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Retinoic acid, nitric oxide & sensitive skin
I just listened to a podcast with Dr. Ray Peat. He happened to mention that people who's skin turns red and is marked easily produce more nitric oxide.
Lets assume that this is true and look for a connection: 'Nitric Oxide Retinoic Acid pubmed'...
- All‑trans retinoic acid reduces endothelin‑1 expression and increases endothelial nitric oxide synthase phosphorylation in rabbits with atherosclerosis.
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Differential effects of retinoids on nitric oxide production by promonocytic U937 cells and ZR-75-1 human breast cancer cells. ("Our results indicate that retinoid induced growth inhibition of breast cancer cells is associated with an increase in NO production")
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Retinoic acid activates human inducible nitric oxide synthase gene through binding of RARalpha/RXRalpha heterodimer to a novel retinoic acid response element in the promoter.
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All-trans-retinoic acid modulates nitric oxide and interleukin-17A production by peripheral blood mononuclear cells from patients with Alzheimer's disease.
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all-trans-Retinoic acid increases nitric oxide synthesis by endothelial cells: a role for the induction of dimethylarginine dimethylaminohydrolase.
There was a lot more. To be fair, there was one study that found a decrease synthesis of NO due to retinoic acid. I didn't read it properly, but that was the title.
If it is true that people with sensitive skin produce more Nitric Oxide, we now know why.
Hello Harry,
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115935/
did you see this one from August 2018, the final remarks are very interesting.
Hi John,
That's very interesting, thank for sharing. One of those one's where the closing remarks seem to contradict everything else that is said in the study. So much science is conducted on the basis of preconceived notions about a substance's beneficial/essential nature. That means that any observation or discovered mechanism is always interpreted as beneficial or necessary. However, if the preconceived notions of the substance's nature are misplaced assumptions without a basis, this does little to advance our understanding of anything. I think this could be the case with RA.
I thought I'd post the key sentences here, just to have them available for the casual reader that stops by for a quick visit. The PubMed article linked is titled: Retinoic Acid, Leaky Gut, and Autoimmune Diseases. In part 6 - Concluding Remarks and Future Directions - it states:
"Furthermore, although beyond the scope of our review, evidence exists linking RA toxicity to several acute and chronic diseases [233,234]. There is also evidence that RA can cause a temporary feedback inhibition to the production of endogenous RA itself [235,236] Therefore, many of the short-term observations described in our review may be temporary consequences due to the feedback inhibitory effect of RA and that longer-term observations could actually reveal toxic effects that may, in fact, indicate a causal role for RA in these same autoimmune diseases."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115935/
Forgot to log-in on that post above. I hope to have further things to say about some of these PubMed published studies, since I have quite a bit of time lately to dive in, print them out, highlight questionable statements and identify where it looks like a spin is being created under the "color of science". I read 5 today, from ophthalmology to gastroenterology to dermatology, and it's obvious the slant/bias is figuring out how to create new drugs to impact the immune system. Wouldn't it be great if large numbers of us were chewing up these studies, becoming conversant in the language, and collaborating to identify inherent contradictions between them.
One topic I really want to focus upon is Taurine, to look more closely at the amounts used in experiments, how it actually interacts with Retinoic Acid, and human studies, if any. Suggestions from anyone whose been at this awhile are appreciated.
Taurine is known to benefit the liver. It also has antioxidant properties. Since retinol is unsaturated, it can oxidise easily; it is also stored in the liver. That's probably something to do with it's benefit in this context. I think there's generally a fall-off after 1.5g, in terms of benefits.
Re: the focus of studies: I read one recently that was talking about specific properties of palmitic acid (a saturated fat) to antagonise RA, and how this might have anti-cancer potential. The next sentence they basically went on to say, "so if we can find a drug that does the same thing, we might have a viable treatment". Unfortunately, this is just how things work.
Thanks Harry - I just started taking Taurine in powder form.
This study from 2016 describes the same process Grant explains occurs in eczema. Destruction of the stem cell area and thickening of the outer epithelium.
Ocular Surface Epithelial Thickness Evaluation in Dry Eye Patients: Clinical Correlations
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746380/
Hi Harry. I was told you have a website and do consultations. What is the website address?
Quote from Guest on February 19, 2019, 2:51 pmHi Harry. I was told you have a website and do consultations. What is the website address?
Hi there.
Yes - http://www.elementalhtma.co.uk. You can contact me at harry@elementalhtma.co.uk.