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Whey
Is it safe? According to nutritional charts it has no or nearly no vitamin A. It doesn't have casein. It has beta-lactoglobulin, which apparently can bind retinol kind of like how retinol binding protein binds it. I tried to find information on if the beta-lactoglobulin from dairy comes pre-bound with retinol. Didn't find anything 100% superconclusive, however there are multiple papers that say that the beta-lactoglobulin in milk does not come pre-bound with any retinol.
Thoughts? Experiences?
I know Garret doesn't approve of it but i don't think he ever said anything more than "beta-lactoglobulin can bind retinol therefore it's bad".
There is a big difference in quality and the process how it is made. Cheap whey is not instant and most likely is full of lactose and will give you gas. But good quality whey protein is great source of protein.. There is basically no vit A..
I think (fermented) whey was a very common ancestral sort of thing. I don't see anything wrong with making whey from raw milk the old fashioned way, and taking some! I wouldn't touch "whey products", that is just me.
I experimented a bit with this and it didn't work out too well. I think it has retinoic acid. It's probably best to avoid any and all dairy products.
https://pubmed.ncbi.nlm.nih.gov/9742685/
If there is some retinol in whey it will be negligible amount like in beef for example.. Anyway when someone says that he tried whey. There is a huge difference in types of whey. Is it just liquid whey? Is it the cheapest dried whey? Is it 70% whey concentrate that has still a lot of lactose? Or is it high quality 90% instant whey isolate with no lactose? Or is it DH32 hydrolyzed whey? Most people will have gas and bloating from cheapest dried whey or even concentrate that is still loaded with lactose. But most people have zero issues with high quality whey isolate that has no lactose. It is like drinking water.. Whey protein is great for athletes or for people with very bad digestion. So to overcome amino acid deficiency good quality whey protein can help a lot. It is also ok for normal meals, but ideally you mix it with food. Like make some oats for breakfast and you mix in some whey.. So you slow down the absorbtion of amino acids to the blood..
I'am going to experiment with it due to this:
Commercial whey products promote intestinal barrier function with glycomacropeptide enhanced activity in downregulating bacterial endotoxin lipopolysaccharides (LPS)-induced inflammation in vitro
https://pubs.rsc.org/en/content/articlelanding/2020/fo/d0fo00487a
Cheese whey contains bioactive compounds which have shown multiple health-promoting benefits. This study aimed to assess the commercial whey products (CWP) whey protein isolate (WPI), galacto-oligosaccharide-whey protein concentrate (GOS-W) and glycomacropeptide (GMP) for their potential to improve intestinal health in vitro using HT29-MTX intestinal goblet and Caco-2 epithelial cells. Results from HT29-MTX culture showed that WPI mitigated reactive oxygen species (ROS) production at a higher extent compared to GOS-W or GMP. However, GMP downregulated the lipopolysaccharide (LPS)-induced TLR-4 inflammatory pathway with the highest potency compared to the other CWP. Biomarkers of epithelial integrity assessed on both cell lines showed tight junction proteins claudin-1, claudin-3, occludin (OCC), and zonula occludens-1 (ZO-1) upregulation by GMP in HT29-MTX (1.33–1.93-fold of control) and in Caco-2 cells (1.56–2.09-fold of control). All CWP increased transepithelial electrical resistance (TEER) in TNF-α challenged Caco-2/HT29-MTX co-culture monolayer (p < 0.05), but only GMP was similar to the positive control TGF-β1, known for its role in promoting epithelial barrier function. The TNF-α-induced co-culture monolayer permeability was prevented at similar levels by all CWP (p < 0.05). In conclusion, CWP may be used as functional food ingredients to protect against intestinal disorders with emphasis on the GMP enhanced anti-inflammatory and intestinal barrier function properties. Further in vivo studies are guaranteed to validate these findings.
[..]
Previous work has suggested a significant role exerted by milk components on epithelial barrier integrity due in part to their anti-inflammatory mechanisms. For instance, a freeze-dried low-fat yogurt was found to enhance TEER of differentiated Caco-2 monolayers subjected to LPS and pro-inflammatory cytokines challenge, and this effect was accompanied by permeability values similar to those found in vehicle controls. Overall, findings from this study suggest the potential of CWP[commercial whey products] in protecting intestinal barrier integrity, thus preventing the transport of bacteria and toxins to the systemic circulation and promoting gut homeostasis.
I just want to reiterate, I recommend everyone who is trying to detoxify VA to avoid all dairy, including whey. Personally I think that you might as well just drop the whole idea of detoxifying VA alltogether if you're going to consume dairy foods.
Quote from salt on May 8, 2021, 1:16 pmI just want to reiterate, I recommend everyone who is trying to detoxify VA to avoid all dairy, including whey. Personally I think that you might as well just drop the whole idea of detoxifying VA alltogether if you're going to consume dairy foods.
What did you experience with it for being so against it?
I was sick with cold-like symptoms for 2 weeks straight until I realized the whey protein smoothies were the cause. It was somewhat cheap though, so it might be why. It could also have been some die off. It supposedly help with glutathione.
I've checked whey and it seems to modulate(suppress) immunity which is not the thing to look forward I think, since most of the times it equals a trade-of between relatively short term remission vs long term relapse(like in marginal keto/veg diets, drug/supplements people use/abuse, etc)
Effect of Whey Supplementation on Circulating C-Reactive Protein: A Meta-Analysis of Randomized Controlled Trials
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344580/
Whey supplementation is beneficial for human health, possibly by reducing the circulating C-reactive protein (CRP) level, a sensitive marker of inflammation. Thus, a meta-analysis of randomized controlled trials was conducted to evaluate their relationship. A systematic literature search was conducted in July, 2014, to identify eligible studies. Either a fixed-effects model or a random-effects model was used to calculate pooled effects. The meta-analysis results of nine trials showed a slight, but no significant, reduction of 0.42 mg/L (95% CI −0.96, 0.13) in CRP level with the supplementation of whey protein and its derivates. Relatively high heterogeneity across studies was observed. Subgroup analyses showed that whey significantly lowered CRP by 0.72 mg/L (95% CI −0.97, −0.47) among trials with a daily whey dose ≥20 g/day and by 0.67 mg/L (95% CI −1.21, −0.14) among trials with baseline CRP ≥3 mg/L. Meta-regression analysis revealed that the baseline CRP level was a potential effect modifier of whey supplementation in reducing CRP. In conclusion, our meta-analysis did not find sufficient evidence that whey and its derivates elicited a beneficial effect in reducing circulating CRP. However, they may significantly reduce CRP among participants with highly supplemental doses or increased baseline CRP levels.
It could also have been some die off.
It is possible but at what price - you could be killing some innocent bacteria while downregulating immunity against really nasty pathogens with whey.