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Push/Pull of protein and fat…but where do carbs stand?
Quote from
lil chick on July 26, 2021, 3:10 pm
carbs carbon cabohydrates... I actually don't think that carbs are the enemy. An old guy I know made me realize that there IS a difference between sugar and starch. He is very big on oatmeal... he's 90...
I think we (but especially we here on the VA detox) need to get enough calories in the least toxic way. That is the simplest way to put it.
carbs carbon cabohydrates... I actually don't think that carbs are the enemy. An old guy I know made me realize that there IS a difference between sugar and starch. He is very big on oatmeal... he's 90...
I think we (but especially we here on the VA detox) need to get enough calories in the least toxic way. That is the simplest way to put it.
Даниил has reacted to this post.
Quote from
Kurtis on July 27, 2021, 2:53 am
Maybe lipolysis is a factor here
https://pubmed.ncbi.nlm.nih.gov/1127357/
We suggest that the toxic manifestations of hypervitaminosis A occur when vitamin A circulates in plasma and is presented to membranes in a form other than bound to RBP. Plasma lipoproteins may nonspecificially deliver vitamin A to biological membranes and hence lead to vitamin A toxicity.
Enzymes involved in lipolysis also mobilize VA in the liver
https://www.sciencedirect.com/science/article/abs/pii/S1388198119300873
In conclusion, HSL participates in vitamin A metabolism in qHSC. Equivalent activities of ATGL and ADPN provide the healthy liver with multiple routes to control circulating retinol levels.
Lipolysis is activated by a large number of things, I assume VA is hydrolyzed out of storage in the liver when serum RBP falls below a certain point, but considering lipolysis is stimulated by many other things, maybe VA is pulled out during times of increased lipolysis without a RBP to capture it?
Maybe lipolysis is a factor here
https://pubmed.ncbi.nlm.nih.gov/1127357/
We suggest that the toxic manifestations of hypervitaminosis A occur when vitamin A circulates in plasma and is presented to membranes in a form other than bound to RBP. Plasma lipoproteins may nonspecificially deliver vitamin A to biological membranes and hence lead to vitamin A toxicity.
Enzymes involved in lipolysis also mobilize VA in the liver
https://www.sciencedirect.com/science/article/abs/pii/S1388198119300873
In conclusion, HSL participates in vitamin A metabolism in qHSC. Equivalent activities of ATGL and ADPN provide the healthy liver with multiple routes to control circulating retinol levels.
Lipolysis is activated by a large number of things, I assume VA is hydrolyzed out of storage in the liver when serum RBP falls below a certain point, but considering lipolysis is stimulated by many other things, maybe VA is pulled out during times of increased lipolysis without a RBP to capture it?
lil chick and Retinoicon have reacted to this post.
I am sensitive to overly cooked meat, so I worry some of the same compounds might be in charcoal. I have issues with detox.
I am sensitive to overly cooked meat, so I worry some of the same compounds might be in charcoal. I have issues with detox.
Quote from
Armin on July 27, 2021, 11:02 am
Quote from
Kurtis on July 27, 2021, 2:53 am
Maybe lipolysis is a factor here
https://pubmed.ncbi.nlm.nih.gov/1127357/
We suggest that the toxic manifestations of hypervitaminosis A occur when vitamin A circulates in plasma and is presented to membranes in a form other than bound to RBP. Plasma lipoproteins may nonspecificially deliver vitamin A to biological membranes and hence lead to vitamin A toxicity.
Enzymes involved in lipolysis also mobilize VA in the liver
https://www.sciencedirect.com/science/article/abs/pii/S1388198119300873
In conclusion, HSL participates in vitamin A metabolism in qHSC. Equivalent activities of ATGL and ADPN provide the healthy liver with multiple routes to control circulating retinol levels.
Lipolysis is activated by a large number of things, I assume VA is hydrolyzed out of storage in the liver when serum RBP falls below a certain point, but considering lipolysis is stimulated by many other things, maybe VA is pulled out during times of increased lipolysis without a RBP to capture it?
So, a full liver and fat stores of Vitamin A being released "off and on" during lipolysis may be the "leaking" to the tissue membrane process, especially if there isn't even RBP to allow safe transit?
I have noticed that when I lose a bunch of weight that I get flares and symptoms that last for months. Working out has always been associated with these events. Caffeine and other lipolysis compounds may exacerbate the "mini-cycles", of which I have drank for many years, in addition to working out. I have since stopped caffeine usage and nicotine usage.
Quote from
Kurtis on July 27, 2021, 2:53 am
Maybe lipolysis is a factor here
https://pubmed.ncbi.nlm.nih.gov/1127357/
We suggest that the toxic manifestations of hypervitaminosis A occur when vitamin A circulates in plasma and is presented to membranes in a form other than bound to RBP. Plasma lipoproteins may nonspecificially deliver vitamin A to biological membranes and hence lead to vitamin A toxicity.
Enzymes involved in lipolysis also mobilize VA in the liver
https://www.sciencedirect.com/science/article/abs/pii/S1388198119300873
In conclusion, HSL participates in vitamin A metabolism in qHSC. Equivalent activities of ATGL and ADPN provide the healthy liver with multiple routes to control circulating retinol levels.
Lipolysis is activated by a large number of things, I assume VA is hydrolyzed out of storage in the liver when serum RBP falls below a certain point, but considering lipolysis is stimulated by many other things, maybe VA is pulled out during times of increased lipolysis without a RBP to capture it?
So, a full liver and fat stores of Vitamin A being released "off and on" during lipolysis may be the "leaking" to the tissue membrane process, especially if there isn't even RBP to allow safe transit?
I have noticed that when I lose a bunch of weight that I get flares and symptoms that last for months. Working out has always been associated with these events. Caffeine and other lipolysis compounds may exacerbate the "mini-cycles", of which I have drank for many years, in addition to working out. I have since stopped caffeine usage and nicotine usage.
lil chick has reacted to this post.
Quote from
Kurtis on July 27, 2021, 5:16 pm
Quote from
Armin on July 27, 2021, 11:02 am
So, a full liver and fat stores of Vitamin A being released "off and on" during lipolysis may be the "leaking" to the tissue membrane process, especially if there isn't even RBP to allow safe transit?
Maybe, if so blocking lipolysis should reduce toxicity significantly
If true there may also be two phenotypes in VA detox, those who are chronically skinny probably due to lipolysis being constantly activated and those who maintain/gain weight during the diet, with skinny people bearing more inflammation due to more unbound circulating VA
Quote from
Armin on July 27, 2021, 11:02 am
So, a full liver and fat stores of Vitamin A being released "off and on" during lipolysis may be the "leaking" to the tissue membrane process, especially if there isn't even RBP to allow safe transit?
Maybe, if so blocking lipolysis should reduce toxicity significantly
If true there may also be two phenotypes in VA detox, those who are chronically skinny probably due to lipolysis being constantly activated and those who maintain/gain weight during the diet, with skinny people bearing more inflammation due to more unbound circulating VA
Quote from
lil chick on July 27, 2021, 5:49 pm
I've always called myself the amazing shrinking growing woman. Many of my friends and relatives do not do this. (their trend is mostly just a slow creep upwards) I think I have seen underweight listed on VA toxicity lists as a symptom. I have 3 different sizes in my closet all the time, and when a new season begins I always have to try everything on to see what pants and tops I'm wearing now.
I've always called myself the amazing shrinking growing woman. Many of my friends and relatives do not do this. (their trend is mostly just a slow creep upwards) I think I have seen underweight listed on VA toxicity lists as a symptom. I have 3 different sizes in my closet all the time, and when a new season begins I always have to try everything on to see what pants and tops I'm wearing now.
Quote from
Kurtis on July 27, 2021, 7:59 pm
https://academic.oup.com/jcem/article/90/3/1692/2836886
In summary, our experiments indicate that the cortisol response to protein-containing meals originates from an amino acid-dependent activation of the gastrointestinal mucosa. How this signal is reported to the HPA system to stimulate cortisol release is not yet clear. Afferent neurons of the vagus nerve, which is known to enable gut-brain communication, may serve this function. The vagus nerve could also be the target of neuropharmacological agents like cholinergic and adrenergic agonists that have been shown to reinforce the meal-related increase in cortisol release (3, 31). Also, vagal stimulation effectively stimulates HPA secretory activity (32). Alternatively, the intake of proteins and the accumulation of amino acids in the gut might stimulate the release of enteric hormones like cholecystokinin and gastrin-releasing peptide that, in turn, stimulate HPA secretory activity (33, 34).
The amino acid most potently stimulating cortisol release is tryptophan.
High protein -> high tryptophan intake -> increased cortisol secretion -> increased lipolysis...(?)
Maybe gelatin/collagen might be a good protein source to remove the cortisol response from a high protein meal/diet as it has 0 tryptophan in it
https://academic.oup.com/jcem/article/90/3/1692/2836886
In summary, our experiments indicate that the cortisol response to protein-containing meals originates from an amino acid-dependent activation of the gastrointestinal mucosa. How this signal is reported to the HPA system to stimulate cortisol release is not yet clear. Afferent neurons of the vagus nerve, which is known to enable gut-brain communication, may serve this function. The vagus nerve could also be the target of neuropharmacological agents like cholinergic and adrenergic agonists that have been shown to reinforce the meal-related increase in cortisol release (3, 31). Also, vagal stimulation effectively stimulates HPA secretory activity (32). Alternatively, the intake of proteins and the accumulation of amino acids in the gut might stimulate the release of enteric hormones like cholecystokinin and gastrin-releasing peptide that, in turn, stimulate HPA secretory activity (33, 34).
The amino acid most potently stimulating cortisol release is tryptophan.
High protein -> high tryptophan intake -> increased cortisol secretion -> increased lipolysis...(?)
Maybe gelatin/collagen might be a good protein source to remove the cortisol response from a high protein meal/diet as it has 0 tryptophan in it
Quote from
Inger on December 5, 2022, 1:56 pm
Quote from
lil chick on July 26, 2021, 12:44 pm
Sometimes it seems to me that we all show up here with our ideas of what constitutes a good way of life. Let's call that the square peg. Then, the realities of VA detox descend. Let's call that the round hole. And it can be kind of embarrassing when our loved ones see us suddenly change on a dime.
And at least we finally know why all these various detox methodologies were invented (and some of them are ancient). In the past we might have written some of them off as unnecessary or even bad.
I went years, for instance, not using shampoo. Hey, "there was no shampoo in the garden of Eden," I said. Now if, as you say, VA was going to my head... was that smart? During my hot-water rinses, were the VA-ladened oils running down back behind my ears.causing inflammation that I used to have to hit with antibiotic ointment every couple of months or so to stave off infection? Would it have been much better to strip the oils out of my hair and have them go down the drain? Even if that meant replacing those oils?
Another for instance: I can now see how the diabetic I used to talk to at the farmer's market actually felt better on his low-fat diet. At the time, I just thought he was deluded. But he did seem pretty well for a diabetic!
lol.. I have washed my hair with ghassoul mud for more than 10 years.. I love it. I am hoping it absorbs some of the toxins coming out of my scalp.. I have that weird habit of washing my hair every day, and if I dont wash it one day, it really bothers me, I feel not good... like my scalp cant breath! Weird. So I wash my hair every day. Ghassoul is so gentle on the hair it does not make it dry like shampoo does.
Quote from
lil chick on July 26, 2021, 12:44 pm
Sometimes it seems to me that we all show up here with our ideas of what constitutes a good way of life. Let's call that the square peg. Then, the realities of VA detox descend. Let's call that the round hole. And it can be kind of embarrassing when our loved ones see us suddenly change on a dime.
And at least we finally know why all these various detox methodologies were invented (and some of them are ancient). In the past we might have written some of them off as unnecessary or even bad.
I went years, for instance, not using shampoo. Hey, "there was no shampoo in the garden of Eden," I said. Now if, as you say, VA was going to my head... was that smart? During my hot-water rinses, were the VA-ladened oils running down back behind my ears.causing inflammation that I used to have to hit with antibiotic ointment every couple of months or so to stave off infection? Would it have been much better to strip the oils out of my hair and have them go down the drain? Even if that meant replacing those oils?
Another for instance: I can now see how the diabetic I used to talk to at the farmer's market actually felt better on his low-fat diet. At the time, I just thought he was deluded. But he did seem pretty well for a diabetic!
lol.. I have washed my hair with ghassoul mud for more than 10 years.. I love it. I am hoping it absorbs some of the toxins coming out of my scalp.. I have that weird habit of washing my hair every day, and if I dont wash it one day, it really bothers me, I feel not good... like my scalp cant breath! Weird. So I wash my hair every day. Ghassoul is so gentle on the hair it does not make it dry like shampoo does.
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