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HUFA deficiency/imbalance?
Study:
https://pubmed.ncbi.nlm.nih.gov/19351970/
Write up:
https://www.sciencedaily.com/releases/2010/04/100412121022.htm
The PUFA ratios are all out of whack in the modern world and much like the mice we have an abundance of LA, but are we able to convert it to AA?
Diet from this study contains vitamin A. I can't find the diet for the group they mention that ran a similar experiment that didn't have adverse skin problems:
Uploaded files:
I’ve been sorting through my nutritional therapy notes this week and had read this list of things that slow down the enzyme mentioned in the study. I thought it might be relevant here. It’s easy to see why this enzyme is vulnerable in modern day life, meaning that omega 6 & 3 fatty acids can get out of balance.
Factors that negatively affect delta-6-saturase: stress, genetics, NSAIDS, steroids, viral infections, Candida, alcohol, tobacco, getting old.
Makes me wonder if vitamin A toxicity has an effect on this enzyme.
PUFA imbalance and atopic disease:
https://tandfonline.com/doi/pdf/10.3109/07853899908995891?needAccess=true…
Bit of PUFA epidemiology:
https://www.jacionline.org/article/S0091-6749(99)70513-0/fulltext
Omega 3 / Omega 6 imbalance is a red herring, both are toxic and non-essential.