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Vitamin A in plasma rises when estrogen rises
Quote from
Eio on July 8, 2019, 2:49 pm
Here is an abstract that is interesting and may explain some symptoms of high vitamin A and the increase in breast cancer in oral contraceptive users.
The effect of oral contraceptives on blood vitamin A levels and the role of sex hormones.
https://www.ncbi.nlm.nih.gov/pubmed/394036
Abstract
PIP:
Blood vitamin A levels can be affected by the use of oral contraceptives (OCs). In a study conducted by Gal et al. in 1971 it was found that plasma vitamin A levels of OC users was significantly higher than in non-users for each of the evaluations during the menstrual cycle. Early observations regarding the experimental effect of OC on plasma vitamin A levels were supported epidemiologically by Smith et al. and Prasad et al. who again found that OC users have higher plasma vitamin A levels than non-users. The regular cyclic pattern of vitamin Aconcentration in blood during the menstrual cycle suggested an association between changes in sex hormones and changes in vitamin A levels. Yeung and Chan, examining whether the rise in plasma vitamin A was because of the estrogen or the progestogen component of the OC, found that the elevated levels of vitamin A observed in women OC users are due to the estrogen content in the steroid preparation. In general, it appears clear that OC treatment elevates blood vitamin A levels, but carotenese are not significantly affected. Under normal conditions, there seems to be no danger of vitamin A toxicity due to OC use, since the induced change in vitamin A levels still falls within the normal range and is accompanied by a corresponding change in retinol-binding protein (RBP). The observed increments have been about 50% in the rat and 35% in humans. Estrogenappears to be responsible for the enhancement of RBP levels that brings about a concomitant increase in blood vitamin A concentration.
Here is an abstract that is interesting and may explain some symptoms of high vitamin A and the increase in breast cancer in oral contraceptive users.
The effect of oral contraceptives on blood vitamin A levels and the role of sex hormones.
https://www.ncbi.nlm.nih.gov/pubmed/394036
Abstract
PIP:
Blood vitamin A levels can be affected by the use of oral contraceptives (OCs). In a study conducted by Gal et al. in 1971 it was found that plasma vitamin A levels of OC users was significantly higher than in non-users for each of the evaluations during the menstrual cycle. Early observations regarding the experimental effect of OC on plasma vitamin A levels were supported epidemiologically by Smith et al. and Prasad et al. who again found that OC users have higher plasma vitamin A levels than non-users. The regular cyclic pattern of vitamin Aconcentration in blood during the menstrual cycle suggested an association between changes in sex hormones and changes in vitamin A levels. Yeung and Chan, examining whether the rise in plasma vitamin A was because of the estrogen or the progestogen component of the OC, found that the elevated levels of vitamin A observed in women OC users are due to the estrogen content in the steroid preparation. In general, it appears clear that OC treatment elevates blood vitamin A levels, but carotenese are not significantly affected. Under normal conditions, there seems to be no danger of vitamin A toxicity due to OC use, since the induced change in vitamin A levels still falls within the normal range and is accompanied by a corresponding change in retinol-binding protein (RBP). The observed increments have been about 50% in the rat and 35% in humans. Estrogenappears to be responsible for the enhancement of RBP levels that brings about a concomitant increase in blood vitamin A concentration.
Quote from
ggenereux on July 8, 2019, 6:58 pm
Hi Eio,
Thanks for sharing that information. My bet is that there is also then going to be a corresponding correlation between women who have been on long term oral contraceptives and the cervical cancer rates. If true, then it could be more evidence that the HPV cancer causation hypothesis is junk science.
Grant
Hi Eio,
Thanks for sharing that information. My bet is that there is also then going to be a corresponding correlation between women who have been on long term oral contraceptives and the cervical cancer rates. If true, then it could be more evidence that the HPV cancer causation hypothesis is junk science.
Grant
Quote from
bludicka on July 8, 2019, 11:19 pm
And copper in serum rises when estrogen rises, with abnormal accumulation of copper in the brain and many women taking oral contraceptives are copper toxic:
https://www.ncbi.nlm.nih.gov/pubmed/2626984
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105953/
https://coppertoxic.com/estrogen%2Fiud
https://link.springer.com/chapter/10.1007%2F978-1-4613-0537-8_13
It can be multiple toxicity caused by long-term use of oral contraceptives.
"The birth control pill affects copper by way of estrogen. Anything that raises estrogen (as the pill does) increases copper retention, and in turn, many of the direct psychological effects of copper (especially depression and anxiety). "
And copper in serum rises when estrogen rises, with abnormal accumulation of copper in the brain and many women taking oral contraceptives are copper toxic:
https://www.ncbi.nlm.nih.gov/pubmed/2626984
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105953/
https://coppertoxic.com/estrogen%2Fiud
https://link.springer.com/chapter/10.1007%2F978-1-4613-0537-8_13
It can be multiple toxicity caused by long-term use of oral contraceptives.
"The birth control pill affects copper by way of estrogen. Anything that raises estrogen (as the pill does) increases copper retention, and in turn, many of the direct psychological effects of copper (especially depression and anxiety). "
It's interesting how the nature-intended symbiotic relationship to viruses (like hpv) is largely ignored or vilified. The more information I encounter, the more it becomes apparent that viral and bacterial infections are merely methods our bodies use as a detox fail-safe. The less toxic we are, the less likely we are to be susceptible to various illnesses.
Additionally, the increase of VA in the bloodstream as estrogen levels increase probably works to the same end by allowing our bodies to more efficiently dump VA during menstruation. This also explains why VA toxicity positively correlates with heavy bleeding. Just another toxicity fail-safe. The human race sure likes getting in the way of natural processes, don't we? Lol
It's interesting how the nature-intended symbiotic relationship to viruses (like hpv) is largely ignored or vilified. The more information I encounter, the more it becomes apparent that viral and bacterial infections are merely methods our bodies use as a detox fail-safe. The less toxic we are, the less likely we are to be susceptible to various illnesses.
Additionally, the increase of VA in the bloodstream as estrogen levels increase probably works to the same end by allowing our bodies to more efficiently dump VA during menstruation. This also explains why VA toxicity positively correlates with heavy bleeding. Just another toxicity fail-safe. The human race sure likes getting in the way of natural processes, don't we? Lol
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