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Riboflavin deficiency and vision
Quote from
tim on December 25, 2019, 5:49 pm
Riboflavin in vision
Corneal vascularization and corneal opacity have been described in animals fed diets low in riboflavin. Cataracts have also been described in animals fed riboflavin-deficient diets (132, 133). The importance of riboflavin deficiency in the etiology of cataracts in elderly humans is not fully understood (134). More recently, it was hypothesized that riboflavin deficiency may be associated with night blindness in some communities and that improving riboflavin status might enhance the improvement in night blindness evoked by vitamin A. Venkataswamy (135) reported riboflavin-responsive night blindness in India. Riboflavin-dependent photoreceptors (cryptochromes) identified in the retina are thought to play a role in the process of dark adaptation (136, 137). Dietary riboflavin might influence dark adaptation through these photoreceptors, through interaction with vitamin A, or independently. This is an area that deserves further attention.
https://academic.oup.com/ajcn/article/77/6/1352/4689829
Riboflavin in vision
Corneal vascularization and corneal opacity have been described in animals fed diets low in riboflavin. Cataracts have also been described in animals fed riboflavin-deficient diets (132, 133). The importance of riboflavin deficiency in the etiology of cataracts in elderly humans is not fully understood (134). More recently, it was hypothesized that riboflavin deficiency may be associated with night blindness in some communities and that improving riboflavin status might enhance the improvement in night blindness evoked by vitamin A. Venkataswamy (135) reported riboflavin-responsive night blindness in India. Riboflavin-dependent photoreceptors (cryptochromes) identified in the retina are thought to play a role in the process of dark adaptation (136, 137). Dietary riboflavin might influence dark adaptation through these photoreceptors, through interaction with vitamin A, or independently. This is an area that deserves further attention.
https://academic.oup.com/ajcn/article/77/6/1352/4689829
Quote from
tim on December 25, 2019, 6:58 pm
Phrynoderma: a manifestation of vitamin A deficiency?... The rest of the story.
Abstract
Phrynoderma is a distinctive form of follicular hyperkeratosis associated with nutritional deficiency. Although originally thought to represent vitamin A deficiency, several studies have demonstrated multiple etiologies. Characteristic skin lesions are hyperkeratotic papules that first appear on the extensor surfaces of the extremities, shoulders, and buttocks. We report a 14-month-old boy with malnourishment and hyperkeratotic papules and plaques with histologic changes typical of phrynoderma. Despite an extensive evaluation, a specific nutritional deficiency was not identified. Phrynoderma is believed to be a manifestation of severe malnutrition, not necessarily accompanying low vitamin A levels. While the literature supports a link between phrynoderma and vitamins E, B, A, and essential fatty acids general malnutrition seems to be the strongest association. The clinical picture typically improves with enhanced nutritional status. Phrynoderma must be considered in the differential diagnosis in patients with extensor surface hyperkeratotic papules and plaques in the setting of malnourishment and should prompt the clinician to evaluate cell markers of nutritional status, not just vitamin A. We believe this patient exemplifies the conundrum that faces clinicians in evaluating patients with extensor surface predominant hyperkeratotic papules and plaques in the setting of malnourishment.
https://www.ncbi.nlm.nih.gov/pubmed/15660900
A VAD symptom that isn't one.
Phrynoderma: a manifestation of vitamin A deficiency?... The rest of the story.
Abstract
Phrynoderma is a distinctive form of follicular hyperkeratosis associated with nutritional deficiency. Although originally thought to represent vitamin A deficiency, several studies have demonstrated multiple etiologies. Characteristic skin lesions are hyperkeratotic papules that first appear on the extensor surfaces of the extremities, shoulders, and buttocks. We report a 14-month-old boy with malnourishment and hyperkeratotic papules and plaques with histologic changes typical of phrynoderma. Despite an extensive evaluation, a specific nutritional deficiency was not identified. Phrynoderma is believed to be a manifestation of severe malnutrition, not necessarily accompanying low vitamin A levels. While the literature supports a link between phrynoderma and vitamins E, B, A, and essential fatty acids general malnutrition seems to be the strongest association. The clinical picture typically improves with enhanced nutritional status. Phrynoderma must be considered in the differential diagnosis in patients with extensor surface hyperkeratotic papules and plaques in the setting of malnourishment and should prompt the clinician to evaluate cell markers of nutritional status, not just vitamin A. We believe this patient exemplifies the conundrum that faces clinicians in evaluating patients with extensor surface predominant hyperkeratotic papules and plaques in the setting of malnourishment.
https://www.ncbi.nlm.nih.gov/pubmed/15660900
A VAD symptom that isn't one.
Quote from
lil chick on December 26, 2019, 9:02 am
from the google machine, just the quickest blurb available, seems so similar to some of the symptoms we see on the "high VA list" and the "detox symptoms list": the signs and symptoms of riboflavin deficiency (also known as ariboflavinosis) include skin disorders, hyperemia (excess blood) and edema of the mouth and throat, angular stomatitis (lesions at the corners of the mouth), cheilosis (swollen, cracked lips), hair loss, reproductive problems, sore throat, itchy and red eyes, and degeneration of the liver and nervous system.
Excess blood... gosh...makes me wonder about the heart pounding sensations written about often here
I wonder if the first article you've posted suggests that night blindness can be added to this list
from the google machine, just the quickest blurb available, seems so similar to some of the symptoms we see on the "high VA list" and the "detox symptoms list": the signs and symptoms of riboflavin deficiency (also known as ariboflavinosis) include skin disorders, hyperemia (excess blood) and edema of the mouth and throat, angular stomatitis (lesions at the corners of the mouth), cheilosis (swollen, cracked lips), hair loss, reproductive problems, sore throat, itchy and red eyes, and degeneration of the liver and nervous system.
Excess blood... gosh...makes me wonder about the heart pounding sensations written about often here
I wonder if the first article you've posted suggests that night blindness can be added to this list
