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Questions on Probiotic and Supplement Studies
Quote from
PJ on July 3, 2023, 6:10 pm
Hey @alexm, I recall you noted in a more recent post that you were trying the Mega SporeBiotic again. Do you have any updates? What really peaks my curiosity about it are the studies that show improved markers of metabolic endotoxemia after just 30 days, without any other dietary changes.
Also, I can't find the post that says what you did to be able to tolerate zinc again. Would you mind sharing that information again?
Hey @alexm, I recall you noted in a more recent post that you were trying the Mega SporeBiotic again. Do you have any updates? What really peaks my curiosity about it are the studies that show improved markers of metabolic endotoxemia after just 30 days, without any other dietary changes.
Also, I can't find the post that says what you did to be able to tolerate zinc again. Would you mind sharing that information again?
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Quote from
Alex on July 3, 2023, 10:06 pm
@pattycake Hi yes I use the Sporebiotic from time to time but not everyday, it seemed to work the best when I used it with T3 and microdose methylene blue. When I combined it with T3 I suddenly felt amazing in the sun and outside, it felt like my dopamine synthesis started working again but when taking those things separately on their own they didn’t produce that effect. Certain Pathogens can impair the VDR receptor (Vitamin D Receptor) and likewise with viruses like EBV. I’ve also heard bacillus in Sporebiotic can lower lactobacillus (a completely different bacteria species to bacillus) levels in the gut if the bacillus overgrows. I do think the Sporebiotic detoxes infections that’s why some people have bad reactions to it.
A Black radish juice supplement helped me tolerate zinc again as it’s a copper antagonist that stimulates bile flow and increases ALDH, but also a strong anti fungal and antibacterial.
If you can’t tolerate zinc suddenly then I think it’s probably because your NA:K ratio (the most important ratio in HTMA) has gone too low and taking zinc alone just lowers the NA:K ratio more. We need copper to fight bacterial and fungal infections so taking zinc when you have a chronic infection is going to make you feel worse as it depletes copper. And chronic infections also lower NA:K ratio. Or when cells become too Low in NAD you can’t absorb zinc properly.
@pattycake Hi yes I use the Sporebiotic from time to time but not everyday, it seemed to work the best when I used it with T3 and microdose methylene blue. When I combined it with T3 I suddenly felt amazing in the sun and outside, it felt like my dopamine synthesis started working again but when taking those things separately on their own they didn’t produce that effect. Certain Pathogens can impair the VDR receptor (Vitamin D Receptor) and likewise with viruses like EBV. I’ve also heard bacillus in Sporebiotic can lower lactobacillus (a completely different bacteria species to bacillus) levels in the gut if the bacillus overgrows. I do think the Sporebiotic detoxes infections that’s why some people have bad reactions to it.
A Black radish juice supplement helped me tolerate zinc again as it’s a copper antagonist that stimulates bile flow and increases ALDH, but also a strong anti fungal and antibacterial.
If you can’t tolerate zinc suddenly then I think it’s probably because your NA:K ratio (the most important ratio in HTMA) has gone too low and taking zinc alone just lowers the NA:K ratio more. We need copper to fight bacterial and fungal infections so taking zinc when you have a chronic infection is going to make you feel worse as it depletes copper. And chronic infections also lower NA:K ratio. Or when cells become too Low in NAD you can’t absorb zinc properly.
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Quote from
Alex on July 3, 2023, 10:11 pm
I’m also currently sprinkling organic dried mixed herbs on my oats and it really helps as an antimicrobial and reducing endoxtoin, I do like putting black radish juice and olive leaf extract on my oats too.
https://www.abelandcole.co.uk/mixed-herbs-organic-steenbergs-18g
I’m also currently sprinkling organic dried mixed herbs on my oats and it really helps as an antimicrobial and reducing endoxtoin, I do like putting black radish juice and olive leaf extract on my oats too.
https://www.abelandcole.co.uk/mixed-herbs-organic-steenbergs-18g
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Quote from
PJ on July 4, 2023, 1:54 pm
@alexm
Thanks. I think I may have overdid the zinc at one time, induced iron anemia. I will look into the black radish juice. My NA:K ratio is probably off too. Did you know that Microbiome Labs has a couple of probiotics with just the keystone strain HU58 including RestorFlora.
Bacillus Licheniformis & Bacillus Indicus HU36™ seem to be the questionable strains and they are only in the MegaSpore.
@alexm
Thanks. I think I may have overdid the zinc at one time, induced iron anemia. I will look into the black radish juice. My NA:K ratio is probably off too. Did you know that Microbiome Labs has a couple of probiotics with just the keystone strain HU58 including RestorFlora.
Bacillus Licheniformis & Bacillus Indicus HU36™ seem to be the questionable strains and they are only in the MegaSpore.
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Quote from
Alex on July 4, 2023, 2:37 pm
@pattycake The overdoing zinc + iron anemia will be because you depleted your copper too much which is needed for iron absorption and utilisation. So in that case black radish juice won’t be helpful and would probably make it worse. Copper is one of the things that raises Na:K ratio.
If those are the carotenoid producing strains I don’t think they are problem as they probably will be rate limiting and producing carotenoids in tiny amounts.
@pattycake The overdoing zinc + iron anemia will be because you depleted your copper too much which is needed for iron absorption and utilisation. So in that case black radish juice won’t be helpful and would probably make it worse. Copper is one of the things that raises Na:K ratio.
If those are the carotenoid producing strains I don’t think they are problem as they probably will be rate limiting and producing carotenoids in tiny amounts.
Quote from
PJ on July 4, 2023, 3:25 pm
@alexm Perhaps your right about the copper, it's practically in everything though so I'm hesitant to think I'm deficient.
I was listening to Kiran Krishnan and when he talks about the benefits from the MegaSporeBiotics first trial, I get pretty leery about supplementing with the HU36 strain (carotenoid). They developed a skin product (serene skin) that includes the HU36 (along with the HU68) strain because of the noticed reduced acne, wrinkles, fine line etc. I think the carotenoids are definitely at work there. I really like Krishnan, he's a great speaker, he seems to be a wealth of information as far as gut health goes. I just can't wrap my head around this though. These spore based strains are supposedly all around us? in the soil, air etc. A "healthy" biome would most likely contain these spores from environment if not from diet, correct? So are we a bit too obsessive about them here?
Your right about detoxing infections. Apparently, "one function of Bacillus Subtilis (the HU68 strain) is its ability to produce nearly 12 strong antibiotics that are potent fighters of opportunistic and harmful bacteria"
@alexm Perhaps your right about the copper, it's practically in everything though so I'm hesitant to think I'm deficient.
I was listening to Kiran Krishnan and when he talks about the benefits from the MegaSporeBiotics first trial, I get pretty leery about supplementing with the HU36 strain (carotenoid). They developed a skin product (serene skin) that includes the HU36 (along with the HU68) strain because of the noticed reduced acne, wrinkles, fine line etc. I think the carotenoids are definitely at work there. I really like Krishnan, he's a great speaker, he seems to be a wealth of information as far as gut health goes. I just can't wrap my head around this though. These spore based strains are supposedly all around us? in the soil, air etc. A "healthy" biome would most likely contain these spores from environment if not from diet, correct? So are we a bit too obsessive about them here?
Your right about detoxing infections. Apparently, "one function of Bacillus Subtilis (the HU68 strain) is its ability to produce nearly 12 strong antibiotics that are potent fighters of opportunistic and harmful bacteria"
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Quote from
PJ on July 4, 2023, 3:33 pm
@alexm also can't help but be a little leary of the IgG supps. containing Bovine Serum Albumin, can't find enough information about supplementing with it. Krishnan is a great promoter though, he make me really want to try some of his products.
Also wanted to note that the HU68 strain is supposed to produce a 40% increase in short-chain fatty acid (SCFA) production!
@alexm also can't help but be a little leary of the IgG supps. containing Bovine Serum Albumin, can't find enough information about supplementing with it. Krishnan is a great promoter though, he make me really want to try some of his products.
Also wanted to note that the HU68 strain is supposed to produce a 40% increase in short-chain fatty acid (SCFA) production!
puddleduck has reacted to this post.
Quote from
Alex on April 12, 2024, 4:09 pm
I think if we could find a probiotic strain that increases bile acid production and excretion then it could be a potentially helpful tool.
I'm unsure about lactobacillus strains, while they're said to be a key part of our normal flora and keeping pathogenic organisms at bay, the fact lactobacillus produces lactic acid is a concern if one wants an efficient metabolism and this could also put strain on the liver when eating sugars.
I know people on here will say strong bile flow is all you need for a healthy gut microbiome and I do agree with that regarding pathogenic organisms, but each of our own gut microbiomes is highly individual and complex, and I don't think we can solely just rely on bile flow to have an optimal gut microbiome. For example our gut microbiome is a biomass that produces 100x more metabolites than our liver.
I think if we could find a probiotic strain that increases bile acid production and excretion then it could be a potentially helpful tool.
I'm unsure about lactobacillus strains, while they're said to be a key part of our normal flora and keeping pathogenic organisms at bay, the fact lactobacillus produces lactic acid is a concern if one wants an efficient metabolism and this could also put strain on the liver when eating sugars.
I know people on here will say strong bile flow is all you need for a healthy gut microbiome and I do agree with that regarding pathogenic organisms, but each of our own gut microbiomes is highly individual and complex, and I don't think we can solely just rely on bile flow to have an optimal gut microbiome. For example our gut microbiome is a biomass that produces 100x more metabolites than our liver.
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