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Serum retinyl esters are positively correlated with liver vitamin A reserves
Link to the study
The authors suggest that if 7.5% or more of your total serum vitamin A is composed of retinyl esters, then indicates toxicity.
The conclusion contains this telling remark: "The long-term impact of VA supplements and fortificants on VA status is currently unknown. Considering the high prevalence of hypervitaminotic TLRs in this cohort, and given that many countries are adding preformed VA to processed products, population biomarkers diagnosing hypervitaminosis before toxicity are urgently needed."
Link to the study
The authors suggest that if 7.5% or more of your total serum vitamin A is composed of retinyl esters, then indicates toxicity.
The conclusion contains this telling remark: "The long-term impact of VA supplements and fortificants on VA status is currently unknown. Considering the high prevalence of hypervitaminotic TLRs in this cohort, and given that many countries are adding preformed VA to processed products, population biomarkers diagnosing hypervitaminosis before toxicity are urgently needed."
Doublecapricorn has reacted to this post.
Quote from Guest on November 27, 2018, 2:38 pm
Very interesting study Harry thanks for posting.
Very interesting study Harry thanks for posting.
Quote from Guest on November 27, 2018, 6:07 pm
I'm assuming that the "collected at time of death" aspect of the study is just a incidental detail?
liver vitamin A reserves collected from US adults at time of death
I'm assuming that the "collected at time of death" aspect of the study is just a incidental detail?
liver vitamin A reserves collected from US adults at time of death
Quote from Guest on November 27, 2018, 6:07 pm
I'm assuming that the "collected at time of death" aspect of the study is just a incidental detail?
liver vitamin A reserves collected from US adults at time of death
I don't know if it's incidental or not. It's entirely possible that the fact someone was dead would change the composition of their blood! The important point is that they found hypervitaminosis A in many of the cadavers by measuring their total liver reserves, which they say is the "gold standard" for making this diagnosis. I presume that this is less likely to change upon death.
Serum vitamin A has been shown to be a very unreliable measure of liver vitamin A status, except when there is an extreme "deficiency", so it's interesting to consider other ways that we might be able to find out what is going on, without having a liver biopsy. Unfortunately, tests for serum retinyl esters don't seems to be publicly available.
Quote from Guest on November 27, 2018, 6:07 pm
I'm assuming that the "collected at time of death" aspect of the study is just a incidental detail?
liver vitamin A reserves collected from US adults at time of death
I don't know if it's incidental or not. It's entirely possible that the fact someone was dead would change the composition of their blood! The important point is that they found hypervitaminosis A in many of the cadavers by measuring their total liver reserves, which they say is the "gold standard" for making this diagnosis. I presume that this is less likely to change upon death.
Serum vitamin A has been shown to be a very unreliable measure of liver vitamin A status, except when there is an extreme "deficiency", so it's interesting to consider other ways that we might be able to find out what is going on, without having a liver biopsy. Unfortunately, tests for serum retinyl esters don't seems to be publicly available.
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