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Why some of us are sensitive to oxalates on low VA diet
https://pubmed.ncbi.nlm.nih.gov/2097329/
"The intestinal uptake of [14C]oxalate, [14C]glyoxylate, and [14C]glycolate are studied in brush border membrane vesicles (BBMV) isolated from vitamin A-deficient and pair-fed control rats. The data obtained indicate that oxalate and its precursors are transported across the BBMV by passive diffusion. The intestinal uptake of glyoxylate and glycolate remains unaltered in vitamin A deficiency, while uptake rate of oxalate was significantly increased (p less than 0.01) in vitamin A-deficient rats as compared to pair-fed controls. In conclusion, the results indicate that vitamin A deficiency leads to hyperabsorption of oxalate through the gut."
We know that vitamin A deficiency = vitamin A detoxification. This is not surprising.
Quote from Даниил on August 27, 2021, 10:41 amhttps://pubmed.ncbi.nlm.nih.gov/2097329/
"The intestinal uptake of [14C]oxalate, [14C]glyoxylate, and [14C]glycolate are studied in brush border membrane vesicles (BBMV) isolated from vitamin A-deficient and pair-fed control rats. The data obtained indicate that oxalate and its precursors are transported across the BBMV by passive diffusion. The intestinal uptake of glyoxylate and glycolate remains unaltered in vitamin A deficiency, while uptake rate of oxalate was significantly increased (p less than 0.01) in vitamin A-deficient rats as compared to pair-fed controls. In conclusion, the results indicate that vitamin A deficiency leads to hyperabsorption of oxalate through the gut."
We know that vitamin A deficiency = vitamin A detoxification. This is not surprising.
Very interesting. I have felt significantly more oxalate symptoms since going lower A (only a week or so in so nothing really to go on yet) I am trying to avoid all high to medium ox things but having a lot more than prior so I thought it was just that.. I wonder if perhaps carnivore or meat and rice would be the safest option for the oxalate sensitive so as not to be worsening ox during A detox..
I can't bring myself to go strict however. I think I have diet fatigue. So I'll keep on for a while trying to be as low ox as I can comfortably while continuing to find a rhythm of low to no A foods as well.
Yes everything is worse when hormones fly! My chronic vomiting attacks were often associated with hormonal times. The detox pathways are very busy then, I suppose, triggering my innate "You've been poisoned" button.
I have often wondered why some women get hot flashes and others don't. I know two women who live together and have similar diet and environment and one gets them and the other doesn't.
Didn't you suggest that hot-flash women are just not processing hormones out of the body efficiently the way their cooler friends are?? Sounds like this could be the difference. I just posted about Griffin's acne (I've had acne of various types all my years) and wonder if acne is also about fertility hormones hanging around that should have been processed out of the body in better time.
What originally starts the clogged detox pathway? Maybe that question has different answers for different people... Some of us may be born with poor detox (such as weak kidneys) and some of us may have poor detox thrust upon us by our dietary choices. (VA overload or maybe alcoholism). There may be other reasons.
Some people inadvertently receive exogenous hormones from the environment (ag chemicals?) or food (for instance, flax seed or pomegranate) and those might be confusing the issue too.
Week 1 and 2 all hormones are fairly low they start going back up towards the middle of the month. So it sounds like liver dysfunction. Remember our liver needs glucose to be energized.
I've never heard anyone say week 4 has low hormones, they drop off right before the bleeding starts, hormones are off the charts for many women premenstrually. We feel relief when the bleeding starts because levels have dropped the lowest they will be the entire month.
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