Quote from puddleduck on February 15, 2019, 10:05 am

@yh Oh how interesting! Thanks for including some dietary sources of anthocyanin. 🙂 This week I’ve been craving raisins, strawberries, rasberries, and apples, but have only eaten them in small quantities. Fun fact I just learned: apples grown in cool climates have higher anthocyanin levels than those grown in warm climates (even golden delicious will blush red in the north).

Quote from YH on February 15, 2019, 3:41 pm

@puddleduck I’ve  been craving these foods as well. Even dreamed about eating blackberry preserves.  Ive been avoiding apple peels for the most part. That’s good to know about the color!

 

Quote from Liz on February 15, 2019, 10:18 pm

Quote from YH on February 13, 2019, 1:43 pm

Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice.

 

Abstract

Adipocyte dysfunction is strongly associated with the development of obesity and insulin resistance. It is accepted that the regulation of adipocytokine expression is one of the most important targets for the prevention of obesity and improvement of insulin sensitivity. In this study, we have demonstrated that anthocyanin (cyanidin 3-glucoside; C3G) which is a pigment widespread in the plant kingdom, ameliorates hyperglycemia and insulin sensitivity due to the reduction of retinol binding protein 4 (RBP4) expression in type 2 diabetic mice. KK-A(y) mice were fed control or control +0.2% of a C3G diet for 5 weeks. Dietary C3G significantly reduced blood glucose concentration and enhanced insulin sensitivity. The adiponectin and its receptors expression were not responsible for this amelioration. C3G significantly upregulated the glucose transporter 4 (Glut4) and downregulated RBP4 in the white adipose tissue, which is accompanied by downregulation of the inflammatory adipocytokines (monocyte chemoattractant protein-1 and tumor necrosis factor-alpha) in the white adipose tissue of the C3G group. These findings indicate that C3G has significant potency in an anti-diabetic effect through the regulation of Glut4-RBP4 system and the related inflammatory adipocytokines.

The pigment is found in fruits likes berries, grapes, apples, plums, and veggies like red cabbage and red onion.

 

Can someone dumb this down for me? I dont think I get it. I read it as RBP is being downregulated, which would mean less RPB being produced, which would mean less transport vessles for retinol.

Or as it was downregulated in the fat (white adipose tissue) do they mean A cannot leave the fat due to less vessles, or that less RBP is arriving to the fat, as in less A being stored?

Honestly, the whole RBP topic is highly confusing. We "need" it to transport retinol, butter increases it and that is why dr G believe butter is okay despite being high A. But what I dont get, is how can one know if RBP is being contraproductive or not, as in transporting retinol into/back into storage, or transporting it to be discarded/eliminated?

Someome please help my poor A fried brains understand 🤔