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Retinol and ferroxidase
When surfing internet I found following comment that picked my interest:
Ferritin is NOT a measure of iron. We have to advance beyond that and any amount of iron supplements are dangerous. You want the ferritin low. Iron is supposed to always be in motion and is monitored by the Ferroxidase enzyme.
And vit D supplementation deplete retinol necessary for ferroxidase function. Its dangerous to advice hormone D supplementation.
I already read in many places that too much iron is bad so I looked a little around and it's way over the top for me so I will simply leave links here for people that are more knowledgeable than me:
In this Hepcidin: Homeostasis and Diseases Related to Iron Metabolism I found this text:
In other studies investigating vitamin A and its relationship with iron metabolism in Mus musculus rats treated with retinol palmitate (4,000 IU/kg) for 22 days, the treatment increased the mRNA levels of hepcidin and ferritin, favouring the accumulation of iron in the liver, as well as increased oxidative and inflammatory stress [77–79].
Referenced studies:
77 Arruda SF, Siqueira EM, de Valência FF: Vitamin A deficiency increases hepcidin expression and oxidative stress in rat. Nutrition 2009; 25: 472–478.
78 Citelli M, Bittencourt LL, da Silva SV, Pierucci AP, Pedrosa C: Vitamin A modulates the expression of genes involved in iron bioavailability. Biol Trace Elem Res 2012; 149: 64–70.
79 da Cunha MS, Siqueira EM, Trindade LS, Arruda SF: Vitamin A deficiency modulates iron metabolism via ineffective erythropoiesis. J Nutr Biochem 2014; 25: 1035–1044.
And I even found page where someone is having theory that all autoimmuno dissases are created by too much iron:
Author is referencing some studies there and here you have some quotes:
And what these many studies are seeking to reveal is that the regulation of Iron relies on two KEY pathways for optimal Iron circulation & R.E.cycling:
o Ferroportin<>Hepcidin System, but they are SILENT on the fact that this System does NOT work without Bioavailable Copper in the form of Ferroxidase enzyme function…
o Iron Regulatory Proteins (IRP1-2) and Iron Response Elements (IREs) System, but they are SILENT on the fact that this System responds EQUALLY well to Retinol (Animal-based Vitamin-A) JUST AS WELL as is does to Iron supplementation… And what is FASCINATING about that ^^^^ factoid is that Retinol is KEY & FOUNDATIONAL for the synthesis of Ferroxidase enzyme need above…We are “D”rowning in Hormone-D supplements – that KILL Retinol status in the Liver!…
We are “D”rowning in Iron Supplements & Infusions – that KILL our metabolism!…
We are “D”rowning in Zinc Supplements that CAUSE Copper to be bound up, and NOT available…
We are “D”rowning in Ascorbic Acid Supplements that INCREASE H2O2 (which TWEAKS the Ceruloplasmin protein & KILLS the Ferroxidase function) and ACCELERATES Iron STORAGE…
Maybe you will find it useful.
I think Morley Robbins is right about some things, but he is way off on vitamin a. He pushes cod liver oil, liver, and vit a supplements. He thinks the d supplements everyone takes has killed all our retinol and we are retinol deficient. I agree with not taking d supplements (rat poison), but his high a diet is dangerous. He thinks iron is source of most problems. I agree iron is an issue but grant makes a much better case for vit a. Hopefully Morley will come around. I took a lot of CLO and a supplements following his advice, luckily it was only for a few months before I found grants work.