Discussion

I needed to disable self sign-ups because I’ve been getting too many spam-type accounts. Thanks.

Forum Navigation
Please to create posts and topics.

YCT-529 male contraceptive pill. works by.... blocking RA receptor !!!

 the claim is that this molecule blocks RETINOIC ACID receptors, hence, blocking sperm production. 99% efficacy after few weeks of use.  any thoughts of such sensational claim?  it goes against all we know and discuss  here . 

implies that RETINOIC ACID is not only nontoxic, but.... drumrolll......   ESSENTIAL for fertility  !!

  https://twin-cities.umn.edu/news-events/first-hormone-free-male-birth-control-pill-clears-another-milestone 

i would like to hear from the community, and exp. from Grant on this matter 

Joe2 has reacted to this post.
Joe2
Blocking retinoic acid receptors (RARs) reduces CYP26 enzyme expression, which slows retinoic acid  catabolism. This results in more RA buildup, which can lead to fertility issues.
 
Nobody claims that retinoic acid is a plain toxin; it has important uses in the body. However, many have a low functional CYP enzymes due to glyphosate and supplements like EGCG and berberine, which inhibit the enzymes needed to process retinol and for RA catabolism.
 
I don’t recommend following Smith’s recommendation with its high zinc intake combined with a very low retinol diet. Zinc supplementation prioritizes RA production, depleting retinol in the process. In the long run, this can cause problems with low dopamine signaling, reduced RA signaling with symptoms like low motivation,mood ,vision problem and similar issues...
Joe2 has reacted to this post.
Joe2

As an aside, whenever people talk about possibly using birth control with bad side effects, I always like to mention that you can take control of your fertility without any such risks.

There is a book called "Taking Control of Your Fertility" by Weshler and also a website.

For men, the easiest thing and always available... coitus interruptus... which I'm sure is how people have always done it through history.

Of course the ultimate situation is you have a mate who is also on the same page and can plot her cycles and gain even more control so that you know when to interrupt and when you can get away with not interrupting.    

And of course it is always nice that when "life finds a way" you are OK with that and consider it "dancing instructions from the universe".   (all forms of birth control can fail, btw)

Husband and I used these sorts of methods (and occasionally lamb condoms).   25 years, no oops.   The skills can also be used to become pregnant when that is desired, and that is powerful too!   

Hermes and Joe2 have reacted to this post.
HermesJoe2
Quote from Arios on July 26, 2025, 2:19 am
 
Nobody claims that retinoic acid is a plain toxin; it has important uses in the body. However, many have a low functional CYP enzymes due to glyphosate and supplements like EGCG and berberine, which inhibit the enzymes needed to process retinol and for RA catabolism.

Click to access PoisoningForProfits.pdf

Poisoning For Profits

(24821) Poisoning For Profits by Grant Genereux: The Sub Clinical Vitamin A Poisoning Pandemic - YouTube

lil chick has reacted to this post.
lil chick
Scroll to Top