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The interaction of dietary vitamin A and vitamin D
The abstract from the article titled "The interaction of dietary vitamin A and vitamin D related to skeletal development in the turkey poult" can be found below:
https://pubmed.ncbi.nlm.nih.gov/4009300/
Large white male turkey poults were fed diets with different levels of vitamins A and D to study the interaction of these vitamins with regard to skeletal development. Poults fed a basal diet deficient in both vitamins A and D developed severe lameness, growth depression, mortality and lesions consistent with rickets. Birds fed a diet containing the required level of vitamin D (900 ICU/kg, NRC estimated requirement) and a high level of vitamin A (400,000 IU/kg) also developed severe lameness, growth depression and a rachiticlike condition, characterized by thicker than normal proximal tibial epiphyseal plates and lower than normal bone mineral content. When fed a diet containing the required level of vitamin A (4,000 IU/kg, NRC estimated requirement) and a high level of vitamin D (900,000 ICU/kg), poults developed hypervitaminosis D as evidenced by mild growth depression and renal tubular mineralization. When poults were fed a diet containing high levels of both vitamins A and D growth rate and bone mineral content were similar to control poults fed a diet containing the required levels of vitamins A and D. In addition, lameness and renal tubular mineralization were not apparent in the poults fed a diet containing high levels of both vitamins A and D. It was concluded that there is an antagonistic interaction between vitamins A and D.
Basically, the paper says that vitamin A toxicity doesn't develop when vitamin D intake in also high. In turkey poults at least lol
I'm wondering how many people here are really vitamin D deficient and fighting an uphill battle using low A diets that don't yeild positive results by themselves alone. My first severe symptoms of vitamin A toxicity began when I started eating lots of retinol and carotene-containing foods while being deficient in vitamin D. Now that my vitamin A levels are at 60 ng/mL (150 nmol/L) after supplementing 30-50k IU a week in total, I can eat cheese on a daily basis. I do that to ensure I'm getting enough of K2. And I kinda like good cheese. Magnesium supplementation is required as well:
https://pubmed.ncbi.nlm.nih.gov/28471760/
Mg is essential in the metabolism of vitamin D, and taking large doses of vitamin D can induce severe depletion of Mg. Adequate magnesium supplementation should be considered as an important aspect of vitamin D therapy.
Grant gets sunlight and so it's been part of his success..
I've always done a bit of sunbathing, mixed with covering up too. Maybe that's why I'm not dead yet. Hubs has said he thinks he can tell when I get low vitamin D.
Of course, they aren't really talking about sunshine in this study? But that is where my mind goes because I'm not going to take supps. I guess there are vitamin D foods, although you are right, many here might be avoiding those, such as eggs. And as you say, k2 foods like cheese are probably also smart.
One interesting factoid for you is that I know someone who I think was VA toxic... and during young adulthood went on a tanning binge... which led to a case of the type of lupus that affects the skin...And I agree with this anecdote.. VA toxicity and sunlight can be a bad combo and can result in rashes. I think you have to be careful. I wouldn't be surprised if sunlight denatures VA in the skin. Which is maybe good over time, a bit of incremental prevention...but you don't want to go overboard.
I've also known life-long sunbathers who do seem healthy. And yet they also do seem to have skin aging and discoloration. But maybe it's worth it!
I once read that autoimmune issues are worse in the north.
When reading the above post, I also got to wondering how generally bad (?) the deficient diets were, as is often the case.
Quote from lil chick on February 28, 2024, 12:56 pmGrant gets sunlight and so it's been part of his success..
I've always done a bit of sunbathing, mixed with covering up too. Maybe that's why I'm not dead yet. Hubs has said he thinks he can tell when I get low vitamin D.
Of course, they aren't really talking about sunshine in this study? But that is where my mind goes because I'm not going to take supps. I guess there are vitamin D foods, although you are right, many here might be avoiding those, such as eggs. And as you say, k2 foods like cheese are probably also smart.
One interesting factoid for you is that I know someone who I think was VA toxic... and during young adulthood went on a tanning binge... which led to a case of the type of lupus that affects the skin...And I agree with this anecdote.. VA toxicity and sunlight can be a bad combo and can result in rashes. I think you have to be careful. I wouldn't be surprised if sunlight denatures VA in the skin. Which is maybe good over time, a bit of incremental prevention...but you don't want to go overboard.
I've also known life-long sunbathers who do seem healthy. And yet they also do seem to have skin aging and discoloration. But maybe it's worth it!
I once read that autoimmune issues are worse in the north.
When reading the above post, I also got to wondering how generally bad (?) the deficient diets were, as is often the case.
Getting the required daily amount of vitamin D from foods is nearly impossible, unless you start eating huge amounts of wild fish, which will sooner cause heavy metal poisoning than have any meaningful impact on one's vitamin D status. I had been eating quite a lot of eggs and canned cod liver (not the oil but the whole fatty liver spread on sandwiches) before testing as being extremely low in vitamin D. Maybe it was also the insanely high retinol content of the cod liver that got my vitamin D levels down and caused vitamin A toxicity along the way, but I later learned I have several mutations that affect vitamin D status and need pretty high doses of supplemental D3 to keep my levels within a healthy range. Getting sun exposure in the summer and taking around 2k IU of D3 daily is barely enough to get me beyond the lower limit. My blood beta-carotene level is finally down to low-normal after testing high on several occasions despite having an almost zero carotene diet for two years prior. The only major change has been vitamin D3 supplementation. My retinol levels always tested within range.
Sunbathing has been proven to have benefial effects other than for the vitamin D synthesis, but as you said it does make one's skin look older when done on a regular basis. My acquaintance from India once said they are all using sunscreen (young women in particular).
I also experience low magnesium symptoms when I take 50IU weekly - those are expectedly resolved after popping a mag pill but when taken in large doses magnesium tends to cause me low cortisol symptoms and drowsiness even the morning after. It's not a huge issue but I plan on reducing my weekly dose of D3 to 20-30k IU now that I've confirmed my levels are good.
I honesly believe there's too little talk on this forum about the need to have adequate levels of vitamin D to counteract vitamin A toxicity despite the fact that there's been numerous articles, studies and anecdotal accounts confirming it.
I wanted to quote this page as well:
https://drgominak.com/vitamin-d/
Even though every vitamin D supplement bottle will have a “recommended” dose, it is impossible to know how much vitamin D you should be taking without seeing how your body responds to dosing, and how much D it takes to increase your vitamin D blood level.
An example from my neurology practice, where I first discovered how each of us responds uniquely to vitamin D dosing:
A mother is dosing three of her kids with 2,000 IU/day for one month in the winter, Nathan goes from 20 ng/ml to 50 ng/ml, Samantha goes from 18ng/ml to 25ng/ml and Alex goes from 25ng/ml to 95 ng/ml. Each was taking exactly the same dose for the same period of time!
So saying something along the lines "I get plenty of sunlight and/or take X amount of D3 in supplements, so I definitely get enough of it" is wishful thinking. You may have adequate levels, or you may still be deficient or even toxic - you never really know without testing. I've read accounts from construction workers (!) in Australia (!) who were vitamin D deficient, and my friends' friend tested at 130 ng/mL (marked as ++ for very high) after taking 15K IU daily for a month. It's a very large dose, for sure, but many people take almost that much for longer periods of time and don't get nearly to such high a level.
I don't think trying to resolve vitamin A toxicity without knowing one's vitamin D level can have a noticeable effect.
For the record: I don't push any supplements or tests, and I don't buy into the popular idea among some vit D advocates that reaching a blood level of 100 ng is essential and will resolve all health woes. I think most people will do just fine having half that. Also, I don't know whether correcting one's vitamin D status will automatically flush any excess vitamin A from the liver. There are some positive accounts on Ray Peat's forum but I personally do better when I make sure to eat enough fiber and not to overdo it with retinol or carotene, which means I'm going to wait for a bit before trying small amounts of liver or a carrot again (or I may just forgo the liver altogether and be happy with it).
What really pushed me to try supplementing high doses of D3 were some posts here and on Ray Peat's forum and some others saying something to the effect of "I've been on a low A diet for 2-3-4-5 or more years, I generally feel good as long as I avoid all high-retinol or carotene foods... my sensitivity for vit A is still high but I hope one day I will fully recover". I don't mean to offend anyone, but it's ridiculous. If you feel like complete crap once you have a meal with any substantial amount of vit A after several months of years of eating low A, there's something wrong with how your body works, which can be caused by a number of deficiencies. I just got tired of being like that.
Quote from Viktor on February 29, 2024, 4:22 amQuote from lil chick on February 28, 2024, 12:56 pmGrant gets sunlight and so it's been part of his success..
I've always done a bit of sunbathing, mixed with covering up too. Maybe that's why I'm not dead yet. Hubs has said he thinks he can tell when I get low vitamin D.
Of course, they aren't really talking about sunshine in this study? But that is where my mind goes because I'm not going to take supps. I guess there are vitamin D foods, although you are right, many here might be avoiding those, such as eggs. And as you say, k2 foods like cheese are probably also smart.
One interesting factoid for you is that I know someone who I think was VA toxic... and during young adulthood went on a tanning binge... which led to a case of the type of lupus that affects the skin...And I agree with this anecdote.. VA toxicity and sunlight can be a bad combo and can result in rashes. I think you have to be careful. I wouldn't be surprised if sunlight denatures VA in the skin. Which is maybe good over time, a bit of incremental prevention...but you don't want to go overboard.
I've also known life-long sunbathers who do seem healthy. And yet they also do seem to have skin aging and discoloration. But maybe it's worth it!
I once read that autoimmune issues are worse in the north.
When reading the above post, I also got to wondering how generally bad (?) the deficient diets were, as is often the case.
Getting the required daily amount of vitamin D from foods is nearly impossible, unless you start eating huge amounts of wild fish, which will sooner cause heavy metal poisoning than have any meaningful impact on one's vitamin D status. I had been eating quite a lot of eggs and canned cod liver (not the oil but the whole fatty liver spread on sandwiches) before testing as being extremely low in vitamin D. Maybe it was also the insanely high retinol content of the cod liver that got my vitamin D levels down and caused vitamin A toxicity along the way, but I later learned I have several mutations that affect vitamin D status and need pretty high doses of supplemental D3 to keep my levels within a healthy range. Getting sun exposure in the summer and taking around 2k IU of D3 daily is barely enough to get me beyond the lower limit. My blood beta-carotene level is finally down to low-normal after testing high on several occasions despite having an almost zero carotene diet for two years prior. The only major change has been vitamin D3 supplementation. My retinol levels always tested within range.
Sunbathing has been proven to have benefial effects other than for the vitamin D synthesis, but as you said it does make one's skin look older when done on a regular basis. My acquaintance from India once said they are all using sunscreen (young women in particular).
I also experience low magnesium symptoms when I take 50IU weekly - those are expectedly resolved after popping a mag pill but when taken in large doses magnesium tends to cause me low cortisol symptoms and drowsiness even the morning after. It's not a huge issue but I plan on reducing my weekly dose of D3 to 20-30k IU now that I've confirmed my levels are good.
I honesly believe there's too little talk on this forum about the need to have adequate levels of vitamin D to counteract vitamin A toxicity despite the fact that there's been numerous articles, studies and anecdotal accounts confirming it.
I wanted to quote this page as well:
https://drgominak.com/vitamin-d/
Even though every vitamin D supplement bottle will have a “recommended” dose, it is impossible to know how much vitamin D you should be taking without seeing how your body responds to dosing, and how much D it takes to increase your vitamin D blood level.
An example from my neurology practice, where I first discovered how each of us responds uniquely to vitamin D dosing:
A mother is dosing three of her kids with 2,000 IU/day for one month in the winter, Nathan goes from 20 ng/ml to 50 ng/ml, Samantha goes from 18ng/ml to 25ng/ml and Alex goes from 25ng/ml to 95 ng/ml. Each was taking exactly the same dose for the same period of time!
So saying something along the lines "I get plenty of sunlight and/or take X amount of D3 in supplements, so I definitely get enough of it" is wishful thinking. You may have adequate levels, or you may still be deficient or even toxic - you never really know without testing. I've read accounts from construction workers (!) in Australia (!) who were vitamin D deficient, and my friends' friend tested at 130 ng/mL (marked as ++ for very high) after taking 15K IU daily for a month. It's a very large dose, for sure, but many people take almost that much for longer periods of time and don't get nearly to such high a level.
I don't think trying to resolve vitamin A toxicity without knowing one's vitamin D level can have a noticeable effect.
For the record: I don't push any supplements or tests, and I don't buy into the popular idea among some vit D advocates that reaching a blood level of 100 ng is essential and will resolve all health woes. I think most people will do just fine having half that. Also, I don't know whether correcting one's vitamin D status will automatically flush any excess vitamin A from the liver. There are some positive accounts on Ray Peat's forum but I personally do better when I make sure to eat enough fiber and not to overdo it with retinol or carotene, which means I'm going to wait for a bit before trying small amounts of liver or a carrot again (or I may just forgo the liver altogether and be happy with it).
What really pushed me to try supplementing high doses of D3 were some posts here and on Ray Peat's forum and some others saying something to the effect of "I've been on a low A diet for 2-3-4-5 or more years, I generally feel good as long as I avoid all high-retinol or carotene foods... my sensitivity for vit A is still high but I hope one day I will fully recover". I don't mean to offend anyone, but it's ridiculous. If you feel like complete crap once you have a meal with any substantial amount of vit A after several months of years of eating low A, there's something wrong with how your body works, which can be caused by a number of deficiencies. I just got tired of being like that.
25D ranges are largely arbitrary but can indicate illness. D3 is immunosuppressive so it can alleviate symptoms temporarily. Did you get the 1,25D test before supplementation? Otherwise, we don't really know if one is deficient.
Quote from Armin on February 29, 2024, 6:56 amQuote from Viktor on February 29, 2024, 4:22 amQuote from lil chick on February 28, 2024, 12:56 pmGrant gets sunlight and so it's been part of his success..
I've always done a bit of sunbathing, mixed with covering up too. Maybe that's why I'm not dead yet. Hubs has said he thinks he can tell when I get low vitamin D.
Of course, they aren't really talking about sunshine in this study? But that is where my mind goes because I'm not going to take supps. I guess there are vitamin D foods, although you are right, many here might be avoiding those, such as eggs. And as you say, k2 foods like cheese are probably also smart.
One interesting factoid for you is that I know someone who I think was VA toxic... and during young adulthood went on a tanning binge... which led to a case of the type of lupus that affects the skin...And I agree with this anecdote.. VA toxicity and sunlight can be a bad combo and can result in rashes. I think you have to be careful. I wouldn't be surprised if sunlight denatures VA in the skin. Which is maybe good over time, a bit of incremental prevention...but you don't want to go overboard.
I've also known life-long sunbathers who do seem healthy. And yet they also do seem to have skin aging and discoloration. But maybe it's worth it!
I once read that autoimmune issues are worse in the north.
When reading the above post, I also got to wondering how generally bad (?) the deficient diets were, as is often the case.
Getting the required daily amount of vitamin D from foods is nearly impossible, unless you start eating huge amounts of wild fish, which will sooner cause heavy metal poisoning than have any meaningful impact on one's vitamin D status. I had been eating quite a lot of eggs and canned cod liver (not the oil but the whole fatty liver spread on sandwiches) before testing as being extremely low in vitamin D. Maybe it was also the insanely high retinol content of the cod liver that got my vitamin D levels down and caused vitamin A toxicity along the way, but I later learned I have several mutations that affect vitamin D status and need pretty high doses of supplemental D3 to keep my levels within a healthy range. Getting sun exposure in the summer and taking around 2k IU of D3 daily is barely enough to get me beyond the lower limit. My blood beta-carotene level is finally down to low-normal after testing high on several occasions despite having an almost zero carotene diet for two years prior. The only major change has been vitamin D3 supplementation. My retinol levels always tested within range.
Sunbathing has been proven to have benefial effects other than for the vitamin D synthesis, but as you said it does make one's skin look older when done on a regular basis. My acquaintance from India once said they are all using sunscreen (young women in particular).
I also experience low magnesium symptoms when I take 50IU weekly - those are expectedly resolved after popping a mag pill but when taken in large doses magnesium tends to cause me low cortisol symptoms and drowsiness even the morning after. It's not a huge issue but I plan on reducing my weekly dose of D3 to 20-30k IU now that I've confirmed my levels are good.
I honesly believe there's too little talk on this forum about the need to have adequate levels of vitamin D to counteract vitamin A toxicity despite the fact that there's been numerous articles, studies and anecdotal accounts confirming it.
I wanted to quote this page as well:
https://drgominak.com/vitamin-d/
Even though every vitamin D supplement bottle will have a “recommended” dose, it is impossible to know how much vitamin D you should be taking without seeing how your body responds to dosing, and how much D it takes to increase your vitamin D blood level.
An example from my neurology practice, where I first discovered how each of us responds uniquely to vitamin D dosing:
A mother is dosing three of her kids with 2,000 IU/day for one month in the winter, Nathan goes from 20 ng/ml to 50 ng/ml, Samantha goes from 18ng/ml to 25ng/ml and Alex goes from 25ng/ml to 95 ng/ml. Each was taking exactly the same dose for the same period of time!
So saying something along the lines "I get plenty of sunlight and/or take X amount of D3 in supplements, so I definitely get enough of it" is wishful thinking. You may have adequate levels, or you may still be deficient or even toxic - you never really know without testing. I've read accounts from construction workers (!) in Australia (!) who were vitamin D deficient, and my friends' friend tested at 130 ng/mL (marked as ++ for very high) after taking 15K IU daily for a month. It's a very large dose, for sure, but many people take almost that much for longer periods of time and don't get nearly to such high a level.
I don't think trying to resolve vitamin A toxicity without knowing one's vitamin D level can have a noticeable effect.
For the record: I don't push any supplements or tests, and I don't buy into the popular idea among some vit D advocates that reaching a blood level of 100 ng is essential and will resolve all health woes. I think most people will do just fine having half that. Also, I don't know whether correcting one's vitamin D status will automatically flush any excess vitamin A from the liver. There are some positive accounts on Ray Peat's forum but I personally do better when I make sure to eat enough fiber and not to overdo it with retinol or carotene, which means I'm going to wait for a bit before trying small amounts of liver or a carrot again (or I may just forgo the liver altogether and be happy with it).
What really pushed me to try supplementing high doses of D3 were some posts here and on Ray Peat's forum and some others saying something to the effect of "I've been on a low A diet for 2-3-4-5 or more years, I generally feel good as long as I avoid all high-retinol or carotene foods... my sensitivity for vit A is still high but I hope one day I will fully recover". I don't mean to offend anyone, but it's ridiculous. If you feel like complete crap once you have a meal with any substantial amount of vit A after several months of years of eating low A, there's something wrong with how your body works, which can be caused by a number of deficiencies. I just got tired of being like that.
25D ranges are largely arbitrary but can indicate illness. D3 is immunosuppressive so it can alleviate symptoms temporarily. Did you get the 1,25D test before supplementation? Otherwise, we don't really know if one is deficient.
No. This article
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665033/
says that Serum 1,25(OH)2D provides no information about vitamin D status and is often normal or even elevated due to secondary hyperparathyroidism associated with vitamin D deficiency
and that only 25(OH)D is used to assess one's vitamin D status. No doctor ever, not even the naturopathic ones or really experienced endocrinologists, suggested I should test 1,25D but all recommended checking my 25(OH)D levels.
Quote from Viktor on February 29, 2024, 9:55 amQuote from Armin on February 29, 2024, 6:56 amQuote from Viktor on February 29, 2024, 4:22 amQuote from lil chick on February 28, 2024, 12:56 pmGrant gets sunlight and so it's been part of his success..
I've always done a bit of sunbathing, mixed with covering up too. Maybe that's why I'm not dead yet. Hubs has said he thinks he can tell when I get low vitamin D.
Of course, they aren't really talking about sunshine in this study? But that is where my mind goes because I'm not going to take supps. I guess there are vitamin D foods, although you are right, many here might be avoiding those, such as eggs. And as you say, k2 foods like cheese are probably also smart.
One interesting factoid for you is that I know someone who I think was VA toxic... and during young adulthood went on a tanning binge... which led to a case of the type of lupus that affects the skin...And I agree with this anecdote.. VA toxicity and sunlight can be a bad combo and can result in rashes. I think you have to be careful. I wouldn't be surprised if sunlight denatures VA in the skin. Which is maybe good over time, a bit of incremental prevention...but you don't want to go overboard.
I've also known life-long sunbathers who do seem healthy. And yet they also do seem to have skin aging and discoloration. But maybe it's worth it!
I once read that autoimmune issues are worse in the north.
When reading the above post, I also got to wondering how generally bad (?) the deficient diets were, as is often the case.
Getting the required daily amount of vitamin D from foods is nearly impossible, unless you start eating huge amounts of wild fish, which will sooner cause heavy metal poisoning than have any meaningful impact on one's vitamin D status. I had been eating quite a lot of eggs and canned cod liver (not the oil but the whole fatty liver spread on sandwiches) before testing as being extremely low in vitamin D. Maybe it was also the insanely high retinol content of the cod liver that got my vitamin D levels down and caused vitamin A toxicity along the way, but I later learned I have several mutations that affect vitamin D status and need pretty high doses of supplemental D3 to keep my levels within a healthy range. Getting sun exposure in the summer and taking around 2k IU of D3 daily is barely enough to get me beyond the lower limit. My blood beta-carotene level is finally down to low-normal after testing high on several occasions despite having an almost zero carotene diet for two years prior. The only major change has been vitamin D3 supplementation. My retinol levels always tested within range.
Sunbathing has been proven to have benefial effects other than for the vitamin D synthesis, but as you said it does make one's skin look older when done on a regular basis. My acquaintance from India once said they are all using sunscreen (young women in particular).
I also experience low magnesium symptoms when I take 50IU weekly - those are expectedly resolved after popping a mag pill but when taken in large doses magnesium tends to cause me low cortisol symptoms and drowsiness even the morning after. It's not a huge issue but I plan on reducing my weekly dose of D3 to 20-30k IU now that I've confirmed my levels are good.
I honesly believe there's too little talk on this forum about the need to have adequate levels of vitamin D to counteract vitamin A toxicity despite the fact that there's been numerous articles, studies and anecdotal accounts confirming it.
I wanted to quote this page as well:
https://drgominak.com/vitamin-d/
Even though every vitamin D supplement bottle will have a “recommended” dose, it is impossible to know how much vitamin D you should be taking without seeing how your body responds to dosing, and how much D it takes to increase your vitamin D blood level.
An example from my neurology practice, where I first discovered how each of us responds uniquely to vitamin D dosing:
A mother is dosing three of her kids with 2,000 IU/day for one month in the winter, Nathan goes from 20 ng/ml to 50 ng/ml, Samantha goes from 18ng/ml to 25ng/ml and Alex goes from 25ng/ml to 95 ng/ml. Each was taking exactly the same dose for the same period of time!
So saying something along the lines "I get plenty of sunlight and/or take X amount of D3 in supplements, so I definitely get enough of it" is wishful thinking. You may have adequate levels, or you may still be deficient or even toxic - you never really know without testing. I've read accounts from construction workers (!) in Australia (!) who were vitamin D deficient, and my friends' friend tested at 130 ng/mL (marked as ++ for very high) after taking 15K IU daily for a month. It's a very large dose, for sure, but many people take almost that much for longer periods of time and don't get nearly to such high a level.
I don't think trying to resolve vitamin A toxicity without knowing one's vitamin D level can have a noticeable effect.
For the record: I don't push any supplements or tests, and I don't buy into the popular idea among some vit D advocates that reaching a blood level of 100 ng is essential and will resolve all health woes. I think most people will do just fine having half that. Also, I don't know whether correcting one's vitamin D status will automatically flush any excess vitamin A from the liver. There are some positive accounts on Ray Peat's forum but I personally do better when I make sure to eat enough fiber and not to overdo it with retinol or carotene, which means I'm going to wait for a bit before trying small amounts of liver or a carrot again (or I may just forgo the liver altogether and be happy with it).
What really pushed me to try supplementing high doses of D3 were some posts here and on Ray Peat's forum and some others saying something to the effect of "I've been on a low A diet for 2-3-4-5 or more years, I generally feel good as long as I avoid all high-retinol or carotene foods... my sensitivity for vit A is still high but I hope one day I will fully recover". I don't mean to offend anyone, but it's ridiculous. If you feel like complete crap once you have a meal with any substantial amount of vit A after several months of years of eating low A, there's something wrong with how your body works, which can be caused by a number of deficiencies. I just got tired of being like that.
25D ranges are largely arbitrary but can indicate illness. D3 is immunosuppressive so it can alleviate symptoms temporarily. Did you get the 1,25D test before supplementation? Otherwise, we don't really know if one is deficient.
No. This article
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665033/
says that Serum 1,25(OH)2D provides no information about vitamin D status and is often normal or even elevated due to secondary hyperparathyroidism associated with vitamin D deficiency
and that only 25(OH)D is used to assess one's vitamin D status. No doctor ever, not even the naturopathic ones or really experienced endocrinologists, suggested I should test 1,25D but all recommended checking my 25(OH)D levels.
Sad state of healthcare where we look at the inactive form and not the active form. The fact that the active form is in range destroys the idea that deficiency is a real thing.
Regarding sunlight generated vitamin D and Vitamin A toxicity: I have been titrating noon-day UVB for the last year and a half in Florida and just got wind of the vitamin A protocol. While I've been eating liver and yolks every day the past year I've not had any outward symptoms of A toxicity...Interesting. Not saying it's not working it's bad deeds under the surface but for now no outward obvious symptoms. (I stopped eating liver and eggs last month when I read Grants article) Also, my D levels on the last measurement were 103 from the sun alone. We are very careful with the dosage of sunlight...only 20 minutes total averaging every other day at solar noon, covering the face.
Also of note, contrary to conventional thinking after a year of this exposure my skin has not been negatively effected. It looks better than ever. I have a feeling that the key here is being very strict about noon exposure. 9-10 minutes lying on back and 9-10 minutes lying on front. The other piece...my wife and I feel amazing in terms of energy and reslilance to colds and flu...none during the time we started sun exposure. As soon as we started the sun program we stopped oral D supplementation as well.
Yes, I have often sunbathed similarly to Steve above, and will start soon. It helps to have a place to do this set up so that you don't make excuses LOL. I am so light as to just be called "clear" haha. I sunbathe for an even shorter time. Then I mostly cover up. But now I'm not as dedicated to covering as I used to be. I haven't used sunscreen for many years. My family totes umbrellas to the beach.
It really helps me to do this in advance of any vacation. Starting this regimen can stir things up.
I wonder if he had the same inspiration, which was a book called "Naked at Noon".
I don't really cover the face, although I do put an arm across my eyes.
When calcidiol levels are low, calcitriol levels are often elevated and VDR receptor resistance is often present. Some of the possible causes of VDR receptor resistance are pathogens, mold exposure, heavy metals, insulin resistance and Hypervitaminosis A.
Aflatoxin B1 (AFB1), produced by fungi of the genus Aspergillus, is the most toxic and carcinogenic mycotoxin among the classes of aflatoxins. Previous research showed that AFB1 affects vitamin D receptor (VDR) expression. In the present study, integrated computational and experimental studies were carried out to investigate how AFB1 can interfere with Vitamin D signalling. A competitive antagonism of AFB1 toward RXRα and VDR was hypothesized by comparing the docked complex of AFB1/RXRα and AFB1/VDR ligand-binding domain (LBD) with the X-ray structures of RXRα and VDR bound to known ligands. Accordingly, we demonstrated that AFB1 can affect vitamin D-mediated transcriptional activation of VDR by impairing the formation of protein complexes containing both VDR-RXRα and RXRα/RAR and affecting the subcellular localization of VDR and RXRα. As a whole, our data indicate that AFB1 can interfere with different molecular pathways triggered by vitamin D with an antagonistic mechanism of action.
Aspergillus versicolor is a slow-growing species of filamentous fungus commonly found in damp indoor environments and on food products.[1][2] It has a characteristic musty odor associated with moldy homes and is a major producer of the hepatotoxic and carcinogenic mycotoxin sterigmatocystin.[3][4] Like other Aspergillus species, A. versicolor is an eye, nose, and throat irritant.
Aspergillus versicolor is a highly ubiquitous species commonly isolated from soil, plant debris, marine environments, and indoor air environments.[5][6] It is among the most common of indoor molds, often reported in dust and in water-damaged building materials, such as wallboards, insulation, textiles, ceiling tiles, and manufactured wood.[7][8]
Sterigmatocystin is a toxic metabolite structurally closely related to the aflatoxins as it is the penultimate precursor of aflatoxins B1 and G1.