Quote from
bludicka on October 30, 2019, 5:56 am
https://www.traceelements.com/Docs/The%20Nutritional%20Relationships%20of%20Copper.pdf
"However, zinc, vitamin C, and vitamin A are mutually antagonistic to copper; if taken in excessively high dosages by individuals with a copper deficiency, they can actually promote infectious processes — especially those of bacterial origin."
"As an example, the need for vitamin A, C, B6, B3, and B5 is reduced in a copper-deficient state. Conversely, hypervitaminosis of most of these vitamins can be reduced by supplying adequate amounts of copper. We can see particularly that the adverse effects of hyper-vitaminosis A can be decreased by copper supplementation.
"Causes of vitamin A deficiency include inadequate intake, impaired absorption or storage, and poor conversion of carotene to active vitamin A. Poor absorption and/ or storage is associated with excessive alcohol intake, celiac disease, cystic fibrosis of the pancreas, ulcerative colitis, biliary obstruction, and cirrhosis of the liver."
"The different effects on bone metabolism also indicate vitamin A and D antagonism. Vitamin D increases the absorption and retention of calcium, while excess vitamin A causes bone resorption and decalcification"
"Being oil soluble, vitamin E may compete with vitamin A for absorption. Vitamin A is known to suppress vitamin E levels in immunopoietic tissue."
" Other vitamins having a potential to antagonize vitamin A include B1, B12, B6, and K. "
" The mineral zinc is intimately associated with vitamin A. Adequate amounts are required for the mobilization of vitamin A from the liver. In several experiments involving animal and human studies, vitamin A deficiency symptoms did not respond to vitamin A supplementation alone when a zinc deficiency co-existed. However symptoms of vitamin A deficiency, such as impaired night vision, improved only after zinc supplementation. Zinc is involved in maintaining the plasma retinal binding protein (RBP), a specific transporter for vitamin A."
" Iron deficiency anemia is associated with low vitamin A status as well as reduced hemoglobin levels.19 Vitamin A apparently facilitates the mobilization of stored iron for incorporation into erythrocytes."
" The conversion of carotene to vitamin A is influenced by thyroxine. Studies show that thyroidectomy or suppression of the thyroid produces hypercarotenemia and reduced retinol levels in the liver. It has been speculated that vitamin A deficiency is associated with hypothyroidism. Studies reveal that low vitamin A levels are associated with goiter formation."
" Tissue estrogen sensitivity is increased in the presence of vitamin A deficiency. The concentrations of RBP are lowest prior to the preovulatory peak in estradiol levels. According to the study reported by Keyvani, et al, females are affected by goiter more than males due to the fact that females have lower vitamin A levels."
" The adrenocortical hormones increase the mobilization of vitamin A from the liver. This effect has also been reported in the treatment of rheumatic children with cortisone. Adequate adrenal function is also necessary for the mobilization of vitamin A stores. It is possible that adrenal and thyroid insufficiency contributes to signs of vitamin A deficiency or increased requirements due to an inability to mobilize it from storage."
" Adequate protein is necessary for the mobilization of vitamin A from the liver to the blood stream. Vitamin A deficiency is associated with protein malnutrition. Normal serum vitamin A levels can be restored when protein is added to the diet, providing there are adequate liver reserves of the vitamin. However, if liver reserves of vitamin A are depleted, dietary protein may precipitate an acute vitamin A deficiency."
Vitamin A and copper:
These findings suggest that a copper-deficient diet may cause defective transport of vitamin A from liver to blood.
Vitamin A and zinc:
I think that the right balancing of nutrients can speed up VA detox and its release from liver to blood. And the deficiency of any of the key nutrients can slow down the detox and release of VA from the liver. And so it can be very individual how quickly the liver reserves of VA run out + factors as function of ADH and ALDH enzymes, some diseases, physical activity, function of thyroid, adrenal glands. Only rice and beef diet can be very successful in the first months, but as nutrients run out or some new imbalances start as the body gets rid of VA, progress stops or slows down.
This is form Grant's five years update:
" The other diet experiment I tried was adding Brazil nuts. In theory, these nuts should have been safe; providing zinc, selenium, vitamin E, etc. But, after about two weeks, I felt I was starting to have a bad reaction to them. Of course, that bad reaction could have been a complete coincidence too. But, stopping them also seemed to coincide with resolving the negative reaction too. The negative reaction was mostly just the development of dry skin on my outer earlobes. "
I wonder if the addition of copper in brasil nuts could cause the release of VA from the liver and worsening his symptoms.
Yesterday I read this:
This diet longterm is totall deficient in copper, veryl low in potassium, calcium, magnesium, molybdenum, vitamin E, K, folate and his progress is not steady:
"So my overall mood/energy/health went from a 1 (worst I’d ever felt) before I started the diet, to a 10 (feeling amazing, best I’d felt in over a decade) after about two or three months on the VAD diet, but then after a few months gradually down to a 7 ( feeling pretty good) after a couple more months, and that’s been my “summer baseline” since then because it went down to a 5-6 over the winter and back up when summer returned."
https://www.traceelements.com/Docs/The%20Nutritional%20Relationships%20of%20Copper.pdf
"However, zinc, vitamin C, and vitamin A are mutually antagonistic to copper; if taken in excessively high dosages by individuals with a copper deficiency, they can actually promote infectious processes — especially those of bacterial origin."
"As an example, the need for vitamin A, C, B6, B3, and B5 is reduced in a copper-deficient state. Conversely, hypervitaminosis of most of these vitamins can be reduced by supplying adequate amounts of copper. We can see particularly that the adverse effects of hyper-vitaminosis A can be decreased by copper supplementation.
"Causes of vitamin A deficiency include inadequate intake, impaired absorption or storage, and poor conversion of carotene to active vitamin A. Poor absorption and/ or storage is associated with excessive alcohol intake, celiac disease, cystic fibrosis of the pancreas, ulcerative colitis, biliary obstruction, and cirrhosis of the liver."
"The different effects on bone metabolism also indicate vitamin A and D antagonism. Vitamin D increases the absorption and retention of calcium, while excess vitamin A causes bone resorption and decalcification"
"Being oil soluble, vitamin E may compete with vitamin A for absorption. Vitamin A is known to suppress vitamin E levels in immunopoietic tissue."
" Other vitamins having a potential to antagonize vitamin A include B1, B12, B6, and K. "
" The mineral zinc is intimately associated with vitamin A. Adequate amounts are required for the mobilization of vitamin A from the liver. In several experiments involving animal and human studies, vitamin A deficiency symptoms did not respond to vitamin A supplementation alone when a zinc deficiency co-existed. However symptoms of vitamin A deficiency, such as impaired night vision, improved only after zinc supplementation. Zinc is involved in maintaining the plasma retinal binding protein (RBP), a specific transporter for vitamin A."
" Iron deficiency anemia is associated with low vitamin A status as well as reduced hemoglobin levels.19 Vitamin A apparently facilitates the mobilization of stored iron for incorporation into erythrocytes."
" The conversion of carotene to vitamin A is influenced by thyroxine. Studies show that thyroidectomy or suppression of the thyroid produces hypercarotenemia and reduced retinol levels in the liver. It has been speculated that vitamin A deficiency is associated with hypothyroidism. Studies reveal that low vitamin A levels are associated with goiter formation."
" Tissue estrogen sensitivity is increased in the presence of vitamin A deficiency. The concentrations of RBP are lowest prior to the preovulatory peak in estradiol levels. According to the study reported by Keyvani, et al, females are affected by goiter more than males due to the fact that females have lower vitamin A levels."
" The adrenocortical hormones increase the mobilization of vitamin A from the liver. This effect has also been reported in the treatment of rheumatic children with cortisone. Adequate adrenal function is also necessary for the mobilization of vitamin A stores. It is possible that adrenal and thyroid insufficiency contributes to signs of vitamin A deficiency or increased requirements due to an inability to mobilize it from storage."
" Adequate protein is necessary for the mobilization of vitamin A from the liver to the blood stream. Vitamin A deficiency is associated with protein malnutrition. Normal serum vitamin A levels can be restored when protein is added to the diet, providing there are adequate liver reserves of the vitamin. However, if liver reserves of vitamin A are depleted, dietary protein may precipitate an acute vitamin A deficiency."
Vitamin A and copper:
These findings suggest that a copper-deficient diet may cause defective transport of vitamin A from liver to blood.
Vitamin A and zinc:
I think that the right balancing of nutrients can speed up VA detox and its release from liver to blood. And the deficiency of any of the key nutrients can slow down the detox and release of VA from the liver. And so it can be very individual how quickly the liver reserves of VA run out + factors as function of ADH and ALDH enzymes, some diseases, physical activity, function of thyroid, adrenal glands. Only rice and beef diet can be very successful in the first months, but as nutrients run out or some new imbalances start as the body gets rid of VA, progress stops or slows down.
This is form Grant's five years update:
" The other diet experiment I tried was adding Brazil nuts. In theory, these nuts should have been safe; providing zinc, selenium, vitamin E, etc. But, after about two weeks, I felt I was starting to have a bad reaction to them. Of course, that bad reaction could have been a complete coincidence too. But, stopping them also seemed to coincide with resolving the negative reaction too. The negative reaction was mostly just the development of dry skin on my outer earlobes. "
I wonder if the addition of copper in brasil nuts could cause the release of VA from the liver and worsening his symptoms.
Yesterday I read this:
This diet longterm is totall deficient in copper, veryl low in potassium, calcium, magnesium, molybdenum, vitamin E, K, folate and his progress is not steady:
"So my overall mood/energy/health went from a 1 (worst I’d ever felt) before I started the diet, to a 10 (feeling amazing, best I’d felt in over a decade) after about two or three months on the VAD diet, but then after a few months gradually down to a 7 ( feeling pretty good) after a couple more months, and that’s been my “summer baseline” since then because it went down to a 5-6 over the winter and back up when summer returned."
