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Choline and pregnancy
Quote from
Andrew B on November 7, 2022, 8:10 am
Fertility is a sign of good health and a very healthy child is a further sign of optimal health. Excess Vitamin A can lead to teratogenic risks and extra methylation factors can help lower the risks posed. Extra choline from eggs can have a number of benefits in pregnancy: pain reduction, anxiety reduction, long term benefits to the child's cognitive health, repairing damaged cells, reducing risk of neural tube defects, for breastmilk, placental health, easy and cheap source of protein, selenium and folate too.
Choline can help with absorption of nutrients in demand in pregnancy like magnesium and possibly potassium and zinc. Choline also helps modify fetal liver copper levels in a Wilson's disease model. Choline also helps with pre eclampsia. Choline is so necessary for a growing fetus that maternal choline can become depleted if there is not adequate supplementation. Choline has positive effects on reproductive health by increasing ovarian function and is vital for sperm health. Choline supplementation improves pregnancy outcomes. It's no coincidence that eggs high in choline improve pregnancy outcomes.
20 days at 150,000 IUs of Vitamin A (total 3 million) can also build up over many years quite easily say at 1,000 IUs excess daily x 10 years x 365 days = 3.65 million.
https://pubmed.ncbi.nlm.nih.gov/665178/
Fertility is a sign of good health and a very healthy child is a further sign of optimal health. Excess Vitamin A can lead to teratogenic risks and extra methylation factors can help lower the risks posed. Extra choline from eggs can have a number of benefits in pregnancy: pain reduction, anxiety reduction, long term benefits to the child's cognitive health, repairing damaged cells, reducing risk of neural tube defects, for breastmilk, placental health, easy and cheap source of protein, selenium and folate too.
Choline can help with absorption of nutrients in demand in pregnancy like magnesium and possibly potassium and zinc. Choline also helps modify fetal liver copper levels in a Wilson's disease model. Choline also helps with pre eclampsia. Choline is so necessary for a growing fetus that maternal choline can become depleted if there is not adequate supplementation. Choline has positive effects on reproductive health by increasing ovarian function and is vital for sperm health. Choline supplementation improves pregnancy outcomes. It's no coincidence that eggs high in choline improve pregnancy outcomes.
20 days at 150,000 IUs of Vitamin A (total 3 million) can also build up over many years quite easily say at 1,000 IUs excess daily x 10 years x 365 days = 3.65 million.
https://pubmed.ncbi.nlm.nih.gov/665178/
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Quote from
Andrew B on December 25, 2022, 6:28 am
Prenatal choline supplementation and early life iron deficiency. Our major finding was that choline supplementation normalized expression levels of more than half of all genes dysregulated by iron deficiency and multiple molecular networks, including those implicated in neurotransmission, autism, and schizophrenia. 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763487/?fbclid=IwAR2mCd2Lx8bEDoSDFm0Fpn4UcwG9vwqlJwpJSMiR7ELOTCBWCh1wdoMWaFE
Prenatal choline supplementation and early life iron deficiency. Our major finding was that choline supplementation normalized expression levels of more than half of all genes dysregulated by iron deficiency and multiple molecular networks, including those implicated in neurotransmission, autism, and schizophrenia. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763487/?fbclid=IwAR2mCd2Lx8bEDoSDFm0Fpn4UcwG9vwqlJwpJSMiR7ELOTCBWCh1wdoMWaFE
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Quote from
Andrew B on December 30, 2022, 2:08 pm
Choline, neurological development and brain function: A systematic review focusing on the first 1,000 days. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352907/
Choline, neurological development and brain function: A systematic review focusing on the first 1,000 days. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352907/
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Quote from
clare on January 19, 2023, 9:51 am
What I'm wondering is this: if choline is so very important in the diet, why are there healthy populations that eat very little and don't suffer birth defects and learning disabilities? People get more meat and eggs today in the western world than ever before but we have autism and alzheimers rates increasing. I ate maybe an egg a week growing up in our Sunday waffles and very little meat and I did quite well before years of carrot juicing and finally Accutane caught up with me. I love eggs but all my kids will always choose cereal/oats or a bread item if allowed. How can we need a nutrient so much that would be hard to get daily in significant amounts without backyard chickens and/or refrigeration? I live in a community of large families and plenty of chickens and even here I don't know anyone whose kids eat 2-3 eggs per day, that would be 30+/day just for the family. Do you think the modern fortification or chemicals make us need more?
What I'm wondering is this: if choline is so very important in the diet, why are there healthy populations that eat very little and don't suffer birth defects and learning disabilities? People get more meat and eggs today in the western world than ever before but we have autism and alzheimers rates increasing. I ate maybe an egg a week growing up in our Sunday waffles and very little meat and I did quite well before years of carrot juicing and finally Accutane caught up with me. I love eggs but all my kids will always choose cereal/oats or a bread item if allowed. How can we need a nutrient so much that would be hard to get daily in significant amounts without backyard chickens and/or refrigeration? I live in a community of large families and plenty of chickens and even here I don't know anyone whose kids eat 2-3 eggs per day, that would be 30+/day just for the family. Do you think the modern fortification or chemicals make us need more?
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Quote from
Andrew B on January 19, 2023, 12:22 pm
@clare There's choline in virtually everything: oats, wheat, eggs, nuts, seeds, fish, meat, eggs. Combinations of foods are very beneficial for choline and betaine. Some traditional foods like goose fat, beef tallow, offal and steak and kidney pie are very high in choline. Some countries do eat an egg a day. Grains for betaine take some of the burden away from choline converting to betaine. Eating high carotenoids all year round may be part of the problem in using up more choline. Eating liver too often may be part of it too. Various things in modern life compromise the build up. Oral contraceptives. Certain medicinal drugs. Electric lights at night may be part of the problem as well. The need for more eggs a day may be partly only required to help detox or replenish stores. Gluten/glyphosate intolerance may reduce choline considerably. Excessive consumption of alcohol uses choline up in all likelihood.
@clare There's choline in virtually everything: oats, wheat, eggs, nuts, seeds, fish, meat, eggs. Combinations of foods are very beneficial for choline and betaine. Some traditional foods like goose fat, beef tallow, offal and steak and kidney pie are very high in choline. Some countries do eat an egg a day. Grains for betaine take some of the burden away from choline converting to betaine. Eating high carotenoids all year round may be part of the problem in using up more choline. Eating liver too often may be part of it too. Various things in modern life compromise the build up. Oral contraceptives. Certain medicinal drugs. Electric lights at night may be part of the problem as well. The need for more eggs a day may be partly only required to help detox or replenish stores. Gluten/glyphosate intolerance may reduce choline considerably. Excessive consumption of alcohol uses choline up in all likelihood.
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Quote from
Jenny on January 19, 2023, 4:32 pm
Interesting fact from Steven Zeisel work, populations who historically eat lowish choline diets have very low levels of PEMT SNPs. This means that all the young women make plenty of choline due to working PEMT gene so will not be dependant on the diet and can have healthy babies despite a low choline diet. PEMT SNPs stop women making choline under influence of oestrogen and can only survive in populations who eat a higher choline diet. This information really shows how important choline is for pregnancy. What happens when a population that’s genetically adapted to a high choline diet starts eating a low choline diet, like a vegan diet? Can’t be pretty I imagine.
Interesting fact from Steven Zeisel work, populations who historically eat lowish choline diets have very low levels of PEMT SNPs. This means that all the young women make plenty of choline due to working PEMT gene so will not be dependant on the diet and can have healthy babies despite a low choline diet. PEMT SNPs stop women making choline under influence of oestrogen and can only survive in populations who eat a higher choline diet. This information really shows how important choline is for pregnancy. What happens when a population that’s genetically adapted to a high choline diet starts eating a low choline diet, like a vegan diet? Can’t be pretty I imagine.
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puddleduckRachelclareAndrew B
Quote from
Rachel on January 20, 2023, 4:55 am
As someone who has pretty compromised PEMT status and who went vegan for 10+ years I can confirm it isn't pretty 🙂 Of course I can't currently confirm that lack of choline is the problem for me but I have just started eating eggs and am crossing my fingers that insufficient of choline is the piece of the puzzle I have been missing.
I have had this sense for the last few years that I was missing something important that was hampering my recovery and I so hope this is it.
As someone who has pretty compromised PEMT status and who went vegan for 10+ years I can confirm it isn't pretty 🙂 Of course I can't currently confirm that lack of choline is the problem for me but I have just started eating eggs and am crossing my fingers that insufficient of choline is the piece of the puzzle I have been missing.
I have had this sense for the last few years that I was missing something important that was hampering my recovery and I so hope this is it.
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Quote from
Sarabeth on January 20, 2023, 6:14 am
That study is fascinating. Thank you for posting.
That study is fascinating. Thank you for posting.
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