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Metabolic Interactions between Vitamin A and Conjugated Linoleic Acid

I found this article while looking up Palmitoyelthanolamide (PEA), a substance I take occasionally for itching and pain at night. Interesting information about the relationship between retinol and CLA as well.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967192/

 

Increases retinol levels in tissues? That sounds bad.

Yes, this may explain why I was having an increase in symptoms (hives, acne, insomnia) back when I was eating a diet of predominantly high fat beef.

CLA is more abundant in grass fed meat. Should we switch to corn fed?

@ronnie, I have no idea. I'm just posting the study. What I'm personally taking from this is that I am not going too heavy on meat - only eat 6-8 oz a day, in addition to bread, rice, potatoes, low vitamin a snacks, etc. I used to eat mostly meat, and had terrible reactions.

Appears that there are quite a few benefits to Palmitoylethanolamide (PEA), wondering if this could be helpful during the detox ?

https://antiaging-health.com.au/palmitoylethanolamide_pea_100_pure

From the link above:

More than 500 clinical studies show that Palmitoylethanolamide (PEA) is effective in reducing chronic pain, neuropathic pain and chronic inflammation.

I wonder if any of these studies were indirectly looking at retinol and inflammation...

Will look into this more...

@jobo - I'm looking into to it as well. I'm still trying to understand more about peroxisome proliferator-activated receptors (PPARs) and their relation to retinol metabolism. Just came across this: https://www.ncbi.nlm.nih.gov/pubmed/18068127

As I mentioned, I only take PEA as needed, but it works for me (eliminates itching, pain, and insomnia, and even decreases headaches related to occasional high histamine and/or high vitamin A intake), and I haven't yet noticed any side effects.

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