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Do stopping bile acid reabsorbtion really dumps vitamin A?
I found something interesting!
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2.3.6.2. Faecal, breath and urinary losses
The majority of retinol metabolites are excreted in the urine, but they are also excreted in faeces and
breath. The percentage of a radioactive dose of 14C‐labelled retinyl acetate recovered in breath, faeces
and urine ranged from 18 to 30 %, from 18 to 37 % and from 38 to 60 %, respectively, after 400 days
on a vitamin A-deficient diet (Sauberlich et al., 1974). Retinol is metabolised in the liver to numerous
products, some of which are conjugated with glucuronic acid or taurine for excretion in bile (Zile et
al., 1982; Skare and DeLuca, 1983), and the amount of retinol metabolites excreted in bile increases as
the liver retinol exceeds a critical concentration. Excretion of labelled retinol metabolites in bile of rats
fed increasing amounts of retinol traced by [3H]-retinyl acetate was constant when hepatic retinol
concentrations were low (≤ 32 µg/g (112 nmol/g) and increased rapidly (by eight-fold) as liver retinol
concentration increased, up to a plateau at hepatic retinol concentration ≥ 140 µg/g (490 nmol/g)
(Hicks et al., 1984). This increased biliary excretion may serve as a protective mechanism for reducing
the risk of excess storage of vitamin A.
https://efsa.onlinelibrary.wiley.com/doi/pdf/10.2903/j.efsa.2015.4028
I wonder how much of a difference fresh air makes for depleting vitamin A? If one is indoors with others breathing each other's breath and one's own breath some vitamin A will probably be absorbed..
through Bile & urine vitamin a get detox
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Quote from Ourania on July 30, 2022, 11:24 pmIt is a good idea to read this thread : https://ggenereux.blog/discussion/topic/this-book-will-change-your-life-100-overnight/
A lot of retinol is excreted through the breath. Somewhere on this forum there is a post explaining that the breath accounts for 40% of retinol detoxification, but I can"t find it!
Is this related to carbon dioxide?
This is a very interesting question @michael2. I always thought that it was linked to the excretion of lymph particules in the outgoing breath, due to the pressure on the lungs during expiration. A lot of lymph is excreted this way, which accounts for the pulmonary problems developed when the lymph is too caustic.
During detox moments the lungs hurt and I try to breathe less deeply to avoid this, hence the shortness of breath experienced in detox episodes. I suppose that if it got too bad, you would get more intense irritation in the lungs, then micro wounds leading the way to bacterial infection and pneumonia.
But the carbon dioxide angle is interesting too. When there is enough carbon dioxide relatively speaking in the blood, you get the Bohr effect and a dilatation of vessels, blood vessels but also lymph vessels, that would allow for more excretion on each exhale.