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Vitamin A and sleep study
Quote from puddleduck on December 5, 2019, 4:15 pm@bludicka. Here’s a study B1 and Parkinson’s:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828997/
Thanks. Befor low VA diet, I often felt I had too much lactic acid in the body and in the brain (I stopped probiotics and fermented foods but it didn't help) and I found out that there is a link between B1 and lactic acid and B1 helped me almost immediately with this lactic acid feeling and headaches. At this time I was already serious VA toxic, I began to suspect that something was wrong with me. VA toxicity was the cause because it inhibits B1 in the brain and then lactic acid accumulates.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388689/
Too much lactic acid can cause chronic fatigue, fibromyalgia symptoms, brain fog, slurred speech...(I had lactic acid problems in the past because of SIBO and some probiotics strains but it quickly improved if I stopped taking probiotics but VA toxicity caused almost permanent lactic acid feeling)
https://www.healthrising.org/blog/2016/03/01/lactate-fibromyalgia-chronic-fatigue-syndrome/
I was looking for lactate accumulation in the brain from thiamine deficiency:
https://www.ncbi.nlm.nih.gov/pubmed/15573405
" Metabolic impairment due to thiamine deficiency thus results in increased glycolysis, increased LDH immunolabeling of neurons and astrocytes and increased de novo synthesis of lactate in brain regions vulnerable to thiamine deficiency. These results are consistent with the notion that focal lactate accumulation participates in the worsening of neurologic symptoms in thiamine-deficient patients."
All of that makes a lot of sense @bludicka. I really appreciate your sharing this stuff with me, and I look forward to reading all the links this afternoon. It’s reassuring (as well as CRAZY EXCITING 😁) to see all these clues pointing in the same direction (VA toxicity/B1 deficiency/lactic acid in the brain, which is what Jarred Younger was observing in the brains of CFS patients).
I’m glad you told me about the probiotic thing right now, because my Mom just sent me this fancy probiotic she found (hoping it would help my CFS) and I was considering taking it, but have held off because I haven’t researched it yet (some people with CFS say probiotics help them, but they never did for me). I will check the strains against those in the article you provided, as I do get several of those symptoms.
I’ve read somewhere (it might’ve been Health Rising), about a study or something that indicated CFS was a sort of “pre-parkinson’s” (I will have to try and find that source, because I might have misunderstood it). I watched my Grandmother die of Parkinson’s (she was in her 80s), and I now have two family friends in my parent’s age group who have been diagnosed with that disease (only in their mid 50s or early 60s).
It’s so emotional to see that progress towards understanding Parkinson’s (and CFS, too) is being made, and that we MIGHT even have the knowledge to improve people’s quality of life right NOW... I’m floating on a cloud. ☁️🌈☀️
Regarding probiotics and lactic acid production, the most problematic for me was Lactobacillus delbrueckii subsp. bulgaricus - it was a separate probiotic+ S. thermophilus and then acidophilus strains. These were problematic for histamine too.
The best for me were bifidobacterium strains and you can buy d-lactate free probiotics:
https://www.customprobiotics.com/d-lactate-free-probiotics.html (with this I have a good experience)
Interestingly, bifidobacterium infantis is the one of the most abundant species in the bodies of breast-fed babies. This is because B. infantis is passed onto a newborn through breast milk - and these are the most tolerated probiotics. But Lactobacillus delbrueckii subsp. bulgaricus is not naturally present in the human digestive tract - this is only transient bacteria and mostly used for yoghurt production.
Good info:
https://www.fixyourgut.com/why-supplementing-with-probiotics-may-make-you-ill-part-4-d-lactate/