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Mice that Get Lupus
Look! There are genetic lines of mice (inbred) who spontaneously get Lupus! (Or, as I like to call it: "High-VA Disease" lol)
https://link.springer.com/article/10.1007/s11926-002-0046-5
"An update on genetic studies of systemic lupus erythematosus...
In well-defined experimental transgenic or gene-knockout mouse models, the development of lupus-like disease has implicated specific genes and pathways in the disease pathogenesis. Linkage analyses have mapped multiple susceptibility loci and disease suppressive loci using inbred strains of mice that spontaneously develop lupus-like disease. Elegant genetic dissection and function studies have led to the recent identification of two murine candidate susceptibility genes, Ifi202 (encoding an interferon-inducible protein) and Cr2 (encoding complement receptors 1 and 2). In human lupus, casecontrol studies have established associations of SLE with certain major histocompatibility class II alleles, complement deficiencies, and polymorphisms of Fcψ receptor genes, a complement-related gene, and cytokine genes. During the past several years, linkage analyses using SLE multiplex families have provided many chromosomal regions for further exploration of susceptibility genes. Six regions exhibiting significant linkage to SLE are promising. Studies are underway to fine map these linked regions and to identify the genes in the susceptibility regions. An understanding of the genes involved in the development of lupus should provide targets for more focused therapy in lupus."
Me talking again: Could the inability to deal with VA be a recessive thing which is made worse when a person's family TREE is more like a WREATH (small attempt at a joke in case the subject seems a little taboo haha)?
There were only so many people on the Earth if you go back a few hundred years, and we are are all pulling from that smallish population in reality. Sometimes a group of people become alienated (by choice or geography) and we modern people often have no idea that things like that went on.
I was talking to another low VA'er offline and realized we both come from populations in which everyone was related to everyone.
I've said many times: "I'm a walking recessive gene" LOL.
Could the genes that handle VA regulation start to lean away from balance when many of your ancestors are genetically related?
Here is a side-thought that came to me...I don't want to defer thought away from the original post which I think is important..
I remember reading this long ago: That women on the pill are more attracted to people who are genetically related...than women who are not on the pill. I'm not going to hunt it down, it could be true or not true. But if true, it could be a reason that VA intolerance might be increasing.
Now these are the mice we need for our backyard experiments. You could test out all the various theories on them! High A, Low A, Medium A, gluten, apples, alcohol etc etc etc.
"It's NEVER lupus," said Dr. House.
Lupus isn't a new disease. From the google machine:
"The word 'lupus' (Latin for 'wolf') is attributed to the thirteenth century physician Rogerius who used it to describe erosive facial lesions that were reminiscent of a wolf's bite."
"Lupus occurs when your immune system attacks healthy tissue in your body (autoimmune disease). ... It appears that people with an inherited predisposition for lupus may develop the disease when they come into contact with something in the environment that can trigger lupus."
"Lupus is sometimes called "the great imitator" because its symptoms are often like the symptoms of rheumatoid arthritis, blood disorders, fibromyalgia, diabetes, thyroid problems, Lyme disease, and a number of heart, lung, muscle, and bone diseases."
discoid lupus stock photo