I suppose this isn't any news, but I guess it reinforces Garrett's theory that ancient tribes prized liver not because (or not just because) it was a nutrient powerhouse, but it was also the easiest part of the animal to eat. If that weren't the case, why would cases like this one consciously keep eating in a way that makes them sick?
Just stumbled across this video while browsing youtube with my two brain cells:
I suppose this isn't any news, but I guess it reinforces Garrett's theory that ancient tribes prized liver not because (or not just because) it was a nutrient powerhouse, but it was also the easiest part of the animal to eat. If that weren't the case, why would cases like this one consciously keep eating in a way that makes them sick?
The trouble with A is not just toxicity(continuously throwing of A over microbiome by the lazy immune system with a persistent collateral damage) .. for example some chronic pathogens (EBV/CMV) developed the way of spreading through our cells by using retinol to aid them:
The trouble with A is not just toxicity(continuously throwing of A over microbiome by the lazy immune system with a persistent collateral damage) .. for example some chronic pathogens (EBV/CMV) developed the way of spreading through our cells by using retinol to aid them:
When I think about that Paleo woman, I wonder to myself just how long would it take to fix those bones of hers? (which I'm sure was not her only symptom).
It certainly isn't a fix of a few weeks and maybe isn't a fix of a few years. This toxicity goes all they way down through her bones. How long to detox and then to rebuild?
I've been sweating a lot this week, so hot. Here I am at 2 years and still itchy as ever. I bet Paleo woman was itchy.
When I think about that Paleo woman, I wonder to myself just how long would it take to fix those bones of hers? (which I'm sure was not her only symptom).
It certainly isn't a fix of a few weeks and maybe isn't a fix of a few years. This toxicity goes all they way down through her bones. How long to detox and then to rebuild?
I've been sweating a lot this week, so hot. Here I am at 2 years and still itchy as ever. I bet Paleo woman was itchy.
I have read that in an adult, about 10% of your skeleton is renewed/regenerated per year. So, it takes an adult skeleton about 10 years to fully renew.
So, it is most likely going to take many years of eating a low Vitamin A diet to help with a significant bone problem that was caused by Vitamin A toxicity.
I have read that in an adult, about 10% of your skeleton is renewed/regenerated per year. So, it takes an adult skeleton about 10 years to fully renew.
So, it is most likely going to take many years of eating a low Vitamin A diet to help with a significant bone problem that was caused by Vitamin A toxicity.
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A long time ago I saw a grave marked "I told you I was sick" LOL. I feel for paleo woman because she probably kept telling the people around her that she felt "delicate" and "unwell" and like she couldn't rely on her body to "be normal"... But having spongy bones is invisible.
A long time ago I saw a grave marked "I told you I was sick" LOL. I feel for paleo woman because she probably kept telling the people around her that she felt "delicate" and "unwell" and like she couldn't rely on her body to "be normal"... But having spongy bones is invisible.
Modern hunter gatherers like the Hadza prize the liver. I doubt there is any direct evidence, like liver biopsies, about vitamin A toxicity in modern hunter gatherers. Modern hunter gatherers clearly lack the main chronic diseases associated with western civilization. I believe there are few carnivores like lions and tigers for modern hunter gatherers to hunt, as the big carnivores are mostly kept in national parks. Also, the herbivores being hunted are smaller than before for similar reasons: the big game is only in national parks.
Some possibilities:
Something else in our diet or environment is making it harder for us to detox vitamin A than for hunter gatherers.
Low vitamin A intake: Hunter gatherers only eat liver after a successful hunt and share the liver amongst a band of people living together. They also don't eat other high vitamin A foods like colorful vegetables and dairy and eat eggs infrequently.
Early death from causes other than vitamin A toxicity. This is controversial as many think lifespans for those who reach 18 are not low among hunter gatherers.
Modern hunter gatherers like the Hadza prize the liver. I doubt there is any direct evidence, like liver biopsies, about vitamin A toxicity in modern hunter gatherers. Modern hunter gatherers clearly lack the main chronic diseases associated with western civilization. I believe there are few carnivores like lions and tigers for modern hunter gatherers to hunt, as the big carnivores are mostly kept in national parks. Also, the herbivores being hunted are smaller than before for similar reasons: the big game is only in national parks.
Some possibilities:
Something else in our diet or environment is making it harder for us to detox vitamin A than for hunter gatherers.
Low vitamin A intake: Hunter gatherers only eat liver after a successful hunt and share the liver amongst a band of people living together. They also don't eat other high vitamin A foods like colorful vegetables and dairy and eat eggs infrequently.
Early death from causes other than vitamin A toxicity. This is controversial as many think lifespans for those who reach 18 are not low among hunter gatherers.
I think that genetic differences are the most likely explanation. There seems to be quite a bit of variation in the ability to metabolize vitamin A among people whose ancestors have consumed agricultural diets which is a similar pattern to lactase persistence. Although lactase persistence is high in northern european people, it's not universal. I suspect that through the Neolithic many have made genetic adaptations that more efficiently conserve vitamin A or many have genetically lost the ability to efficiently metabolize vitamin A, the genetic expression of these changes probably isn't universal either. Perhaps that also explains why many are so averse to liver but some aren't.
In hunter gather societies there is a survival advantage to being able to quickly metabolize vitamin A. In agricultural societies the vitamin A content of the diet is much lower, most of the world still consumes a diet that contains significantly less than the RDA despite efforts being made to increase vitamin A intake and awareness about vitamin A. For example, the median intake of vitamin A in Mexico is about 1/6th of the RDA. In the past vitamin A consumption would have been even lower in general. This would have greatly reduced the survival advantage for being able to quickly metabolize vitamin A and there may have been a survival advantage in being able to more efficiently conserve vitamin A.
I think that genetic differences are the most likely explanation. There seems to be quite a bit of variation in the ability to metabolize vitamin A among people whose ancestors have consumed agricultural diets which is a similar pattern to lactase persistence. Although lactase persistence is high in northern european people, it's not universal. I suspect that through the Neolithic many have made genetic adaptations that more efficiently conserve vitamin A or many have genetically lost the ability to efficiently metabolize vitamin A, the genetic expression of these changes probably isn't universal either. Perhaps that also explains why many are so averse to liver but some aren't.
In hunter gather societies there is a survival advantage to being able to quickly metabolize vitamin A. In agricultural societies the vitamin A content of the diet is much lower, most of the world still consumes a diet that contains significantly less than the RDA despite efforts being made to increase vitamin A intake and awareness about vitamin A. For example, the median intake of vitamin A in Mexico is about 1/6th of the RDA. In the past vitamin A consumption would have been even lower in general. This would have greatly reduced the survival advantage for being able to quickly metabolize vitamin A and there may have been a survival advantage in being able to more efficiently conserve vitamin A.
@ourania I think sympathetic activation is huge. To your list I’ll add: glyphosate, medications, all sorts of heavy metal toxicity, so much other increased toxicity in the environment, supplements. That’s just for starters. Our environment is incomparable with the environment when I was a child. No such thing as organic food then as it was all organic. I think they started with the glyphosate nonsense in the 70s and increased it in the 90s. That one thing is massive.
@ourania I think sympathetic activation is huge. To your list I’ll add: glyphosate, medications, all sorts of heavy metal toxicity, so much other increased toxicity in the environment, supplements. That’s just for starters. Our environment is incomparable with the environment when I was a child. No such thing as organic food then as it was all organic. I think they started with the glyphosate nonsense in the 70s and increased it in the 90s. That one thing is massive.
I think that genetic differences are the most likely explanation. There seems to be quite a bit of variation in the ability to metabolize vitamin A among people whose ancestors have consumed agricultural diets which is a similar pattern to lactase persistence.
Is this idea coming from academic studies on metabolizing vitamin A or you own conjecture?
I think that genetic differences are the most likely explanation. There seems to be quite a bit of variation in the ability to metabolize vitamin A among people whose ancestors have consumed agricultural diets which is a similar pattern to lactase persistence.
Is this idea coming from academic studies on metabolizing vitamin A or you own conjecture?
