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Vision

In a consumer-directed publication, Stephen Sinatra (M.D.) observes, “Research has shown that high doses of synthetic beta-carotene—the kind found in many popular brands—may actually increase your risk for lung cancer. Because at high levels it can become prooxidative—exactly the opposite of what you want…I’ve seen harmful effects (such as serious vision loss) in people who have taken up to 80,000 IU of beta-carotene per day. The bottom line is: Less is more when it comes to beta-carotene. To be safe I recommend between 12,500 and 25,000 IU of beta-carotene per day from food sources such as carrots” [39]

The Truth About Vitamins in Nutritional Supplements

[39] Sinatra S. Consumer Alert: Don’t Touch this Button, 2003:34-35

 

 

https://pubmed.ncbi.nlm.nih.gov/6502269/

This article  may have been previously posted.  Sorry to repeat if so.  

 

Am wondering if retina damage can eventually be improved.  Retina regeneration seems to be impossible unless  you’re a Zebrafish.  

DWL 

 

https://pubmed.ncbi.nlm.nih.gov/6502269/

Quote from DWL on December 13, 2020, 4:26 pm

 

 

https://pubmed.ncbi.nlm.nih.gov/6502269/

This article  may have been previously posted.  Sorry to repeat if so.  

 

Am wondering if retina damage can eventually be improved.  Retina regeneration seems to be impossible unless  you’re a Zebrafish.  

DWL 

 

https://pubmed.ncbi.nlm.nih.gov/6502269/

Sometimes when I think about the slowness of healing on lowered VA , I wonder if some damage is permanent.   Hey, just NOT GETTING WORSE" is still an amazing benefit (although maybe difficult to identify and accept)... but a lot better than eventual loss of vision or death etc.   And there is usually room for hope, our bodies are amazing.

I agree totally, lil chick.  Thanks for your reply. 

I don't know if I have any retina damage or what it entails, but my eyesight is improving on almost a weekly basis when I'm very very very strict with my diet.

I feel that my far vision is getting better, night might be worse, close vision about the same (starting to need readers), slow to focus and slow to react to light/dark.  I wear glasses the bare minimum to make my eyes work-- just for tiny type and for driving.  Dark glasses are sometimes essential in a high contrast or flashing situation.

I had perfect vision until around 17 years ago, and I wouldn't be surprised if my eye issues are just age and VA.  (I was born with great vision and went 40 years without glasses)

Here’s a good YouTube video that clearly state that Vitamin A has a part in causing macular degeneration.  Of course stopping Vitamin A consumption is not considered in treating the disease. 

 

 

dSWL 

 

 

 

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lil chick

Hi @dswl,

Thanks for sharing that video. Very telling; and I think the answer is basically staring them in the face. But, with the deeply entrenched belief that vision is a chemical reaction (but it's only so for vision at night BTW, and with no explanation for how we see in daylight) they fail to see what they are looking at.

AMD = slow accumulation of fluorescent retinal based lipofuscin in the retinal pigment epithelium

 

DWL and lil chick have reacted to this post.
DWLlil chick

It appears that you are correct, Grant.  Once  lipofuscin forms it  appears almost impossible to eliminate, but I’m giving it a good try!!  Thanks for the input.  

 

 

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lil chick

This is a really interesting paper documenting the lipofuscin accumulation with age.

Fundus Autofluorescence and RPE Lipofuscin in Age-Related

Macular Degeneration

https://pubmed.ncbi.nlm.nih.gov/25774313/

 

 

Although there’s been a massive incidence rate increase in AMD over the last century, and AMD was virtually non-existent in the 1800’s, the authors of this paper claim that genetics accounts for 45% to 71% of cases. The lipofuscin particles contain various bisretinoids (based on two conjuncated retinal molecules).

They state that since the two conjuncated retinal molecules are tied up that they cannot be used in the visual cycle, and are also, of course, toxic. 

Fluorescence is used to measure the concentration and progressive build up of the lipofuscin particles within the retinal pigment epithelium (RPE) cells.  Of course, the accumulation of the lipofuscin particles is not limited to just the RPE cells, it is happening in many other epitheliums all over the body and in the brain too.

This paper is quite good, but a bit long.  Here’s a few particularly insightful statements:

This apparent incongruity has been attributed to abnormal RPE cells that have lost melanin while accumulating excessive levels of lipofuscin due to accelerated rates of outer segment phagocytosis [84,105].

 

Mechanistically, mishandling of retinaldehyde, the precursor of lipofuscin, is known to lead to elevated bisretinoid formation in photoreceptor cells [111] and compromised photoreceptor cells may not be able to provide the energy needed for reduction of retinaldehyde to the non-reactive alcohol form.

 

At any given time, the lipofuscin in RPE that is recorded by SW-AF may consist of only some portion of the fluorescent material that has been accumulated over a life-time.

 

So, it’s no wonder why it takes so long to reverse our chronic disease conditions.

 

 

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Orion