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Vitamin A toxicity from Vitamin D council
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Quote from
Bella on April 18, 2019, 5:21 am
Great article! I always had low D unless I supplemented it every fall-spring until I went on low A. I successfully went through my first winter with out it! The only thing I tend to disagree with is his stance on beta carotene which seems to be a big problem for many people. Maybe that’s part of the reason so many people appear deficient in D?
Great article! I always had low D unless I supplemented it every fall-spring until I went on low A. I successfully went through my first winter with out it! The only thing I tend to disagree with is his stance on beta carotene which seems to be a big problem for many people. Maybe that’s part of the reason so many people appear deficient in D?
Quote from
YH on April 18, 2019, 8:51 am
@bella
it seems related. My vitamin d levels two summers ago came out low , despite sunbathing and taking a supplement for three months. Many members of my family also have low levels of vitamin d, despite eating fatty seafood, taking supplements, and living in sunny locations.
@bella
it seems related. My vitamin d levels two summers ago came out low , despite sunbathing and taking a supplement for three months. Many members of my family also have low levels of vitamin d, despite eating fatty seafood, taking supplements, and living in sunny locations.
Quote from
Jenny on May 10, 2019, 2:41 am
Thanks for posting interesting vitamin D council article YH. I too had very low vitamin D that I struggled to raise. I haven’t re-tested since going low A so that will be an interesting one.
Bella I agree that beta carotene is a problem for many. I’ve been looking into this & reading up on the negative feedback loop that should control the amount of beta carotene entering body. ISX is a transcription suppresser that is stimulated by retinoic acid and suppresses transcription of SCARB1 (main protein receptor allowing carotenoid absorption) & BCO1 (enzyme that cleaves carotenoids into retinal). Therefore if there is plenty of RA then absorption and conversion of carotenoids is suppressed. However, it seems to me anecdotally that this does not happen in some people with vitamin A toxicity & therefore I hypothesise that the toxicity can mess up this nice negative feedback loop & people become super absorbers & converters of beta carotene. I’ve been looking for evidence of this but most experimental work is done with VA deficiency & not toxicity. I’ve been writing a piece but I’m having a rest from it as my brain has got fried with it all!
Thanks for posting interesting vitamin D council article YH. I too had very low vitamin D that I struggled to raise. I haven’t re-tested since going low A so that will be an interesting one.
Bella I agree that beta carotene is a problem for many. I’ve been looking into this & reading up on the negative feedback loop that should control the amount of beta carotene entering body. ISX is a transcription suppresser that is stimulated by retinoic acid and suppresses transcription of SCARB1 (main protein receptor allowing carotenoid absorption) & BCO1 (enzyme that cleaves carotenoids into retinal). Therefore if there is plenty of RA then absorption and conversion of carotenoids is suppressed. However, it seems to me anecdotally that this does not happen in some people with vitamin A toxicity & therefore I hypothesise that the toxicity can mess up this nice negative feedback loop & people become super absorbers & converters of beta carotene. I’ve been looking for evidence of this but most experimental work is done with VA deficiency & not toxicity. I’ve been writing a piece but I’m having a rest from it as my brain has got fried with it all!
Quote from
Bella on May 10, 2019, 6:49 pm
Quote from
JAJ on May 10, 2019, 2:41 am
Thanks for posting interesting vitamin D council article YH. I too had very low vitamin D that I struggled to raise. I haven’t re-tested since going low A so that will be an interesting one.
Bella I agree that beta carotene is a problem for many. I’ve been looking into this & reading up on the negative feedback loop that should control the amount of beta carotene entering body. ISX is a transcription suppresser that is stimulated by retinoic acid and suppresses transcription of SCARB1 (main protein receptor allowing carotenoid absorption) & BCO1 (enzyme that cleaves carotenoids into retinal). Therefore if there is plenty of RA then absorption and conversion of carotenoids is suppressed. However, it seems to me anecdotally that this does not happen in some people with vitamin A toxicity & therefore I hypothesise that the toxicity can mess up this nice negative feedback loop & people become super absorbers & converters of beta carotene. I’ve been looking for evidence of this but most experimental work is done with VA deficiency & not toxicity. I’ve been writing a piece but I’m having a rest from it as my brain has got fried with it all!
That’s very exciting!!!
Quote from
JAJ on May 10, 2019, 2:41 am
Thanks for posting interesting vitamin D council article YH. I too had very low vitamin D that I struggled to raise. I haven’t re-tested since going low A so that will be an interesting one.
Bella I agree that beta carotene is a problem for many. I’ve been looking into this & reading up on the negative feedback loop that should control the amount of beta carotene entering body. ISX is a transcription suppresser that is stimulated by retinoic acid and suppresses transcription of SCARB1 (main protein receptor allowing carotenoid absorption) & BCO1 (enzyme that cleaves carotenoids into retinal). Therefore if there is plenty of RA then absorption and conversion of carotenoids is suppressed. However, it seems to me anecdotally that this does not happen in some people with vitamin A toxicity & therefore I hypothesise that the toxicity can mess up this nice negative feedback loop & people become super absorbers & converters of beta carotene. I’ve been looking for evidence of this but most experimental work is done with VA deficiency & not toxicity. I’ve been writing a piece but I’m having a rest from it as my brain has got fried with it all!
That’s very exciting!!!
