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Is most of vitamin A removed through breath and urine, not bile?

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Quote from Joe on August 28, 2024, 12:07 am
Quote from Janelle525 on August 27, 2024, 6:45 am

@joe

It wasn't quite clear who you were speaking to in the last comment?

Also my comment about vegans was to point out that no one questions when someone overdoes meat, but they always question when they overdo anything else. It's hypocritical. But hypocritical attitudes are rampant in health communities I think everyone has some hypocritical beliefs. I don't think Grant's meat intake is excessive though. My husband's maybe lol. He's carnivore. I wonder about his iron. He is rapidly losing hair and looking older and waking up at 5 am after only 6 hours of sleep. Carnivore is massively overhyped. It's a weight loss and inuslin resistance tool. That's about it. 

My biggest beef about carnivore (get it?) is that how likely is someone going to be able to get sufficient quantities of beef for years or decades?  There are going to be times where less if any beef will be available.  Shawn Baker is painted into a corner right now.   He burnt his bifido away awhile back.  Eating an apple crippled him for 3 days.   Unfortunately for him he has little experience and study in other paradigms.  

When I crashed with sacroiliitis 11/2022, I had been paleo keto 12 years.  I knew immediately that a lack of wheat was not my problem.  I also learned immediately that eating any more liver was not possible.  I learned in a few short weeks that I needed to get back to carbs.  Fortunately I had studied and worked with Zone diet previous 15 years.  I knew how to carefully get from zero carbs to a bearable load of carbs fairly quickly.  I was also familiar with what it would take to get back to keto if I changed my mind.  Most have no clue let alone experience.   I had 29 years of study, mentoring and experience. 

When I found Grant and Garrett, it was much easier to hold their ideas up against my previous 43 years (high calorie lacto ovo 14 years) of study, training, testing and experience.  Garrett's ideas on the transition were spot on.  He dabbled in low carb a little but never did carnivore.  He was smart enough to admit that up front.  

Have talked with Shawn Baker a few times.  He is slowly realizing he is cornered and needs to work out an exit strategy.  He had disc problems last year that scream that he needs to stop eggs completely.  This is probably why he gave Thor Thorens 50 minutes on a podcast.   Obvious he still wants to stay carnivore.   Also obvious his time and options are running out.  He knows Thor has similar and long experience.  He will need Thor's help soon.  

Ok that is my ramble.   If nothing else your husband deserves credit.  He is experimenting.  Hope he is studying too.   Many good people out there working on making it work better.   LYL has a few new carnivores who are cancer survivors too.  One is 10 years in on a 2 year diagnosis.  She found that when she tried to bring back carbs, her tumors grew.  So now she is working out how to bring charcoal and fiber in while she stays carnivore.  And tumors are stable.  Will be wild when she groks copper binders and starts pulling copper out.   

The list of folk on LYL coming from years of carnivore is growing fast.  Interesting takes on diet.  

As to hypocrisy, um that is interesting.  In all my diets for last 50 years, I have never had a moment where people did not ask questions and tell me I am crazy.  While they ate their jello dessert / salad and their macaroni and cheese main course both from boxes.  Walking around the block was difficult for them while we were training daily and working long hours.  Reminds me of the articles during covid where we were told it is a bad idea to do our own research.   Only professional scientists should try to understand science.   Curious to read someone on this blog criticize me for being a cult / guru follower for studying and trying different paradigms.   Everyone one of those transitions took study, trial and error and skill building.  And every one of those paradigms relieved symptoms from previous decades while enhancing performance in strength and endurance.  

But yeh whatever.   Just a cult follower.  Not a real sciency person like those who ignore Grant's facts while writing dismissive junk on his blog.  Reminds me of seeing people on LYL who pay the $100 to write comments on a blog about how the blog is dumb and not worth $100.   Makes me curious about people on this blog who put serious hours in every week here while doing backflips trying to make it sound like Grant is wrong or impertinent.  

 

Yikes! eating an apple destroyed him for 3 days?? That's really not good. At least my husband can cheat about once month and not even notice a difference. But his diet was never high in eggs or organ meats or cream or carrots (he hates veggies except mustard, chili powder, garlic and onions). But yeah he will have to experiment. That's great for the cancer survivors. Sounds like an insulin problem, carbs seem to fuel tumor growth in their case. Like I said the main benefit of keto is insulin problems. 

Oh yeah don't get me started on the people who said 'don't do your own research, trust Fauci!'.... while they were all lining up for their booster shots and still getting covid. The fear mongering worked. 

Just keep doing what you are doing if it is working. I think we all need to find what works. We certainly can't convince anyone to do exactly like we do, they have to come to that conclusion on their own. 

Quote from Paola on August 23, 2024, 12:47 pm

Take a look at the following study: Vitamin A Metabolism and Requirements in the Human Studied with the Use of Labeled Retinol  https://annas-archive.org/scidb/10.1016/S0083-6729(08)60015-1

7 patients received radioactive retinyl acetate intravenously, 1 patient received it orally. Their breath, urine, and feces were monitored for 177 days afterwards. The radioactivity of the bodily fluids and excrements was measured to determine how fast the retinyl acetate was excreted and how.

Results: Most vit A was released via BREATH and URINE, only a minor part was released in bile. 

 

I would love to see this re-done with a better "depletion diet". And, the assay to include other forms of Vitamin A (specifically Vitamin A2)

With multiple persons on the casein diet (or casein / soy), they were likely getting an amount of anhydroretinol / dehydroretinol (or "Vitamin A2"). 

So, I can't really take the keratinosis and other symptoms seriously. 

BUT, the finding that a certain amount of Vitamin A is eliminated through the breath, urine (and likely skin) seems reasonable. In fact, a lot of the metabolites of Vitamin A in the liver detox pathways likely end up as water soluble forms that do get eliminated.

Anecdotally, I urinate a lot overnight when I drink too much mineral water (which has sulfate). Pellegrino (which has LOTS of Sulfate) is by far the worse. Even now two year out.

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Quote from Paola on August 23, 2024, 12:47 pm

Take a look at the following study: Vitamin A Metabolism and Requirements in the Human Studied with the Use of Labeled Retinol  https://annas-archive.org/scidb/10.1016/S0083-6729(08)60015-1

7 patients received radioactive retinyl acetate intravenously, 1 patient received it orally. Their breath, urine, and feces were monitored for 177 days afterwards. The radioactivity of the bodily fluids and excrements was measured to determine how fast the retinyl acetate was excreted and how.

Results: Most vit A was released via BREATH and URINE, only a minor part was released in bile. 

Unfortunately, given that they received retinyl acetate (which is not present in food, as far as I understand) intravenously (except for one guy), it is not clear how applicable this is to real life retinol metabolism. 

But IF it is, then this could potentially explain why high fiber low vit A dieters tend to have a harder time than low vit A zero fiber carnivores. 

@paola

Do we know if that radiolabeled carbon remained attached to the Vitamin A compounds as they were metabolized?  I think this study provides insight into the rate of Vitamin A metabolism but not necessarily the routes of excretion.  The routes of excretion in the study may only apply to carbon.

There was a rat study that looked at radiolabeled Vitamin A that, if I remember correctly, used a different type of labeling and accounted for Vitamin A in the stool and urine.  Would be good to compare the results with this study.

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