I needed to disable self sign-ups because I’ve been getting too many spam-type accounts. Thanks.
Watch out for Quaker Oatmeal
https://pubmed.ncbi.nlm.nih.gov/17158229/
https://pubmed.ncbi.nlm.nih.gov/23530987/
MK-7 supplementation at doses as low as 10 μg (lower than the usual retail dose of 45 μg) significantly influenced anticoagulation sensitivity in some individuals. Hence, the use of MK-7 supplements needs to be avoided in patients receiving VKA therapy.
K2 influences clotting more than K1, a bit concerning.
@tim-2 hm and also it has really long half life so taking it every other day is more than enough.. I will take 100mcg every other day. Which will give me around 50mcg a day which should be good dose. Now when I take 200mcg a day it really feels like I have worse blood flow to the legs and arms... No wonder I felt bad on that K complex from jarrow. It has crazy amount of all 3 types of K. I had blood like maple syrup.. ;D
"In fact since vitamin K2 has a half-life of more than 3 days and is redistributed in the circulatory system via VLDL and LDL cholesterol (making it available to bone, vasculature and liver tissues), daily intakes of 45mcg of vitamin K2 means no extra supplemental K1 is needed."
Oh man you noticed worse circulation? Were you taking vD at that time? I think that they reduce the negative effects of each other to a large extent.
That sounds like a reasonable amount. I think I'll take about that or even lower.
I'm probably going to start eating some egg yolks. Choline, K2, DHA, iodine, selenium etc but also biotin, I want more of that in my diet since deficiency is associated with hair loss.
This may be a major reason why legumes are so heart healthy, if we are consuming red meat and/or eggs we definitely want to include enough molybdenum in the diet. Cabbage and olive oil also reduce TMAO as well via other mechanisms.
Detoxification of Trimethylamine N-Oxide by the Mitochondrial Amidoxime Reducing Component mARC
Abstract
Although known for years, the toxic effects of trimethylamine N-oxide (TMAO), a physiological metabolite, were just recently discovered and are currently under investigation. It is known that elevated TMAO plasma levels correlate with an elevated risk for cardiovascular disease (CVD). Even though there is a general consensus about the existence of a causal relationship between TMAO and CVD, the underlying mechanisms are not fully understood. TMAO is an oxidation product of the hepatic flavin-containing monooxygenases (FMO), mainly of isoform 3, and it is conceivable that humans also have an enzyme reversing this toxification by reducing TMAO to its precursor trimethylamine (TMA). All prokaryotic enzymes that use TMAO as a substrate have molybdenum-containing cofactors in common. Such molybdenum-containing enzymes also exist in mammals, with the so-called mitochondrial amidoxime reducing component (mARC) representing the most recently discovered mammalian molybdenum enzyme. The enzyme has been found to exist in two isoforms, mARC1 and mARC2, both being capable of reducing a variety of N-oxygenated compounds, including nonphysiological N-oxides. To investigate whether the two isoforms of this enzyme are able to reduce and detoxify TMAO, we developed a suitable analytical method and tested TMAO reduction with a recombinant enzyme system. We found that one of the two recombinant human mARC proteins, namely, hmARC1, reduces TMAO to TMA. The N-reductive activity is relatively low and identified via the kinetic parameters with Km = (30.4 ± 9.8) mM and Vmax = (100.5 ± 12.2) nmol/(mg protein·min). Nevertheless, the ubiquitous tissue expression of hmARC1 allows a continuous reduction of TMAO whereas the counter-reaction, the production of TMAO through FMO3, can take place only in the liver where FMO3 is expressed. TMAO reduction in porcine liver subfractions showed the characteristic enrichment of N-reductive activity in the outer mitochondrial membrane. TMAO reduction was also found in human cell cultures. These findings indicate the role of hmARC1 in the metabolomic pathway of TMAO, which might contribute to the prevention of CVD. This also hints at a physiological function of the molybdenum enzyme, which remains mainly unknown to date.
@tim-2 I don't understand this obsession with hair lose. I understand if woman is losing hair. That is really bad, but in males? Especially if they can grow nice beard and have good head shape for shaved head? You simply have good genetics for hair or you don't. You can't do nothing about that and I think every single person who is not delusional would agree that if your hair line is going up and up. The worst thing you can do is to trying to hide it. Because you can't hide it. Everyone see it immediately and it looks silly.. Shaved head on male will look better every single time.. So why not just shaving your head and no more wasting mental energy on pointless thing like hair is? Anyway my experience once people go through much more serious health issues than hair lose, some mild skin issues etc.. They will not worry about silly things like hair anymore..
Leap7,
How do you know Quaker Oats has Vit A? and which foods are fortified with Vit A?
M
Hi @marlene I was actually incorrect about Quaker Oatmeal currently being fortified with vitamin A. I found an article and nutrition info that said Quaker Oats added vitamin A, but those are outdated. After emailing the company, they told me that only the instant original oatmeal is fortified with vitamins and minerals (and I don't think any of those include vitamin A).
In the U.K., Quaker oats /cereals may contain weedkiller (glyphosate) linked to cancer.
Rosemary Mason paper
Click to access The_sixth_mass_extinction_and_chemicals_in_the_environment.pdf