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Phosphatidylcholine is crucial to toxic bile theory
Quote from
Andrew B on August 29, 2024, 12:59 am
This is what has been known for some time. Some people are low in choline. PC helps protect against the toxicity of bile salts, protects the liver and bile ducts and helps bile flow. Both fibre and phosphatidylcholine are helpful for successful reduction of toxic bile. PC might be essential it seems. Fibre some people say isnt essential. PC helps resolve fatty liver by removing the fat in the bile. It also helps fat digestion.
Bile acid metabolism and signaling. Phosphatidylcholine plays a crucial role in toxic bile theory. Excerpts:
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CDCA more efficiently forms mixed micelles with cholesterol and phosphatidylcholine and, therefore, the CA/CDCA ratio may affect the risk of gallstone formation.
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Conjugated primary bile acids do not exhibit cytotoxic effects at concentrations close to physiological conditions. In the presence of phosphatidylcholine, cholesterol, the concentration of primary bile acids, which are freely present in the aqueous phase, sharply decrease, as they form single-layer bubbles and mixed micelles, in which the hydrophobic regions of the molecules are enclosed. This explains why the primary bile acids in the biliary tract and small intestine do not display cytotoxic effects.
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At a concentration close to the amount required for the formation of micelles, membrane damage is possible. A deficiency of phosphatidylcholine in bile can increase the content of primary bile acids, which are freely present in the aqueous phase (monomers) leading to the damage of cholangiocytes. [121]. The secretion of HCO3− by the biliary epithelium creates a protective bicarbonate umbrella on its surface, which neutralizes bile acids and reduces their ability to penetrate the cell surface [96]
Toxic bile theory without discussing the importance of phosphatidylcholine ? AI: Yes, phosphatidylcholine (PC) plays a crucial role in the toxic bile theory. This theory suggests that an imbalance in bile composition, particularly a deficiency in phosphatidylcholine, can lead to liver and bile duct damage. Here are some key points:
1. Protection Against Bile Salts: Phosphatidylcholine helps protect the intestinal and biliary epithelium from the detergent-like effects of bile salts. It forms mixed micelles with bile acids, reducing their toxicity12.
2. Liver Protection: PC is essential for the excretion of bile acids and cholesterol. A deficiency in PC can lead to the accumulation of toxic bile acids, causing liver damage3.
3. Cholestatic Liver Diseases: In conditions like cholestasis, where bile flow is impaired, the lack of PC can exacerbate liver and bile duct injury2.
In summary, phosphatidylcholine is vital for maintaining bile composition and protecting the liver and bile ducts from damage. If you have more questions or need further details, feel free to ask!
This is what has been known for some time. Some people are low in choline. PC helps protect against the toxicity of bile salts, protects the liver and bile ducts and helps bile flow. Both fibre and phosphatidylcholine are helpful for successful reduction of toxic bile. PC might be essential it seems. Fibre some people say isnt essential. PC helps resolve fatty liver by removing the fat in the bile. It also helps fat digestion.
Bile acid metabolism and signaling. Phosphatidylcholine plays a crucial role in toxic bile theory. Excerpts:
-
CDCA more efficiently forms mixed micelles with cholesterol and phosphatidylcholine and, therefore, the CA/CDCA ratio may affect the risk of gallstone formation.
-
Conjugated primary bile acids do not exhibit cytotoxic effects at concentrations close to physiological conditions. In the presence of phosphatidylcholine, cholesterol, the concentration of primary bile acids, which are freely present in the aqueous phase, sharply decrease, as they form single-layer bubbles and mixed micelles, in which the hydrophobic regions of the molecules are enclosed. This explains why the primary bile acids in the biliary tract and small intestine do not display cytotoxic effects.
-
At a concentration close to the amount required for the formation of micelles, membrane damage is possible. A deficiency of phosphatidylcholine in bile can increase the content of primary bile acids, which are freely present in the aqueous phase (monomers) leading to the damage of cholangiocytes. [121]. The secretion of HCO3− by the biliary epithelium creates a protective bicarbonate umbrella on its surface, which neutralizes bile acids and reduces their ability to penetrate the cell surface [96]
Toxic bile theory without discussing the importance of phosphatidylcholine ? AI: Yes, phosphatidylcholine (PC) plays a crucial role in the toxic bile theory. This theory suggests that an imbalance in bile composition, particularly a deficiency in phosphatidylcholine, can lead to liver and bile duct damage. Here are some key points:
1. Protection Against Bile Salts: Phosphatidylcholine helps protect the intestinal and biliary epithelium from the detergent-like effects of bile salts. It forms mixed micelles with bile acids, reducing their toxicity12.
2. Liver Protection: PC is essential for the excretion of bile acids and cholesterol. A deficiency in PC can lead to the accumulation of toxic bile acids, causing liver damage3.
3. Cholestatic Liver Diseases: In conditions like cholestasis, where bile flow is impaired, the lack of PC can exacerbate liver and bile duct injury2.
In summary, phosphatidylcholine is vital for maintaining bile composition and protecting the liver and bile ducts from damage. If you have more questions or need further details, feel free to ask!
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Deleted userSaschaRetinoiconDeleted userAndreas
Quote from
grapes on September 1, 2024, 4:00 am
@andrew-b Why privilege egg consumption over choline supplementation? i agree that in general it is better to obtain nutrients from natural sources, but in this case the food presents a risk of further vitamin A accumulation.
@andrew-b Why privilege egg consumption over choline supplementation? i agree that in general it is better to obtain nutrients from natural sources, but in this case the food presents a risk of further vitamin A accumulation.
Retinoicon and Andrew B have reacted to this post.
Quote from
Andrew B on September 1, 2024, 4:16 am
@grapes I increased egg consumption to 3-4 eggs a day. I'm not a fan of supplementing (eggs can fine tune it whereas supplements are a big hammer some times). I also use eggs for baking in a number of things. I only did the experiment with eggs. Now 2.3 years on 3 eggs a day on average. Egg choline is in the form of phosphatidylcholine (PC) which is a help to an ill person not converting choline to PC very well. Egg choline is better absorbed. Eggs were cheap at the time. Eggs contain biotin, selenium and iodine which saves supplementing those to some extent. Biotin may be helping PC synergistically so taking a single supplement may miss what I actually did. Average Vitamin A metabolism is much better at reducing excess Vitamin A than eggs at 75 mcgs per eggs. I tend to use IUs but it's somewhere between 10-20,000 IUs we may be capable of metabolising each day. Hence at about 30,000 IUs per day for long time we may get into trouble. This is taken from the 1982 Weber study of 1 man with liver biopsies which is all we have to tell. Accumulating eggs at 75 mcgs of vA hypothetically would take 400 years to build up to 10.95 million mcgs even if metabolism wasnt working at all.
@grapes I increased egg consumption to 3-4 eggs a day. I'm not a fan of supplementing (eggs can fine tune it whereas supplements are a big hammer some times). I also use eggs for baking in a number of things. I only did the experiment with eggs. Now 2.3 years on 3 eggs a day on average. Egg choline is in the form of phosphatidylcholine (PC) which is a help to an ill person not converting choline to PC very well. Egg choline is better absorbed. Eggs were cheap at the time. Eggs contain biotin, selenium and iodine which saves supplementing those to some extent. Biotin may be helping PC synergistically so taking a single supplement may miss what I actually did. Average Vitamin A metabolism is much better at reducing excess Vitamin A than eggs at 75 mcgs per eggs. I tend to use IUs but it's somewhere between 10-20,000 IUs we may be capable of metabolising each day. Hence at about 30,000 IUs per day for long time we may get into trouble. This is taken from the 1982 Weber study of 1 man with liver biopsies which is all we have to tell. Accumulating eggs at 75 mcgs of vA hypothetically would take 400 years to build up to 10.95 million mcgs even if metabolism wasnt working at all.
grapes, Hermes and Retinoicon have reacted to this post.
Quote from
grapes on September 1, 2024, 4:55 am
@andrew-b Thanks for the reply, does the egg cooking method matter?
@andrew-b Thanks for the reply, does the egg cooking method matter?
Andrew B has reacted to this post.
Quote from
Andrew B on September 1, 2024, 5:02 am
@grapes I only ever lightly fry the eggs to whiten the egg white part without heating yolk too much. I only tend to fry one egg a day (sometimes 2 when I do 4 a day). So it would seem that baking 2 eggs in various things at moderate temperatures didnt reduce the benefits too much.
@grapes I only ever lightly fry the eggs to whiten the egg white part without heating yolk too much. I only tend to fry one egg a day (sometimes 2 when I do 4 a day). So it would seem that baking 2 eggs in various things at moderate temperatures didnt reduce the benefits too much.
grapes and Hermes have reacted to this post.
