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Do stopping bile acid reabsorbtion really dumps vitamin A?
IF ANYONE HAVE SOME INFORMATION ABOUT "STOPPING BILE ACID REABSORBED DUMPS VITAMIN A "PLZ WRITE IT DOWN!
See my post in chickadees thread about GI issues.
I've made a number of posts about this. The short answer...no, because Vitamin A does not get ejected by the liver connected to bile acid. Bile acids come out of the liver connected to taurine or glycine, are used to absorb dietary fat, and then approximately 95% of them get reabsorbed in the small intestine. Approximately 5% pass into the colon where bacteria convert them to secondary bile acids.
Vitamin A that is ejected by the liver into the intestines is supposed to be bound to a glucuronide, which is supposed to make it more water soluble and more likely to pass into the colon without being reabsorbed in the small intestine. I think some Vitamin A can also be bound directly to taurine and passed into the small intestine for elimination. The primary way this Vitamin A can get reabsorbed before reaching the stool is if bacteria break the bond with taurine or the glucuronide (via an enzyme called beta-glucuronidase). This is probably most likely to happen if you bacterial overgrowth in the small intestine, or possibly also at the very beginning of the large intestine, and/or if your bowels are moving slowly (note: soluble fiber slows bowel motility and increases the number of some bacteria in the bowels that feed on the fiber).
Quote from wavygravygadzooks on July 29, 2022, 12:00 pmI've made a number of posts about this. The short answer...no, because Vitamin A does not get ejected by the liver connected to bile acid. Bile acids come out of the liver connected to taurine or glycine, are used to absorb dietary fat, and then approximately 95% of them get reabsorbed in the small intestine. Approximately 5% pass into the colon where bacteria convert them to secondary bile acids.
Vitamin A that is ejected by the liver into the intestines is supposed to be bound to a glucuronide, which is supposed to make it more water soluble and more likely to pass into the colon without being reabsorbed in the small intestine. I think some Vitamin A can also be bound directly to taurine and passed into the small intestine for elimination. The primary way this Vitamin A can get reabsorbed before reaching the stool is if bacteria break the bond with taurine or the glucuronide (via an enzyme called beta-glucuronidase). This is probably most likely to happen if you bacterial overgrowth in the small intestine, or possibly also at the very beginning of the large intestine, and/or if your bowels are moving slowly (note: soluble fiber slows bowel motility and increases the number of some bacteria in the bowels that feed on the fiber).
I have a question about this ..so why Dr Smith recommend activated charcoal & soluble fiber for detox ..?
Uh, because Smith apparently doesn't understand basic physiology? Because he doesn't understand or believe in evolution? Because he thinks bile acid is the devil incarnate? Who knows, but he's blatantly wrong about all kinds of stuff and I wouldn't believe a single thing he says without looking elsewhere to see what other people have to say on the subject. He has chosen to believe that Vitamin A and cholestasis are the cause of all known disease and he twists anything he finds to fit that ridiculous unsubstantiated worldview of his.
That being said, feel free to experiment with charcoal and soluble fiber and see what happens. I've tried them personally and I don't think they're necessary, nor do I think they were beneficial. Fiber definitely does something that appears to increase Vitamin A dumping, but I don't think you need it if you're eating animal fat, and it has drawbacks like blocking nutrient absorption and wasting cholesterol and taurine.
Quote from wavygravygadzooks on July 29, 2022, 9:25 pmUh, because Smith apparently doesn't understand basic physiology? Because he doesn't understand or believe in evolution? Because he thinks bile acid is the devil incarnate? Who knows, but he's blatantly wrong about all kinds of stuff and I wouldn't believe a single thing he says without looking elsewhere to see what other people have to say on the subject. He has chosen to believe that Vitamin A and cholestasis are the cause of all known disease and he twists anything he finds to fit that ridiculous unsubstantiated worldview of his.
That being said, feel free to experiment with charcoal and soluble fiber and see what happens. I've tried them personally and I don't think they're necessary, nor do I think they were beneficial. Fiber definitely does something that appears to increase Vitamin A dumping, but I don't think you need it if you're eating animal fat, and it has drawbacks like blocking nutrient absorption and wasting cholesterol and taurine.
Thank you so much for the information ❤️ ..what about your vagus nerve distinction are you going good with your acid reflux?
"Vitamin A that is ejected by the liver into the intestines is supposed to be bound to a glucuronide, which is supposed to make it more water soluble and more likely to pass into the colon without being reabsorbed in the small intestine"
So Vitamin A is made water soluble? So we just pee it out?
From the information I've read, the primary route of elimination for Vitamin A is in the stool, but I think it does also get eliminated in the urine.
I never had acid reflux. My symptoms that I think are related to vagus nerve problems still come and go, and they seem to be brought on primarily by high fat intake (or potentially by high fiber intake, but I haven't been eating fiber regularly outside of my isolated experiments with it). I think pretty much anything that speeds up some part of the detox process increases these and other symptoms, so taking thiamine and other B vitamins also seems to cause nervous system problems for me.
It is a good idea to read this thread : https://ggenereux.blog/discussion/topic/this-book-will-change-your-life-100-overnight/
A lot of retinol is excreted through the breath. Somewhere on this forum there is a post explaining that the breath accounts for 40% of retinol detoxification, but I can"t find it!
Quote from wavygravygadzooks on July 29, 2022, 12:00 pmVitamin A that is ejected by the liver into the intestines is supposed to be bound to a glucuronide, which is supposed to make it more water soluble and more likely to pass into the colon without being reabsorbed in the small intestine. I think some Vitamin A can also be bound directly to taurine and passed into the small intestine for elimination. The primary way this Vitamin A can get reabsorbed before reaching the stool is if bacteria break the bond with taurine or the glucuronide (via an enzyme called beta-glucuronidase). This is probably most likely to happen if you bacterial overgrowth in the small intestine, or possibly also at the very beginning of the large intestine, and/or if your bowels are moving slowly (note: soluble fiber slows bowel motility and increases the number of some bacteria in the bowels that feed on the fiber).
We really need to establish which forms of vitamin A and what percentages are excreted in the bile to move closer to understanding the best ways of assisting its excretion.
I don't want to get into a debate about fiber but for those that are getting pectin and beta glucan in their diet I can't see how soluble fiber won't bind water soluble forms.