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Choline and pregnancy
Quote from
Jenny on January 20, 2023, 1:34 pm
@rachel oh no vegan and PEMT SNPs are not friends! Your experience is very interesting though. I’ve felt exactly the same - that something crucial is missing. Choline ticks a lot of boxes for being a big missing piece. It then can create more deficiencies by messing up cell membranes. There is a great chapter on PEMT SNPs in Ben Lynch Dirty Genes book, I may have said already. Lack of choline can really mess up the body 😞
@rachel oh no vegan and PEMT SNPs are not friends! Your experience is very interesting though. I’ve felt exactly the same - that something crucial is missing. Choline ticks a lot of boxes for being a big missing piece. It then can create more deficiencies by messing up cell membranes. There is a great chapter on PEMT SNPs in Ben Lynch Dirty Genes book, I may have said already. Lack of choline can really mess up the body 😞
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Quote from
Andrew B on May 20, 2023, 3:13 am
9. Conclusions and Future Directions
Data from both animal and human studies highlight the importance of ensuring an adequate choline intake during pregnancy. Supplementing the maternal diet with additional choline has been shown to improve offspring cognition, neurodevelopment, and placental functioning, and to protect against neural and metabolic insults. However, RCTs on prenatal choline and pregnancy outcomes are limited and the dose–response relationship between maternal choline intake and offspring health remains to be fully discerned. Future clinical interventions with larger sample sizes, multiple dosages, specific endpoints with clinical utility, mechanistic measurements, and long-term follow-up are needed to establish maternal choline intake recommendations that optimize fetal development and reduce the risk of pregnancy complications. In the interim, consumption of 450–1000 mg choline/day appears to be an intake level that would support fetal development and improve pregnancy outcomes based on the available and emerging science.
Nutrients | Free Full-Text | Choline: Exploring the Growing Science on Its Benefits for Moms and Babies (mdpi.com)
9. Conclusions and Future Directions
Data from both animal and human studies highlight the importance of ensuring an adequate choline intake during pregnancy. Supplementing the maternal diet with additional choline has been shown to improve offspring cognition, neurodevelopment, and placental functioning, and to protect against neural and metabolic insults. However, RCTs on prenatal choline and pregnancy outcomes are limited and the dose–response relationship between maternal choline intake and offspring health remains to be fully discerned. Future clinical interventions with larger sample sizes, multiple dosages, specific endpoints with clinical utility, mechanistic measurements, and long-term follow-up are needed to establish maternal choline intake recommendations that optimize fetal development and reduce the risk of pregnancy complications. In the interim, consumption of 450–1000 mg choline/day appears to be an intake level that would support fetal development and improve pregnancy outcomes based on the available and emerging science.
Nutrients | Free Full-Text | Choline: Exploring the Growing Science on Its Benefits for Moms and Babies (mdpi.com)
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