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Vit A, Aromatase, Estrogen and Copper

#11 · July 19, 2021, 4:15 am

Quote from tim on August 17, 2020, 6:15 pm

This article contradicts the negative perspective on dairy above. It shows that estrogen levels are similar in meat, eggs and dairy. Oddly boar is very high in estrogen.

I wonder if vA plays a role in children reaching puberty younger? I've seen discussion about carbohydrate rich diets causing younger puberty, I guess that could be caused by insulin increasing aromatase as well. Would it be logical to conclude that moderate carbohydrate, lower vA diets might prevent early puberty?

I do not load the link. But I would like to note that there is also a question of the bioavailability of hormones. Therefore, a simple measurement does not mean much, and I would trust the first article more.

#12 · July 19, 2021, 5:01 am

Quote from rockarolla on July 19, 2021, 5:01 am
Thanks for the topic, tim. Here is some extra info:

Cow’s milk as a dietary source of equol[phytoestrogen] and phenolic antioxidants: differential distribution in the milk aqueous and lipid fractions
https://link.springer.com/article/10.1007/s13594-014-0183-4
Cow’s milk contains bioactive secondary phenolic compounds that are formed by bovine’s gut bacterial flora from plant phenolic compounds. Equol, a metabolite of daidzein, is one such secondary compounds of biological interest. The potential of phenolic compounds in milk as dietary antioxidants and their distribution within the milk matrix were examined. The equol concentrations, total phenolic contents, and antioxidant activity (Trolox equivalent antioxidant capacity and inhibition of F2-isoprostanes formation by human neutrophils in vitro) were measured and compared in commercial cow’s milk of varying lipid contents. The Trolox equivalent antioxidant capacity and ability to inhibit F2-isoprostanes formation in vitro increased with the concentrations of phenolic compounds and equol in the milk. Equol and total phenolic compound concentrations correlated positively with the milk lipid concentrations. Separate experiments using homogenized and non-homogenized milk showed that dairy equol and phenolic compounds distributed to larger extent in the lipid fraction than in the aqueous fraction of cow’s milk. Our results showed that cow’s milk may serve as a dietary source of unique phenolic compounds, such as equol. Skimming of cow’s milk may reduce the original amount of equol and phenolic compounds and thereby diminishes the overall nutritive value and functional properties of cow’s milk.

Dairy consumption is a significant correlate of urinary equol[phytoestrogen] concentration in a representative sample of US adults
https://academic.oup.com/ajcn/article/93/5/1109/4597823

Background: Equol and O-desmethylangolensin (ODMA) are products of gut bacterial metabolism of daidzein, a phytochemical found predominantly in soy. Dietary sources of equol from animal products have been identified, which has raised the question of the relative contributions of daidzein intake and gut metabolism to equol and of equol intake from animal products in low-soy-consuming populations.

Objective: The objective was to evaluate the contribution of dietary food groups to urinary isoflavone and daidzein metabolite concentrations in a representative sample of US adults.

Design: A cross-sectional analysis of dietary and urinary isoflavonoid data from 3115 individuals in the 2001–2002 and 2003–2004 data cycles of the National Nutrition and Health Examination Survey (NHANES) was conducted.

Results: Daidzein intake and consumption frequency of grain products and legumes, nuts, and seeds were significant correlates of daidzein, genistein, and ODMA concentrations; and soy legumes were a stronger correlate than were nonsoy legumes. Milk and milk product consumption and daidzein intake, but not legumes, were significant correlates of urinary equol concentrations; milk products were more strongly correlated (P for trend < 0.001) than was daidzein intake (P = 0.011).

Conclusions: These results suggest that dietary daidzein and legumes may contribute to urinary daidzein, genistein, and ODMA concentrations in this low-soy-consuming population. These results also suggest that equol concentrations in low-soy-consuming populations may reflect equol intakes from mammalian milk sources and may not reflect the endogenous production of equol from the microbial metabolism of daidzein—an observation not yet documented in the US population.

Thanks for the topic, tim. Here is some extra info:

Cow’s milk as a dietary source of equol[phytoestrogen] and phenolic antioxidants: differential distribution in the milk aqueous and lipid fractions
https://link.springer.com/article/10.1007/s13594-014-0183-4
Cow’s milk contains bioactive secondary phenolic compounds that are formed by bovine’s gut bacterial flora from plant phenolic compounds. Equol, a metabolite of daidzein, is one such secondary compounds of biological interest. The potential of phenolic compounds in milk as dietary antioxidants and their distribution within the milk matrix were examined. The equol concentrations, total phenolic contents, and antioxidant activity (Trolox equivalent antioxidant capacity and inhibition of F2-isoprostanes formation by human neutrophils in vitro) were measured and compared in commercial cow’s milk of varying lipid contents. The Trolox equivalent antioxidant capacity and ability to inhibit F2-isoprostanes formation in vitro increased with the concentrations of phenolic compounds and equol in the milk. Equol and total phenolic compound concentrations correlated positively with the milk lipid concentrations. Separate experiments using homogenized and non-homogenized milk showed that dairy equol and phenolic compounds distributed to larger extent in the lipid fraction than in the aqueous fraction of cow’s milk. Our results showed that cow’s milk may serve as a dietary source of unique phenolic compounds, such as equol. Skimming of cow’s milk may reduce the original amount of equol and phenolic compounds and thereby diminishes the overall nutritive value and functional properties of cow’s milk.

Dairy consumption is a significant correlate of urinary equol[phytoestrogen] concentration in a representative sample of US adults
https://academic.oup.com/ajcn/article/93/5/1109/4597823

Background: Equol and O-desmethylangolensin (ODMA) are products of gut bacterial metabolism of daidzein, a phytochemical found predominantly in soy. Dietary sources of equol from animal products have been identified, which has raised the question of the relative contributions of daidzein intake and gut metabolism to equol and of equol intake from animal products in low-soy-consuming populations.

Objective: The objective was to evaluate the contribution of dietary food groups to urinary isoflavone and daidzein metabolite concentrations in a representative sample of US adults.

Design: A cross-sectional analysis of dietary and urinary isoflavonoid data from 3115 individuals in the 2001–2002 and 2003–2004 data cycles of the National Nutrition and Health Examination Survey (NHANES) was conducted.

Results: Daidzein intake and consumption frequency of grain products and legumes, nuts, and seeds were significant correlates of daidzein, genistein, and ODMA concentrations; and soy legumes were a stronger correlate than were nonsoy legumes. Milk and milk product consumption and daidzein intake, but not legumes, were significant correlates of urinary equol concentrations; milk products were more strongly correlated (P for trend < 0.001) than was daidzein intake (P = 0.011).

Conclusions: These results suggest that dietary daidzein and legumes may contribute to urinary daidzein, genistein, and ODMA concentrations in this low-soy-consuming population. These results also suggest that equol concentrations in low-soy-consuming populations may reflect equol intakes from mammalian milk sources and may not reflect the endogenous production of equol from the microbial metabolism of daidzein—an observation not yet documented in the US population.

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#13 · July 19, 2021, 5:18 am

Another potential problem with dairy is that its consumption is correlated with raised levels(overexpression) of adiponectin(protein hormone). Adiponectin negatively regulates TNF-alpha levels like almost every pharma masking-the-disease drug does, which could be potentially problematic on a long run for a relatively healthy person. The modulation could come from A, lactoferrin, specific dairy proteins, but probably A is the major contributor.

https://www.sciencedirect.com/science/article/abs/pii/S0939475320300442
• Dairy products intake could significantly reduce CRP levels.
• Dairy products intake could significantly decrease serum TNF-α and IL-6 concentrations.
• Dairy products intake could significantly increase serum adiponectin levels.

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Vit A, Aromatase, Estrogen and Copper

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