Quote from
ggenereux on February 2, 2020, 8:05 am
Here’s a study showing that RA (13-cis-retinoic acid) causes depression by impairments of the the glucocorticoid receptor negative feedback loop.
All-trans retinoic acid-induced hypothalamus–pituitary–adrenal hyperactivity involves glucocorticoid receptor dysregulation
Clinical evidence shows that treatment with 13-cis-RA in a restricted dose range as low as 0.5–1 mg kg−1 per day can cause depression in susceptible individuals.
my bet is that we are all "susceptible individuals"; it's really just a matter of dose and time.
In humans, such maladaptive changes in the HPA axis after excessive RA treatment or vitamin A consumption may set the stage for stress-related neuropsychiatric disorders.
Next, here’s a study showing that retinoic acid increases cortisol secretion
Effect of retinoic acid on human adrenal corticosteroid synthesis
Significance
Retinoic acid stimulates cortisol synthesis and secretion in human adrenals and at the same time markedly blunts ACTH receptor transcription. These results reveal a novel, adrenal effect of retinoic acid which may contribute to its efficacy in patients with Cushing's disease.
And, here’s a good article by Dr. Jason Fung documenting the causal connection between chronic elevation of cortisol and obesity.
A Closer Look at Cortisol
This also might help explain the insomnia and poor sleep many people have reported.
Here’s a study showing that RA (13-cis-retinoic acid) causes depression by impairments of the the glucocorticoid receptor negative feedback loop.
All-trans retinoic acid-induced hypothalamus–pituitary–adrenal hyperactivity involves glucocorticoid receptor dysregulation
Clinical evidence shows that treatment with 13-cis-RA in a restricted dose range as low as 0.5–1 mg kg−1 per day can cause depression in susceptible individuals.
my bet is that we are all "susceptible individuals"; it's really just a matter of dose and time.
In humans, such maladaptive changes in the HPA axis after excessive RA treatment or vitamin A consumption may set the stage for stress-related neuropsychiatric disorders.
Next, here’s a study showing that retinoic acid increases cortisol secretion
Effect of retinoic acid on human adrenal corticosteroid synthesis
Significance
Retinoic acid stimulates cortisol synthesis and secretion in human adrenals and at the same time markedly blunts ACTH receptor transcription. These results reveal a novel, adrenal effect of retinoic acid which may contribute to its efficacy in patients with Cushing's disease.
And, here’s a good article by Dr. Jason Fung documenting the causal connection between chronic elevation of cortisol and obesity.
A Closer Look at Cortisol
This also might help explain the insomnia and poor sleep many people have reported.
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