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Mechanism of retinoic acid's effect of gene expression
Hi all! This is my first post, apologies if this is covered elsewhere (I couldn't seem to find it).
Grant writes in Poisoning for Profits that toxicity occurs because the cyclohexane group of retinoic acid / retinol can incorporate into RNA, which negatively impacts protein production.
I’ve tried finding references to support this, but can only find research describing how retinoic acid binds retinoic acid receptors (RARs) and retinoid X receptors (RXRs) which then go on to “regulate gene expression”. The latter sounds like a controlled, intentional process whereas what Grant describes sounds like uncontrolled mayhem (and I think that’s his point).
Has anyone seen references to support Grant’s view on the mechanism here? I’m very new to the topic and only 48 pages into the PDF, so not sure if it’s explained in further detail later.
Thank you in advance!
I’m not sure if this is the right place to post it but I came across this Moderna mrna article about testing re Crigler-Najjar syndrome (liver related).
https://www.statnews.com/2017/01/10/moderna-trouble-mrna/?trk=comments_comments-list_comment-text
Does anyone know if there is any link with vitamin a? Could this be another reason why so many people are having liver, colon, gallbladder etc issues after the vaccine?