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CONSIDERED A HAZARDOUS SUBSTANCE ACCORDING TO OSHA 29 CFR 1910.1200.
Quote from ggenereux on July 16, 2021, 10:38 amHere's a MSDS for retinoic acid.
https://datasheets.scbt.com/sc-205568.pdf
Here's a MSDS for retinoic acid.
Quote from lil chick on July 16, 2021, 2:06 pmfor those who can't see the small writing, "Retinoids such as etretinate and isotretinoin, taken in therapeutic doses, may produce dryness of the mucous membranes, sometimes witherosion, involving the lips (cheilitis), mouth, conjunctiva (sometimes causing conjunctivitis), and nasal mucosa and epistaxis (rarely causingepistaxis). Other symptoms may include flare-up of acne, peeling of the palms, soles and fingertips, rhinorrhoea, nosebleed, gingivalbleeding, nail fragility, easy sunburning, fever and mild headache. Ocular defects may include problems with night vision, and alterations incolour perception. Musculoskeletal effects include aching joints and backache. Neurological symptoms include fatigue, minor depression, andinsomnia. Decreased libido and menstrual irregularities have been reported in etretinate therapies. Liver and kidney dysfunction has beensuggested after abnormal laboratory tests and following the appearance of calcified tendons and ligaments in the ankles, pelvis, and knees;hepatitis has been reported in a significant number of patients (1.5%). Dryness of the skin may result in scaling, thinning, pruritus, exfoliation,and erythema. Thinning of the hair or alopecia may occur by the fourth week of etretinate treatment. Skeletal hyperostosis, benignintracranial hypertension, musculoskeletal pain, gastrointestinal effects and paronychia have also occurred. Serum levels of hepatic enzymesand triglyceride concentrations may be elevated.Isotretinoin therapy has produced corneal opacities and premature epiphyseal closure. Such therapy has also been associated with skininfection and an inflammatory bowel syndrome."
@ourania, look "changes in color perception"!
Oh look all the other symptoms that we all complain about here too!
for those who can't see the small writing, "Retinoids such as etretinate and isotretinoin, taken in therapeutic doses, may produce dryness of the mucous membranes, sometimes witherosion, involving the lips (cheilitis), mouth, conjunctiva (sometimes causing conjunctivitis), and nasal mucosa and epistaxis (rarely causingepistaxis). Other symptoms may include flare-up of acne, peeling of the palms, soles and fingertips, rhinorrhoea, nosebleed, gingivalbleeding, nail fragility, easy sunburning, fever and mild headache. Ocular defects may include problems with night vision, and alterations incolour perception. Musculoskeletal effects include aching joints and backache. Neurological symptoms include fatigue, minor depression, andinsomnia. Decreased libido and menstrual irregularities have been reported in etretinate therapies. Liver and kidney dysfunction has beensuggested after abnormal laboratory tests and following the appearance of calcified tendons and ligaments in the ankles, pelvis, and knees;hepatitis has been reported in a significant number of patients (1.5%). Dryness of the skin may result in scaling, thinning, pruritus, exfoliation,and erythema. Thinning of the hair or alopecia may occur by the fourth week of etretinate treatment. Skeletal hyperostosis, benignintracranial hypertension, musculoskeletal pain, gastrointestinal effects and paronychia have also occurred. Serum levels of hepatic enzymesand triglyceride concentrations may be elevated.Isotretinoin therapy has produced corneal opacities and premature epiphyseal closure. Such therapy has also been associated with skininfection and an inflammatory bowel syndrome."
@ourania, look "changes in color perception"!
Oh look all the other symptoms that we all complain about here too!
Quote from lil chick on July 16, 2021, 2:21 pmWow... just wow
"Exposure to the material for prolonged periods may cause physical defects in the developing embryo (teratogenesis).Prolonged overdose of Vitamin A is associated with fatigue, irritability, loss of weight and appetite, mild fever, increased amounts of urine,enlarged liver and spleen, hair loss, bleeding lips, thickening of skin and yellow pigmentation. Bone and joint pain may occur, and growth maybe permanently arrested in children."
Wow... just wow
"Exposure to the material for prolonged periods may cause physical defects in the developing embryo (teratogenesis).Prolonged overdose of Vitamin A is associated with fatigue, irritability, loss of weight and appetite, mild fever, increased amounts of urine,enlarged liver and spleen, hair loss, bleeding lips, thickening of skin and yellow pigmentation. Bone and joint pain may occur, and growth maybe permanently arrested in children."
Quote from lil chick on July 16, 2021, 2:25 pm"Vitamin A is usually well absorbed from the gastro-intestinal tract Large doses are absorbed less effectively. Emulsification by bile salts and phospholipids facilitate absorption. Conjugation by glucuronic acid occurs in liver and metabolism proceeds in both liver and kidney leaving30-50% of the dose for liver storage. It is bound to a globulin (retinol-binding protein) in the blood; metabolites are excreted in the urine and faeces.
I had to look this one up,
Phospholipids are found in foods like meat, eggs, seed oils, and seafood. They're also found in some plant foods but in much smaller amounts. Phospholipids can also be found in supplements. Marine phospholipids are derived from fish, algae, and shellfish like krill.
"Vitamin A is usually well absorbed from the gastro-intestinal tract Large doses are absorbed less effectively. Emulsification by bile salts and phospholipids facilitate absorption. Conjugation by glucuronic acid occurs in liver and metabolism proceeds in both liver and kidney leaving30-50% of the dose for liver storage. It is bound to a globulin (retinol-binding protein) in the blood; metabolites are excreted in the urine and faeces.
I had to look this one up,
Phospholipids are found in foods like meat, eggs, seed oils, and seafood. They're also found in some plant foods but in much smaller amounts. Phospholipids can also be found in supplements. Marine phospholipids are derived from fish, algae, and shellfish like krill.
Quote from lil chick on July 16, 2021, 2:36 pmI never thought about the fact that the powdered contents of a vitamin A containing pill, if inhaled, could harm your lungs !
I remember people (especially those that hated cod liver oil) choking on it and sometimes it going down the wrong pipe! It might have even happened to me once.
I never thought about the fact that the powdered contents of a vitamin A containing pill, if inhaled, could harm your lungs !
I remember people (especially those that hated cod liver oil) choking on it and sometimes it going down the wrong pipe! It might have even happened to me once.
Quote from Max on July 17, 2021, 5:09 amWhoever had the idea to poison young men and women with accutane, should be put into jail.
Whoever had the idea to poison young men and women with accutane, should be put into jail.