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NAD+
Quote from
El on May 27, 2023, 3:02 am
grant does intermittent fasting maybe it's an important point
NAMPT protein, an enzyme necessary for the synthesis of NAD+, a key molecule in longevity and in the manufacture of cellular energy (ATP) from the electrons in food. Eating at night not only destroys the oscillation of its expression, but also annihilates its levels, generating a double and dangerous consequence:
The loss of effectiveness when it comes to metabolizing food.
A decrease in the activity of sirtuins, also known as the 7 longevity proteins (they depend on NAD+). David Sinclair, from Harvard, tells us that a person at 50 has their NAD+ levels cut in half compared to when they were 20 years old. We now know that intermittent fasting could prevent this from happening.
The second clue is provided by clinical studies on intermittent fasting: when you eat in the morning (early time restricted feeding) the advantages are greater than when the food windows are in the afternoon
grant does intermittent fasting maybe it's an important point
NAMPT protein, an enzyme necessary for the synthesis of NAD+, a key molecule in longevity and in the manufacture of cellular energy (ATP) from the electrons in food. Eating at night not only destroys the oscillation of its expression, but also annihilates its levels, generating a double and dangerous consequence:
The loss of effectiveness when it comes to metabolizing food.
A decrease in the activity of sirtuins, also known as the 7 longevity proteins (they depend on NAD+). David Sinclair, from Harvard, tells us that a person at 50 has their NAD+ levels cut in half compared to when they were 20 years old. We now know that intermittent fasting could prevent this from happening.
The second clue is provided by clinical studies on intermittent fasting: when you eat in the morning (early time restricted feeding) the advantages are greater than when the food windows are in the afternoon
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JennyAndrew BDeleted user
Quote from
El on May 27, 2023, 3:12 am
It is important to know these ways to know how to help your body produce NAD+.
In the body, NAD+ is produced in different tissues through the following pathways:
De novo synthesis pathway: This process begins with L-tryptophan, an amino acid that is converted to nicotinic acid mononucleotide (NAMN) through a series of enzymatic reactions. Next, nicotinic acid mononucleotide (NAMN) is converted to NAD+.
Preiss-Handler pathway: Here, niacin or vitamin B3 goes through several enzymatic reactions. This pathway also produces NAMN, as an intermediate molecule that is subsequently converted to NAD+.
Salvage pathway: The salvage pathway starts with nicotinamide (NAM) which is converted to nicotinamide mononucleotide (NMN) with the help of enzymatic reactions and finally to NAD+. The interesting thing about this pathway is that once the NAD+ is consumed, NMN is produced, which feeds the pathway back to reproduce the NAD+ in a recycled way
It is important to know these ways to know how to help your body produce NAD+.
In the body, NAD+ is produced in different tissues through the following pathways:
De novo synthesis pathway: This process begins with L-tryptophan, an amino acid that is converted to nicotinic acid mononucleotide (NAMN) through a series of enzymatic reactions. Next, nicotinic acid mononucleotide (NAMN) is converted to NAD+.
Preiss-Handler pathway: Here, niacin or vitamin B3 goes through several enzymatic reactions. This pathway also produces NAMN, as an intermediate molecule that is subsequently converted to NAD+.
Salvage pathway: The salvage pathway starts with nicotinamide (NAM) which is converted to nicotinamide mononucleotide (NMN) with the help of enzymatic reactions and finally to NAD+. The interesting thing about this pathway is that once the NAD+ is consumed, NMN is produced, which feeds the pathway back to reproduce the NAD+ in a recycled way
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JennyHermesAndrew BDonaldDeleted user
Quote from
El on May 27, 2023, 3:19 am
Being on intermittent fasting and zero sugar, I sense that Grant is in ketosis at a high time. burning glucose spends 4 NAD + burning ketones 1NAD+ or 0 if you depend on glucose and insulin the body depends more on NAD+ and they will run out much faster.
Being on intermittent fasting and zero sugar, I sense that Grant is in ketosis at a high time. burning glucose spends 4 NAD + burning ketones 1NAD+ or 0 if you depend on glucose and insulin the body depends more on NAD+ and they will run out much faster.
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JennyDeleted userDonaldDeleted user
Quote from
Jenny on May 27, 2023, 3:21 am
NAD+ is key. The body has many ways of recycling and making it. Plan A is the best way and once this fails the body relies on workarounds - plan B, C and D. These have consequences. De novo production is particularly prone to trouble - the tryptophan or kynurenine pathway - as if not running smoothly toxic intermediates can accumulate such as quinolinic acid (B6 deficiency a huge issue for this pathway). See my ‘NAD deficiency - is this a major issue for vA toxicity/detox?’ thread for lots of discussion on this.
I think NAD depletion could be behind the ‘detox setback cycle’ as I’ve discussed in above thread. The intermittent fasting/lack of sugar could be one reason why some people do better than others. @el thanks for bringing up this idea, it’s not something I’ve considered, but could be a really important difference between people. I think it’s important to understand why some people get short of NAD and others don’t. I’m thinking that mitochondrial health is key. But it’s all linked. We don’t want to drive ourselves into a low NAD state while doing the detox. Anything we can do to preserve NAD+ is going to help imo.
NAD+ is key. The body has many ways of recycling and making it. Plan A is the best way and once this fails the body relies on workarounds - plan B, C and D. These have consequences. De novo production is particularly prone to trouble - the tryptophan or kynurenine pathway - as if not running smoothly toxic intermediates can accumulate such as quinolinic acid (B6 deficiency a huge issue for this pathway). See my ‘NAD deficiency - is this a major issue for vA toxicity/detox?’ thread for lots of discussion on this.
I think NAD depletion could be behind the ‘detox setback cycle’ as I’ve discussed in above thread. The intermittent fasting/lack of sugar could be one reason why some people do better than others. @el thanks for bringing up this idea, it’s not something I’ve considered, but could be a really important difference between people. I think it’s important to understand why some people get short of NAD and others don’t. I’m thinking that mitochondrial health is key. But it’s all linked. We don’t want to drive ourselves into a low NAD state while doing the detox. Anything we can do to preserve NAD+ is going to help imo.
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HermesAndrew BDonaldDeleted userEl
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JennyHermesDeleted userEl
Quote from
El on May 27, 2023, 3:29 am
Quote from
Jenny on May 27, 2023, 3:21 am
NAD+ is key. The body has many ways of recycling and making it. Plan A is the best way and once this fails the body relies on workarounds - plan B, C and D. These have consequences. De novo production is particularly prone to trouble - the tryptophan or kynurenine pathway - as if not running smoothly toxic intermediates can accumulate such as quinolinic acid (B6 deficiency a huge issue for this pathway). See my ‘NAD deficiency - is this a major issue for vA toxicity/detox?’ thread for lots of discussion on this.
Creo que el agotamiento de NAD podría estar detrás del 'ciclo de retroceso de desintoxicación' como he discutido en el hilo anterior. El ayuno intermitente/la falta de azúcar podría ser una de las razones por las que a algunas personas les va mejor que a otras.
Perhaps your main fuel is sugar, even if you are in ketosis, can you be on a ketogenic diet as a vegetarian and the one that Grant does, but do you fast?
Quote from
Jenny on May 27, 2023, 3:21 am
NAD+ is key. The body has many ways of recycling and making it. Plan A is the best way and once this fails the body relies on workarounds - plan B, C and D. These have consequences. De novo production is particularly prone to trouble - the tryptophan or kynurenine pathway - as if not running smoothly toxic intermediates can accumulate such as quinolinic acid (B6 deficiency a huge issue for this pathway). See my ‘NAD deficiency - is this a major issue for vA toxicity/detox?’ thread for lots of discussion on this.
Creo que el agotamiento de NAD podría estar detrás del 'ciclo de retroceso de desintoxicación' como he discutido en el hilo anterior. El ayuno intermitente/la falta de azúcar podría ser una de las razones por las que a algunas personas les va mejor que a otras.
Perhaps your main fuel is sugar, even if you are in ketosis, can you be on a ketogenic diet as a vegetarian and the one that Grant does, but do you fast?
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Quote from
Jenny on May 27, 2023, 3:34 am
I was doing time restricted feeding but not intermittent fasting. This is an interesting aspect to think about. If only my brain was working better!
@andrew-b why am I incapable of doing links haha - I tried - thanks for adding.
I was doing time restricted feeding but not intermittent fasting. This is an interesting aspect to think about. If only my brain was working better!
@andrew-b why am I incapable of doing links haha - I tried - thanks for adding.
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HermesAndrew BDeleted user
Quote from
El on May 27, 2023, 3:37 am
Quote from
Jenny on May 27, 2023, 3:34 am
I was doing time restricted feeding but not intermittent fasting. This is an interesting aspect to think about. If only my brain was working better!
@andrew-b why am I incapable of doing links haha - I tried - thanks for adding.
Grant only eats twice a day. Nobody did Grant's diet eating only twice a day? Maybe that's the solution fasting increases NAD + and that's why Grant doesn't have detoxification symptoms grant diet plus fasting maybe this is the key in that
Quote from
Jenny on May 27, 2023, 3:34 am
I was doing time restricted feeding but not intermittent fasting. This is an interesting aspect to think about. If only my brain was working better!
@andrew-b why am I incapable of doing links haha - I tried - thanks for adding.
Grant only eats twice a day. Nobody did Grant's diet eating only twice a day? Maybe that's the solution fasting increases NAD + and that's why Grant doesn't have detoxification symptoms grant diet plus fasting maybe this is the key in that
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JennyHermesAndrew BDeleted userHenrik
Quote from
El on May 27, 2023, 3:42 am
Quote from
Jenny on May 27, 2023, 3:34 am
I was doing time restricted feeding but not intermittent fasting. This is an interesting aspect to think about. If only my brain was working better!
@andrew-b why am I incapable of doing links haha - I tried - thanks for adding.
also think that fasting and a ketogenic diet is fine. African natives who eat carnivore eat probiotics, that is, fermented vegetables that are low in fiber but rich in bifiobacteria. Bifiobacteria regulate intestinal transit and therefore you go several times a day. fasting and ketogenic you can accumulate toxones very quickly. You need fiber or foods that kill the bifibacteria, as fats deplete the bifibacteria. that's why people in keto or carnivore go to the bathroom little.
Quote from
Jenny on May 27, 2023, 3:34 am
I was doing time restricted feeding but not intermittent fasting. This is an interesting aspect to think about. If only my brain was working better!
@andrew-b why am I incapable of doing links haha - I tried - thanks for adding.
also think that fasting and a ketogenic diet is fine. African natives who eat carnivore eat probiotics, that is, fermented vegetables that are low in fiber but rich in bifiobacteria. Bifiobacteria regulate intestinal transit and therefore you go several times a day. fasting and ketogenic you can accumulate toxones very quickly. You need fiber or foods that kill the bifibacteria, as fats deplete the bifibacteria. that's why people in keto or carnivore go to the bathroom little.
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Quote from
El on May 27, 2023, 3:47 am
grant's diet is perfect low poison moderate to low fat, fasting and high fiber
grant's diet is perfect low poison moderate to low fat, fasting and high fiber
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JennyHermesDeleted userHenrik
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