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I think that VA toxicity leads to becoming crooked. Crooked fingers, shoulders bent forward, hands and feet curled inward crooked teeth etc. I think it is interesting that Price believed that VK was super important to the arches of the body, and perhaps having high VA is the opposite of that
Exactly @lil-chick.
This is extremely interesting @Arena!
I wonder how to do this IH (isocapnic hyperpnoia) in pranayama terms. How can we do this respiration without the machine? Do you have an idea? Or @dino?.
The article you quote seems to answer the question about vA excretion I have been wondering about all along.
@naveen: Roughly 2/3 of detoxification happens through the lungs (if they are working well, more if you practice specific breathing methods as outlined here). I don't know for retinol but I don't see any reason it should not be so as well.
@lil-chick: Yes, posture is very important. The Five Tibetan Rites are a good way to improve your posture.
@are & @ourania: I don't think it is possible to achieve it without external "mechanical help" since I don't see how you could increase "air" without decreasing CO2 at the same time.
An important thing here is that they give a gas containing 5,5% CO2. This is much more than what average people have in their blood and it will basically force the extra-oxygen to go directly and deeply within tissues and brain; this is what works/heals.
The best method to achieve this rapidly is Wim Hof. If you do several "rounds" of Wim Hof breathing you will achieve the same result as the one they do in the study. To be clear, I think you cannot achieve isocapnic hyperpnoia by natural means but you can certainly achieve the same "result" (forced oxygenation of tissues and brain) by repeating Wim Hof a few times in a row.
@Arena , maybe you are detoxing more retinol through breathing ( during exercise ) and exercise can be an agitator
I completely agree with you , there can be other causes too . I don’t really understand the never ending detox . I can understand very slow improvements ( as Grant is still improving in his health ) maybe there are deficiencies to be addressed .
@are I think about the process of detox as a series of 6 steps. At each step something can be going slowly & cause a bottleneck. So if you agitate a lot of vA out of the liver - vigorous exercise will do this - then you have an increased amount of vA to process & excrete. If one of your steps is running slowly then this can result in an accumulation. Accumulation = symptoms.
ALDH enzyme (retinaldehyde into retinoic acid) is one of the steps that is very prone to being slowed down in some people (many reasons). Aldehyde accumulation is a definite symptom producer. I have been looking at this recently as I think it’s an issue for me. This may not be your problem but I think it could be worth considering as there are many things that can help. Summary: If you agitate you need a smooth running detox system or you can be prone to accumulation.
Won’t too much soluble fibre or charcoal do the same ?
@are 😀 now that is the question!
1. Reduce agitators to a level that doesn’t produce symptoms. You only want the amount leaving storage that the various processing stages & excretion capabilities can cope with. If you overwhelm them you get accumulation. Accumulation = symptoms.
2. Directly help aldehyde accumulation/slow ALDH (if this is the problem - there could be a bottleneck elsewhere). I’ll link a paper here shortly. There are also lots of suggestions on Garrett Smith’s mighty network. The idea is not to increase enzymes but to ‘not slow them down’ too much. One thing that I’ve been working on recently (still a theory) is gut dysbiosis causing increased hydrogen sulphide production which slows ALDH. ALDH is very susceptible to sulphur problems (the drug Antabuse uses this fact).
3. Increase excretion to make sure the bottleneck isn’t here. Bile (soluble fibre, other binders), urine, sweat & breath.
That’s the plan I go by! It’s all still work in progress. As you say we are all learning. Hth.
One of my guesses is that the inside of my nose is very much like the outside: prone to become all red and sore. Non-resilient.
Five people walked in a stiff wind by the coast of New England Sunday. Only one got wind burn. If I jog in the cold (mouth breathing) I can loose my voice. I couldn't follow Tim's tooth protocol because my gums and mouth got sore.
My guess is that this "delicacy of tissues" is slowly, slowly resolving. My surfaces are trying to become stronger. But they aren't all the way there yet.
I think @JAJ did such a nice job with that aldehyde info, thanks for that.
I suspect there may just be some VA coming down in nose mucus. It itches, it gets sore. I swipe the area with a wet tissue sometimes, or clean the nostril with wet Q-tip.
We produce hundreds of milligrams of formaldehyde each day from fruit, vegetable and legume consumption.
pectin -> methanol -> formaldehyde -> formic acid
Even if we avoid alcoholic beverages, ADH enzymes need to detoxify hundreds of milligrams of ethanol, acetalaldehyde, methanol and formaldehyde each day.
If someone has Hypervitaminosis A they may have at most about 1 gram of retinol stored in their liver. This amount takes years to deplete. In other words very little enzymatic action is needed in comparison to alcohol metabolism and it is very unlikely that enzymatic action is the limiting factor in vA depletion.
retinol -> retinaldehyde -> retinoic acid
While ADHs and ALDHs with broad specificity can catalyse these reactions we have specific retinol dehydrogenases and retinaldehyde dehydrogenases to do so.
Scientists sometimes misuse the term "retinol dehydrogenase" when describing an ADH that has broad specificity that includes retinol oxidation but there are specific retinol dehydrogenases.
Occasionally, the literature refers to retinol dehydrogenase as an enzyme that oxidizes retinol in general, such as class IV alcohol dehydrogenase (ADH4), which reportedly is the most efficient retinol oxidation in the human alcohol dehydrogenase (ADH) family.[3][4]
All-trans-retinol dehydrogenase:
https://enzyme.expasy.org/EC/1.1.1.105
vs
Alcohol dehydrogenase
https://enzyme.expasy.org/EC/1.1.1.1
(Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol.)
Retinal dehydrogenase:
https://enzyme.expasy.org/EC/1.2.1.36
vs
Formaldehyde dehydrogenase:
https://enzyme.expasy.org/EC/1.2.1.46
vs
Acetaldehyde dehydrogenase:
https://enzyme.expasy.org/EC/1.2.1.10
The primary source of toxicity in Hypervitaminosis A is elevated levels of the hormone retinoic acid. The main benefit of depleting retinol stores is the lowering of retinoic acid levels. I'm skeptical but assuming we could significantly increase levels of ADH and assuming ADH levels had a significant affect on retinoic acid production it would actually be an undesirable outcome, especially for people that are detoxing from Accutane.
My understanding is that a significant amount of retinoic acid is produced locally through the body, some chemicals like caffeine may slow down enzymatic conversion but ultimately the only solution is depletion of liver retinol stores.
As @jaj has pointed out in (1) we don't want more retinoic acid being produced than necessary. However for the reasons above I see Smith's ADH theory as highly flawed.