue so anything that causes improved hormonal balance and regulation will tend to improve it. Hypervitaminosis A causes insulin resistance so that is one way in which it can cause hair loss, hirsutism and acne. A lot of the harm of Hypervitaminosis A occurs through indirect effects. Think vitamin deficiencies, enzyme inhibition, insulin resistance, liver dysfunction, hormone imbalance.

I don't agree with that. In my experience, acne is common in developed countries where people eat a lot of VA. For example, I was in Thailand, and I didn't see any pimples there. Of course, you can blame it the sun, good ecology... Btw, they eat mostly white fruits, with the exception of papayas. The fact that milk causes acne is a well-known and scientifically confirmed.

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC6115795/

VA (in the form of retinol acetate) did not help me solve the problem of acne.

@daniil

There is plenty of acne in Thailand. Also, milk isn't high in vitamin A.

PREVALENCE AND ASSOCIATED FACTORS OF ACNE VULGARIS AMONG HIGH SCHOOL STUDENTS IN RURAL AND URBAN AREAS OF THAILAND: A CROSS-SECTIONAL STUDY

Results: A total of 526 students completed the questionnaires. Of these, 287 (54.6%) lived in rural areas. In all, 172 (32.7%) students had moderate to severe acne. No statistical significance was found between the proportion of moderate to severe acne and none to mild acne cases among students living in rural areas 94/287 (32.7%) and those living in urban area 78/239 (32.6%) (p =0.977). Being male and high BMI were associated with moderate to severe acne using the adjusted odds ratio (OR) =2.05 (95% CI, 1.38-3.05) and adjusted OR =1.06 (95% CI, 1.01-1.11). Milk consumption did not affect acne severity.

Quote from tim on October 21, 2021, 6:16 am

@daniil

There is plenty of acne in Thailand. Also, milk isn't high in vitamin A.

PREVALENCE AND ASSOCIATED FACTORS OF ACNE VULGARIS AMONG HIGH SCHOOL STUDENTS IN RURAL AND URBAN AREAS OF THAILAND: A CROSS-SECTIONAL STUDY

Results: A total of 526 students completed the questionnaires. Of these, 287 (54.6%) lived in rural areas. In all, 172 (32.7%) students had moderate to severe acne. No statistical significance was found between the proportion of moderate to severe acne and none to mild acne cases among students living in rural areas 94/287 (32.7%) and those living in urban area 78/239 (32.6%) (p =0.977). Being male and high BMI were associated with moderate to severe acne using the adjusted odds ratio (OR) =2.05 (95% CI, 1.38-3.05) and adjusted OR =1.06 (95% CI, 1.01-1.11). Milk consumption did not affect acne severity.

Firstly, they took the most vulnerable category of the population with acne. And among them there were only 32%, which is not much. I think in developed countries it would be more than 50%.

Secondly, the small sample size does not give the right to extrapolate to the whole of Thailand.

What are you trying to prove to me when I was there and saw everything?

There is a lot of vitamin A in milk in the form of retinol. I don't think that carothenoids cause acne, and their transformation in the body is insignificant.

"Milk consumption did not affect acne severity."

Does it affect the presence of acne?

add: When I see such studies, I get the impression that doctors are trying to prove that in countries with undeveloped medicine, the population is just as sick(or more sick). Which is certainly not the case, in undeveloped countries there is a healthier population

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puddleduck
Quote from Jiří on October 20, 2021, 8:02 pm

@orion I don't have much acne anymore, but clogged pores and small white heads on my nose. That's shit I have to deal with for decades now and it's not better at all after 3 years of low A diet.. 🙁

Kind of similar with me, seems the face is the last area to catch up with me, still very oily and dry at the same time, so basically clogged pores.  Standing near me my skin looks normal as anyone, but up close lots of cloggage!

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