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NAD+
Being in ketosis and fasting make you constantly burn fat. therefore fat-soluble toxins are in constant circulation and accumulating in the liver or intestinal tract. If you don't go several times a day you will end up badly. and for that you need bifiobacteria and fats lower it to 0. Ketogenic diet high in fat and without fiber... it will hurt you. during fasting you can take the fiber-rich pylium husk that does not take away the benefits of fasting
and finally the African natives become carnivorous yes. but game meat is very very low in fat. that is, they eat little fat, not much. Your diet is rich in protein and foods that grow your population of bifiobacteria. Animals from civilized countries are rich in fat and protein. They are toxic animals. we eat all their poisons. Animals have to be wild. or just eat muscle meat
I would caution about unusually manipulating NAD+. Yes, it is necessary, but too much especially in the liver can cause a deluge for the body to deal with.
I recently was messing with some doses of Niacinamide in the 100mg range, and it seemed to bring on a sleuth of symptoms including tinnitus, then a bit of constipation, then (after taking some Mg and Sunfiber), some oddly colored stools and tinnitus relief.
Given Grant's recent post on this, I feel like it's a dead ringer. The added Niacin probably increased the toxicity of the bile and caused cholestasis.
Once resumed, the additional detoxed VitA compounds (wonder which forms???) flooded out until things came back to normal.
I wish there was a way to defang the whole route out, lubricate the bile ducts, biliary tubes, and catch it all in the intestines.
Oh, well...back to slow
@ggenereux
please give me a link that pegs Grant's diet as low carb let alone ketogenic. This is the first time I heard anything about Grant being in ketosis.
While I think it would be interesting to see if feeding frequency seems to generate a reliable vector for all the detoxsymptoms, ketosis needs carb-restriction for at least 18 hours to occure (and thus excludes Grants regime)- and we are then talking almost zero carb, if not it takes longer. I dont exclude that the burning of triglycerides starting after 3 or 4 hours after last feeding might impact stuff as at least we know that retinol is fat-soluble. https://www.healthline.com/nutrition/stages-of-fasting