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Quote from
David on July 15, 2023, 6:53 pm
@robc
I don't know of any human studies on toxins in the ear but here is a interesting 26 page study from 1978 on the inner ear and vitamin A in the guinea pig:
"EXPERIMENTAL STUDIES ON THE ROLE OF
VITAMIN A IN THE INNER EAR" by Richard A. Chole.
DOI: https://doi.org/10.1177/01945998780860s411 (available at sci-hub)
Quote from the discussion on how extremely high the concentration of vitamin A in the inner ear was, as evident from the attached figure:
"Compounds with vitamin A activity are found in all mammalian tissues in the range of 1 microg/gm of tissue (Sauberlich, Hodges, Wallace, et al 1974,47). The main storage site of vitamin A is the parenchymal cell of the liver (Sherman, 1969,48). The vitamin A concentration of liver varies widely from species to species but is generally at least one order of magnitude [x10] higher than other tissues. The concentration of vitamin A in the pooled tissue of the inner ear of the guinea pig is ten times as high as these other tissues."
@robc
I don't know of any human studies on toxins in the ear but here is a interesting 26 page study from 1978 on the inner ear and vitamin A in the guinea pig:
"EXPERIMENTAL STUDIES ON THE ROLE OF
VITAMIN A IN THE INNER EAR" by Richard A. Chole.
DOI: https://doi.org/10.1177/01945998780860s411 (available at sci-hub)
Quote from the discussion on how extremely high the concentration of vitamin A in the inner ear was, as evident from the attached figure:
"Compounds with vitamin A activity are found in all mammalian tissues in the range of 1 microg/gm of tissue (Sauberlich, Hodges, Wallace, et al 1974,47). The main storage site of vitamin A is the parenchymal cell of the liver (Sherman, 1969,48). The vitamin A concentration of liver varies widely from species to species but is generally at least one order of magnitude [x10] higher than other tissues. The concentration of vitamin A in the pooled tissue of the inner ear of the guinea pig is ten times as high as these other tissues."
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