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The Interferon / Retinoic Acid connection
Interferon therapy is known to cause autoimmune conditions:
Risk of autoimmune complications associated with Interferon therapy
Retinoic acid and interferon seem to have a close relationship:
Retinoic acid and interferon signaling cross talk in normal and RA-resistant APL cells - "RA induces IFN-a synthesis"
I thought this was significant. Can anyone with a better understanding of biochemistry extrapolate from this?
Here's more
The astonishing functional overlap of changes in FoxO-mediated gene transcription and isotretinoin mediated gene transcription (Table 1) strongly suggests that isotretinoin and its isomerization product ATRA induces upregulation of FoxO-signaling and exerts apoptotic effects in multiple cell types like the muscle, the bone and the brain.
[...]
In fact, all isotretinoin-mediated effects on sebocyte apoptosis, sebaceous lipogenesis, anti-inflammatory activity, downregulation of ROS can be explained by upregulation of nuclear levels of FoxO transcription factors. All isotretinoin-induced adverse effect on hepatic glucose and lipid metabolism, retinoid-induced dyslipoproteinemia, loss of bone density, myotoxic effects, mucocutaneous side effects, adverse psychiatric effects, chemopreventive effects and isotretinoin's teratogenicity appear to result from a common mechanism, i.e., FoxO-mediated changes of gene expression.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219165/
That’s just great that they are finally figuring the mechanisms and wide ranging scope of destruction caused by isotretinoin. But, isn’t isotretinoin (retinoic acid) the so-called “active form of vitamin A”. So, what am I missing here?