I needed to disable self sign-ups because I’ve been getting too many spam-type accounts. Thanks.
Eggs as part of Vitamin A reduction
Quote from El on August 4, 2023, 11:51 pm
Yeah ! 🙂 but as far as I understand, wether you are an over or under-methylater will greatly affect the outcome of methinone restriction. It will have the opposite effect restricting it if you are on the "wrong side" .
My understanding is that methionine isn't a big deal as long as you are getting enough glycine in your diet.
Quote from Chris on August 5, 2023, 2:50 pmMy understanding is that methionine isn't a big deal as long as you are getting enough glycine in your diet.
well its more like if you get glycine in sufficient dosis it blocks the methionine as it uses (at least partly) the same pathways or at least glycine blocks methionine. So glycine suplementation is an internal methionine restriction. Intrestingly enough I stopped having benefits from glycine/gelatin after about 2 years?on the vit A diet. And vitamin A is supposedly affecting methionine metabolism, which is one reason as Smith mentions (I belive correctly) that under/over methylation normalizes on the low A diet with time usually
Unsaturated fat causes brain edema, unsaturated fat takes 4 years to leave the body, inhibits choline absorption and blocks acetylcholine production.
In a variety of cell types, vitamin A functions as an estrogen antagonist, inhibiting cell division and promoting or maintaining a state of functioning. Promotes protein synthesis, regulates lysosomes, and protects against lipid peroxidation. Just as stress and estrogen toxicity mimic aging, so does vitamin A deficiency. While its known roles are varied, I believe the largest use of vitamin A is for the production of pregnenolone, progesterone and other steroids associated with youth. One of the important functions of vitamin E is to protect vitamin A from destructive oxidation. Although little attention has been paid to the effects of unsaturated fats on vitamin A, their destruction of vitamin E will necessarily lead to the destruction of vitamin A.
In order to produce pregnenolone, the thyroid, vitamin A, and cholesterol must reach the mitochondria in the proper ratio and in sufficient quantity. Normally, stress is balanced by increased synthesis of pregnenolone, which improves the ability to cope with stress. Lipid peroxidation, resulting from the accumulation of unsaturated fatty acids, iron, and energy deficiency, impairs the ability of mitochondria to produce pregnenolone. When pregnenolone is inadequate, excess cortisol is produced. When progesterone is deficient, the effect of estrogen is unopposed. When both thyroid and progesterone are deficient, even fat cells synthesize estrogen. They are promoting a myth about human nature, so I will present a counter-myth. At the time when people were developing their big brains, they lived in the tropics. I suggest that at this time before the development of grain-based agriculture, they ate a diet relatively free of unsaturated fat and low in iron, based on tropical fruits. I suggest that the Boskop skull from Mount Kilimanjaro was representative of people in those conditions, and that from our current knowledge of the association of brain size with longevity alone, they, as various "Golden Age" myths claim, must have had a very long useful life. As people moved north and developed new ways of life, their consumption of unsaturated fats increased and their brains and lifespans decreased.
Traducción en directo
Enviar comentarios
Otras personas también buscan
translate.google.es
https://translate.google.es › ...
Traductor de Google
El servicio de Google, que se ofrece sin coste económico, traduce al instante palabras, frases y páginas web a más de 100 idiomas.
Google Translate
Inicia la sessió
Google Play
Traductor de Google
Traductor de Google
4.4
(8,7 M)
Traducción de textos: traduce entre 108 idiomas con el teclado • Tocar para Traducir: copia el texto de cualquier aplicación y toca el icono del Traductor ...
translate.google.com
https://translate.google.com › ...
Traductor
El servicio de Google, que se ofrece sin costo, traduce al instante palabras, frases y
Quote from El on August 10, 2023, 9:09 am
Unsaturated fat causes brain edema, unsaturated fat takes 4 years to leave the body, inhibits choline absorption and blocks acetylcholine production.
In a variety of cell types, vitamin A functions as an estrogen antagonist, inhibiting cell division and promoting or maintaining a state of functioning. Promotes protein synthesis, regulates lysosomes, and protects against lipid peroxidation. Just as stress and estrogen toxicity mimic aging, so does vitamin A deficiency. While its known roles are varied, I believe the largest use of vitamin A is for the production of pregnenolone, progesterone and other steroids associated with youth. One of the important functions of vitamin E is to protect vitamin A from destructive oxidation. Although little attention has been paid to the effects of unsaturated fats on vitamin A, their destruction of vitamin E will necessarily lead to the destruction of vitamin A.In order to produce pregnenolone, the thyroid, vitamin A, and cholesterol must reach the mitochondria in the proper ratio and in sufficient quantity. Normally, stress is balanced by increased synthesis of pregnenolone, which improves the ability to cope with stress. Lipid peroxidation, resulting from the accumulation of unsaturated fatty acids, iron, and energy deficiency, impairs the ability of mitochondria to produce pregnenolone. When pregnenolone is inadequate, excess cortisol is produced. When progesterone is deficient, the effect of estrogen is unopposed. When both thyroid and progesterone are deficient, even fat cells synthesize estrogen. They are promoting a myth about human nature, so I will present a counter-myth. At the time when people were developing their big brains, they lived in the tropics. I suggest that at this time before the development of grain-based agriculture, they ate a diet relatively free of unsaturated fat and low in iron, based on tropical fruits. I suggest that the Boskop skull from Mount Kilimanjaro was representative of people in those conditions, and that from our current knowledge of the association of brain size with longevity alone, they, as various "Golden Age" myths claim, must have had a very long useful life. As people moved north and developed new ways of life, their consumption of unsaturated fats increased and their brains and lifespans decreased.
Traducción en directo
Enviar comentarios
Otras personas también buscantranslate.google.es
https://translate.google.es › ...
Traductor de Google
El servicio de Google, que se ofrece sin coste económico, traduce al instante palabras, frases y páginas web a más de 100 idiomas.
Google Translate
Inicia la sessió
Google Play
Traductor de Google
Traductor de Google
4.4
(8,7 M)
Traducción de textos: traduce entre 108 idiomas con el teclado • Tocar para Traducir: copia el texto de cualquier aplicación y toca el icono del Traductor ...translate.google.com
https://translate.google.com › ...
Traductor
El servicio de Google, que se ofrece sin costo, traduce al instante palabras, frases y
@grant
Quote from El on August 10, 2023, 9:09 am
Unsaturated fat causes brain edema, unsaturated fat takes 4 years to leave the body, inhibits choline absorption and blocks acetylcholine production.
In a variety of cell types, vitamin A functions as an estrogen antagonist, inhibiting cell division and promoting or maintaining a state of functioning. Promotes protein synthesis, regulates lysosomes, and protects against lipid peroxidation. Just as stress and estrogen toxicity mimic aging, so does vitamin A deficiency. While its known roles are varied, I believe the largest use of vitamin A is for the production of pregnenolone, progesterone and other steroids associated with youth. One of the important functions of vitamin E is to protect vitamin A from destructive oxidation. Although little attention has been paid to the effects of unsaturated fats on vitamin A, their destruction of vitamin E will necessarily lead to the destruction of vitamin A.In order to produce pregnenolone, the thyroid, vitamin A, and cholesterol must reach the mitochondria in the proper ratio and in sufficient quantity. Normally, stress is balanced by increased synthesis of pregnenolone, which improves the ability to cope with stress. Lipid peroxidation, resulting from the accumulation of unsaturated fatty acids, iron, and energy deficiency, impairs the ability of mitochondria to produce pregnenolone. When pregnenolone is inadequate, excess cortisol is produced. When progesterone is deficient, the effect of estrogen is unopposed. When both thyroid and progesterone are deficient, even fat cells synthesize estrogen. They are promoting a myth about human nature, so I will present a counter-myth. At the time when people were developing their big brains, they lived in the tropics. I suggest that at this time before the development of grain-based agriculture, they ate a diet relatively free of unsaturated fat and low in iron, based on tropical fruits. I suggest that the Boskop skull from Mount Kilimanjaro was representative of people in those conditions, and that from our current knowledge of the association of brain size with longevity alone, they, as various "Golden Age" myths claim, must have had a very long useful life. As people moved north and developed new ways of life, their consumption of unsaturated fats increased and their brains and lifespans decreased.
Traducción en directo
Enviar comentarios
Otras personas también buscantranslate.google.es
https://translate.google.es › ...
Traductor de Google
El servicio de Google, que se ofrece sin coste económico, traduce al instante palabras, frases y páginas web a más de 100 idiomas.
Google Translate
Inicia la sessió
Google Play
Traductor de Google
Traductor de Google
4.4
(8,7 M)
Traducción de textos: traduce entre 108 idiomas con el teclado • Tocar para Traducir: copia el texto de cualquier aplicación y toca el icono del Traductor ...translate.google.com
https://translate.google.com › ...
Traductor
El servicio de Google, que se ofrece sin costo, traduce al instante palabras, frases y
While I agree with the pufa thing and many of the things you describe are correct seen individually (the hormones) the problem with that line of thinking is.... Grant and several others like Smith and myself have had no such hormonal problems on low/no A and rather had the opposite effect of bettering hormone profiles. Its also debateable wether the brains developed in the tropics though I know that to be the mainstream concensus. I just think its a bit easy handling of the subject. I should mention I have developed severe hypervitaminosis A while beeing on superlow pufa for at least 11 years
Quote from wavygravygadzooks on July 20, 2023, 12:04 pmUntil we see direct measurements of the amount of Vitamin A in Grant's food and stored in his liver, I personally find the wide variety of evidence (particularly the evolutionary logic) supporting the nutritive role of retinol and its derivatives more compelling than Grant's n=1.
What I do think is very valuable from Grant's self-experiment is knowing that certain people under certain living conditions can apparently be quite healthy with minimal intake of Vitamin A, as well as (and I actually find this more interesting myself) minimal amounts of Vitamin C on a carb-based diet. The abundance of people on carnivore diets without Vitamin C deficiency pretty well establishes the minimal need for that vitamin on such a diet, but one of the main hypotheses for that being the case is that the absence of carbohydrates in the diet enables the tiny amounts of Vitamin C in meat to be completely absorbed and utilized in the cells that need it. Based on Grant's experience, it may be far important that the uric acid from lean meat replaces the need for the antioxidant capacity of Vitamin C, and that the amino acids found in meat are essentially all that is needed for maintenance of collagen in the body.
wide variety of evidence?
have you not read Grant's books that outline the fraudulent science throughout the vit A industry?
Quote from Andrew B on November 5, 2022, 2:21 am@ggenereux2014 Let's think about eggs logically in connection with living and Vitamin A reduction (VAR). Some say Vitamin A reduction is more important than living itself and that's okay too. The fluffy stuff first. Eggs are useful for baking and making apple sponges, pancakes, French toast, fishcakes, beef burgers and having with a fryup. Butter is very useful in baking also although you can make an apple sponge with eggs and no butter. Butter is the preferred healthy option for spreading on your bread, toast, scones, potatoes and vegetables. Butter is tasty for frying mushrooms.Choline first. Someone doing a very simple VAR could eat only beef and a few beans and get plenty of choline. 400 grams of beef each day plus 150 grams of beans would get 520 mgs of choline per day. That's average and possible perhaps more so for men. To get much more choline for various reasons you would need to eat about 800 grams of beef. Some men (and women) do eat this much so it's possible. Some people have done this and get good results reducing vitamin A and improving liver health. You would have to think the choline (and serine) is helping the person and not hindering. It could be the protein and zinc as the main factors and the choline could be the hindrance. It seems unlikely because adequate intake of choline is meant to be 550 mgs for men and 425 mgs for women. The upper limit is nearer 3.5 grams.A man could eat the first 400 grams of beef and not be able to each much more. So he chooses to eat just over 3 eggs a day to give him the equivalent of the extra 400 mgs of choline. The high beef eating man succeeded probably in all likelihood because of the choline so a lower eating beef man eating 3 protein rich eggs with selenium, folate, B2, zinc and other factors is just as likely to succeed all things being equal.Vitamin A second. One tablepoon of butter gives you about 325 IUs of vitamin A (incidentally also 2.7 mgs of choline, all fat and no protein). Two scrambled eggs will give you 564 IUs of vitamin A so 282 IUs per egg. A fried egg will give you 330 IUs (146 mgs of choline to help you digest the lower fat in eggs and loads of protein). The USDA gives lower figures for vitamin A in eggs generally but let's keep baking for now. They are roughly equivalent with the higher numbers I found. If you're currently having 2 tablespoons of butter each day on your bread and succeeding with VAR then there's no worry in switching to 2 eggs on the basis of the vitamin A. You could even mix and match one egg and one tablespoon of butter each day. Talk about living on the edgeThirdly and lastly cholesterol. There's about 185 mgs of cholesterol in one large egg. There's about 31 mgs of cholesterol in one tablespoon of butter. In 100 grams of beef burger there's 89 mgs of cholesterol. So going back to the man eating 800 grams of beef each day in a beef burger format then he's getting 712 mgs of cholesterol yet he's still succeeding with VAR. The man eating 400 grams of beef adding the 3 eggs will get 911 mgs of cholesterol. Is this man who is doing VAR and is probably in the healthiest section of the population now going to keel over and die because of the extra 199 mgs of dietary cholesterol ? Bearing in mind his detox and digestion systems may be working better than the high beef eating man (because of the lecithin in the eggs). The high beef eating man would also get 62 mgs of cholesterol if he enjoys 2 tablespoons of butter each day. Did I say enjoy ? Sorry about that. What was I thinking ? God forbid we actually enjoy eating and living.Dietary cholesterol (esterified form) is not the same as endogenously produced cholesterol (free form). Cholesterol is essential for life. It's complicated though. Do the extra nutrients in eggs like selenium, choline and folate actually compensate for the loss in particular of zinc in beef ? In Japan they eat nearly one egg per person per day and live the longest but there are many factors involved. At the level of 3 eggs per day the man eating 400 grams of beef still skews the balance of his diet to beef rightly or wrongly. There seems to be a small risk in dietary studies from eating more and more cholesterol. Eating lots of eggs may be part of an unhealthy diet and therefore the mortality risk increases. But what I want to know is whether it's bad for longevity for this now very healthy man doing VAR to eat 3 eggs a day ? Life, experimentation and vitamin A reduction continues.
where did anyone say that vit A reduction is more important than life itself?
where did Grant not look at this topic logically?
I still enjoy a few outstanding cigars and fewer cigarettes. Even when I can come up with great ways to incorporate them into my life and they are extremely useful in keeping bugs away in the back yard, these are hardly arguments for calling anything in tobacco a nutrient. So no, I am not going to advocate smoking to improve my endurance sports. Nor sprinting sports. nor any sports. What you advocate with eggs is similar. Eggs are not aiding detox. They are aiding absorption of vit A and other fat based toxins and nutrients. Eating 4 or 5 eggs is day is abherrant behavior. Suggest you join LiverKing in his pursuits. Remember this is coming from a chicken owner who used to eat 2 to 12 eggs per day for years.
The crux of all you wrote here is ignoring the significance and import of what Grant's experiment and success brings to us. You have worked hard to give yourself access to all the various foods you grew up with and love. The dancing around details of nutrient like choline and others is the equivalent of flying a 747 with zero previous experience and a aircraft manual open in your lap. Meanwhile Garrett and Grant are running long term real time experiements individualized to people with varied problems and getting results and adjusting their approaches to these results.
Glad you are feeling better. Paul Saladino is too. Brian Johnston gives a good clue as to where Paul Saladino is headed without serious changes in his perspective. So far he adjusted his approach from straight meat to meat with honey all over it. Again another abherrant approach. Now he is gobbing in fruit. Garrett has brought out repeatedly studies that show long term results of combining high fat high carb diets. He has also brought out many long term looks at egg consumption and longevity.
I request you drop all ad hominem tactics and start siting links to studies that support your beliefs. Even if you are getting great results with your eggsperiment, you might be mislabeling it as vit A reduction or as copper reduction. If you do not see these two as toxins, then you reasons for being on this blog are more suspect.
Looking forward to your reply.
@joe
It seems you have not read my many rebuttals to Grant's assertions. It takes a lot of time and background scientific knowledge to truly understand what can be concluded from any given publication, and almost every time I see Grant or dipSmith post their assessment of a given publication it is abundantly clear that they either didn't bother to read it in its entirety, didn't understand its limitations, or didn't understand it period. I'm a research biologist and half the papers I see them referencing make my head spin with all the minutiae and jargon from specialized disciplines like biochemistry. There is simply no way they have sufficient understanding of all these specialized areas of science to truly understand many of these publications. It is also clear they have no real grasp of statistics and its application to studying biological systems. See, for example, my post here explaining why Grant himself has not and cannot prove that Vitamin A is a toxin: https://ggenereux.blog/discussion/topic/scientific-realities-understanding-the-inferential-limitations-of-data/#postid-24479