Quote from bludicka on November 20, 2019, 11:04 pm

https://ggenereux.blog/discussion/topic/scurvy/ 

 

"However, hypervitaminosis A was found to affect both the amount and concentration of hepatic ascorbic acid. Concentration of ascorbic acid in the livers of rats fed massive doses of vitamin A (20,000–80,000 units daily), became progressively lower as the dosage increased. When the daily dosage was 60,000 units, this decrease in ascorbic acid was detectable after only 7 days of supplementary feeding."

 

"However vitamin C had a beneficial effect against moderate excess of vitamin A. A great similarity exists between the symptoms of hypervitaminosis A as described above and the symptoms of scurvy. The complex clinical picture of hypervitaminosis A indicates an interrelation between vitamin A and vitamin C."

 

I have found this: " Vitamin C is also thought to act as an antioxidant for hepatic vitamin A stores. Animal studies have shown that vitamin A has an influence on the hepatic synthesis of ascorbic acid." (http://www.traceelements.com/Docs/The%20Nutritional%20Relationships%20of%20Vitamin%20A.pdf)

 

I take camu camu powder every day+lemon juice and these are helpful for me in vitamin A detox.

 

Maybe too much or too little vitamin A in the liver affects the production of vitamin C.

 

High doses of vitamin C - synthetic ascorbic acid used long term can reduce copper in the body. Copper is important for collagen and healthy blood vessels. Have you never tried natural vitamin C (camu camu powder...)? - it can work better with bioflavonoids -  these compounds can strengthen the walls of blood vessels and this form of vitamin C  is without disturbing the balance of some minerals in the body. I was taking larger doses of vitamin C as part of the Cutler protocol but I stopped it because after some time I had these side effects as copper dysbalance, although it worked for me in other ways as antioxidant during chelation of mercury but natural form of vitamin C worked for me much better. 

https://academic.oup.com/jn/article/127/12/2274/4728677  

https://www.ncbi.nlm.nih.gov/pubmed/9405574 

 

And vitamin K deficiency can make blood petechiae  spots because it affects bleeding. And too much vitamin A is antagonistic to vitamin K (to vitamin E, D too). And this is one of the reasons why I take supplemental vitamin K now - only low doses.

Quote from bludicka on November 20, 2019, 11:11 pm

http://www.traceelements.com/Docs/The%20Nutritional%20Relationships%20of%20Copper.pdf

"It is interesting to note a similarity of copper deficiency to vitamin C deficiency. Many changes as a result of copper deficiency can be described as "scurvy-like". Indeed many symptoms of copper and vitamin C deficiency are similar and can be difficult to distinguish. High vitamin C intake should be approached with caution until copper status is evaluated since vitamin C is known to affect copper antagonistically, and/or enzymes that require copper. The biochemical defects of copper deficiency can be described as a copper deficient scurvy (CDS). Although the mechanisms of the biochemical defects of CDS are different from those caused by vitamin C deficient scurvy, CDS can be produced by excessive vitamin C intake. Conversely, vitamin C requirements are increased by excessive copper intake or tissue accumulation. The Nutritional Relationships of Copper of CDS are different from those caused by vitamin C deficient scurvy."

Quote from Beata on November 22, 2019, 3:30 pm

Thank you for your reply and the links. I need to study this in some depth to understand the possible mechanism. 

I ordered some MitoCopper a while ago but did not start supplementing because I wanted to be well on my way with low vitamin A diet. Now that I am, it is a good time to start.

The relationship between copper and vitamin C looks like something that I need to seriously consider. 

Not sure about the natural vit C vs. ascorbic acid. Some researchers think that the AA works just fine as it is what is used in the redox processes. I wouldn’t be surprised to find that the bioflavonoids have some role to play as well.

More to learn!