I needed to disable self sign-ups because I’ve been getting too many spam-type accounts. Thanks.
Please
Login to create posts and topics.
Fatty Liver
Quote from
Anon33 on November 26, 2023, 7:14 am
I was reading this blog post (https://ggenereux.blog/2020/02/19/100-million-americans-now-have-nafld/) making the argument that fatty liver is yellow due to excessive vitamin A storage where Grant says "What am I missing here? Has no one ever before bothered to ask the obvious question: why has that NAFLDed liver turned YELLOW?". I then googled "why does fatty liver turn yellow" and found it's due to a poorly functioning liver that is unable get rid of bilirubin. Bilirubin is just a red-orange compound that occurs in the normal breakdown of heme in vertebrates.
Was this just an oversight or is there evidence that bilirubin is not the actual cause of a yellow fatty liver?
I was reading this blog post (https://ggenereux.blog/2020/02/19/100-million-americans-now-have-nafld/) making the argument that fatty liver is yellow due to excessive vitamin A storage where Grant says "What am I missing here? Has no one ever before bothered to ask the obvious question: why has that NAFLDed liver turned YELLOW?". I then googled "why does fatty liver turn yellow" and found it's due to a poorly functioning liver that is unable get rid of bilirubin. Bilirubin is just a red-orange compound that occurs in the normal breakdown of heme in vertebrates.
Was this just an oversight or is there evidence that bilirubin is not the actual cause of a yellow fatty liver?
Quote from
ggenereux on November 26, 2023, 7:49 am
Hi @anon33,
Google: Percentage of vitamin A stored in stellate cels?
HSCs (hepatic stellate cells) (also called vitamin A-storing cells, lipocytes, interstitial cells, fat-storing cells or Ito cells) exist in the space between parenchymal cells and liver sinusoidal endothelial cells of the hepatic lobule and store 50-80% of vitamin A in the whole body as retinyl palmitate in lipid ...
Vitamin A and beta carotene are yellow.
It's the same reason people have their skin turn yellow from eating too much beta carotene.
Hi @anon33,
Google: Percentage of vitamin A stored in stellate cels?
HSCs (hepatic stellate cells) (also called vitamin A-storing cells, lipocytes, interstitial cells, fat-storing cells or Ito cells) exist in the space between parenchymal cells and liver sinusoidal endothelial cells of the hepatic lobule and store 50-80% of vitamin A in the whole body as retinyl palmitate in lipid ...
Vitamin A and beta carotene are yellow.
It's the same reason people have their skin turn yellow from eating too much beta carotene.
Anon33, Javier and Joe2 have reacted to this post.
Quote from
Pawel on November 26, 2023, 3:00 pm
Quote from
ggenereux on November 26, 2023, 7:49 am
Hi @anon33,
Google: Percentage of vitamin A stored in stellate cels?
HSCs (hepatic stellate cells) (also called vitamin A-storing cells, lipocytes, interstitial cells, fat-storing cells or Ito cells) exist in the space between parenchymal cells and liver sinusoidal endothelial cells of the hepatic lobule and store 50-80% of vitamin A in the whole body as retinyl palmitate in lipid ...
Vitamin A and beta carotene are yellow.
It's the same reason people have their skin turn yellow from eating too much beta carotene.
Am I missing here something or this information* does not contradict the thesis that the liver turns yellow because of the bilirubin, not vA?
*- information that 50-80% of vA in the body is located in the liver.
I mean: liver can still hold 50-80% of vA in the body, but turn yellow only because of wrong bilirubin metabolism. This pair is not possible?
Quote from
ggenereux on November 26, 2023, 7:49 am
Hi @anon33,
Google: Percentage of vitamin A stored in stellate cels?
HSCs (hepatic stellate cells) (also called vitamin A-storing cells, lipocytes, interstitial cells, fat-storing cells or Ito cells) exist in the space between parenchymal cells and liver sinusoidal endothelial cells of the hepatic lobule and store 50-80% of vitamin A in the whole body as retinyl palmitate in lipid ...
Vitamin A and beta carotene are yellow.
It's the same reason people have their skin turn yellow from eating too much beta carotene.
Am I missing here something or this information* does not contradict the thesis that the liver turns yellow because of the bilirubin, not vA?
*- information that 50-80% of vA in the body is located in the liver.
I mean: liver can still hold 50-80% of vA in the body, but turn yellow only because of wrong bilirubin metabolism. This pair is not possible?
