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depression, mental illness, psychosis, irritability, suicidal thoughts
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276716/
A number of cases have been reported in the literature of mental symptoms associated with vitamin A toxicity, including irritability, depression, lethargy, mood lability, and psychosis.31-39 These symptoms resolve with discontinuation of vitamin A.36, 38, 40-42 For instance, Restak40 reported a case of vitamin A toxicity associated with the development of aggression, personality changes, and depression, which resolved with discontinuation. McCance-Katz and Price43 reported a case of chronic vitamin A intoxication which was associated with a one-year history of depressed mood, poor concentration, tearfulness, and guilty rumination. The patient had no prior history or family history of depression. He also had fatigue and fears of cancer with a Hamilton Depression Scale (HAM-D, a quantitative measure of depression) score of 29, indicating severe depression. Four weeks after discontinuation of vitamin A the HAM-D Score dropped to 6, and the patient was completely normal two months after treatment.
.......She developed insomnia, loss of weight and appetite. She became “completely disinterested in her surroundings and was found to brood all the time.” One week after discontinuation of vitamin A her symptoms resolved.
.....Haupt 45 also reported a case of psychosis with vitamin A intoxication. Frame et al31 described a 16 year old boy with emotional lability and loss of appetite associated with taking high doses of vitamin A. After discontinuation of the supplement the symptoms resolved
.....these cases were associated with neurological effects of drowsiness and inability to grasp objects in one patient, and in the second patient psychotic symptoms of insects crawling over the body with the bizarre behavior of trying to cut off his son’s hair because he thought insects had infested his son’s body. There was no prior history of psychiatric disorder and the symptoms resolved with the discontinuation of vitamin A
.... A study of members of the Israeli armed services looked at 1419 conscripts who had used isotretinoin83 and found a statistically significant increase in suicidal thoughts and suicide attempts as well as a significant increase in mental health services utilization in those individuals compared to controls.
The depressed woman sounds a lot like my case although it never went farther than mild depressuon for me.
Children are starting to have a lot of mental issues (ADD, depression, anxiety). There are even TV ads bringing light on the subject. It's crazy how much damage 1 nutrient is able to do.
I’ve struggled with anxiety and depression off and on basically my whole adult life. This is the first winter I can remember not having SAD. It’s pretty strange that 3 weeks after I started the A depletion my mom passed away and although I have naturally grieved I haven’t struggled with my normal dysthymia and have basically steadily improved on the mental health front. I still miss my mom of course but this is the first time in my life since childhood that I can remember feeling positive, hopeful, reasonably energetic and capable of handling things on a consistent basis. I’m starting to think it has been completely related to vitamin A in my case all along. It’s pretty strange but I’m happy for it.