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The relationship between Vitamin A, Copper, Ceruloplasmin and Thyroid
Sorry but it’s weird no one in here speaks about the relationship between Vitamin A, Copper, Thyroid and Ceruloplasmin. It’s like everyone got so scared from you know whose views about copper being a toxin so no one seems to be aware of this stuff or discusses their involvement with Vitamin A metabolism.
Me: How does vitamin A work with the thyroid and ceruloplasmin?
Chat GPT: Vitamin A plays an important role in the regulation of thyroid hormone metabolism and function, and it also affects the synthesis and activity of ceruloplasmin.
Thyroid hormones are essential for maintaining metabolic homeostasis, and vitamin A plays a crucial role in their regulation. In particular, vitamin A is required for the conversion of the inactive thyroid hormone, thyroxine (T4), to the active form, triiodothyronine (T3), which is responsible for regulating metabolism in the body. Vitamin A deficiency has been shown to impair the conversion of T4 to T3, resulting in reduced metabolic activity and energy expenditure.
Ceruloplasmin is a copper-containing protein that plays a role in iron metabolism and oxidation. Vitamin A has been shown to affect ceruloplasmin synthesis and activity by regulating the expression of genes involved in copper metabolism. Specifically, vitamin A deficiency has been shown to impair the synthesis of ceruloplasmin, resulting in reduced copper metabolism and impaired iron mobilization.
In summary, vitamin A plays an important role in regulating thyroid hormone metabolism and function, as well as in affecting the synthesis and activity of ceruloplasmin. Maintaining adequate levels of vitamin A is essential for proper thyroid function and copper metabolism.
Me: What is the relationship between vitamin A and copper?
Chat GPT: Vitamin A and copper are both essential nutrients required for many physiological processes in the body, and there is a complex relationship between them.
On one hand, vitamin A is required for the proper utilization of copper in the body. Vitamin A is involved in the regulation of copper metabolism, and it helps to facilitate the absorption and transport of copper in the body. Vitamin A deficiency can impair the utilization of copper and lead to copper deficiency.
On the other hand, copper is required for the proper metabolism and function of vitamin A. Copper is an essential cofactor for the enzyme that converts retinol (the storage form of vitamin A) to retinal (the active form of vitamin A). Copper deficiency can impair this conversion and lead to vitamin A deficiency.
In summary, vitamin A and copper have a complex and interdependent relationship in the body. Maintaining adequate levels of both nutrients is important for proper physiological function.
I saw this old post the other day that got me thinking about this:
Helen/Gbold: “by the way, thyroid hormones deplete vitamin A stores. within 3 weeks. since it increases the production of retinoic acid. to supply ceruloplamin
obviously vitamin A is not a toxin.
but most of ray peat forum ate tons of it, along with liver ( COPPER)) and of course got toxic) when ray peat told them that it only should be taken with THYROID.”
How does copper help with the metabolism of Vitamin A? I note that Vitamin A and copper move inversely in the liver so as one goes up, the other goes down.
Chat GPT: Copper and Vitamin A have an inverse relationship in the liver and their metabolism are closely linked. Some of the ways in which copper helps with the metabolism of Vitamin A include:
- Copper is necessary for the activity of an enzyme called ceruloplasmin, which is involved in the metabolism of Vitamin A. This enzyme helps to convert Vitamin A into its active form, retinoic acid, which is needed for proper vision and cell growth.
- Copper also plays a role in the metabolism of Vitamin A in the liver. Copper is involved in the regulation of the activity of a protein called retinol-binding protein (RBP), which is responsible for the transport of Vitamin A in the blood.
- Copper helps to maintain the balance of Vitamin A in the liver by regulating the activity of the protein responsible for the storage and release of Vitamin A.
- Copper also plays a role in the breakdown of Vitamin A in the liver, by participating in the process of detoxifying and excreting excess Vitamin A.
It’s important to note that Copper and Vitamin A work together to maintain proper Vitamin A levels in the body and their balance is important for the proper functioning of various bodily functions. Consult with a healthcare professional for personal advice and for treatment if experiencing any Vitamin A or Copper deficiency or excess.
@joe like what do you mean?
While I have not looked much into copper yet, nor do I know what Voldemort is saying about other than what I've learned here, I would advice caution in using ChatGPT as a source for anything since it's essentially just a search engine. While it's great for finding studies and various obscure metabolites as an example, it commands about as much authority as Wikipedia as far as sources are concerned.
@joe Based on everything that was mentioned above how could it be that Vitamin A is a toxin. Let’s see a thyroid panel of people who have Vit A toxicity, let’s see their ceruloplasmin level, let’s see thier iron panel, let’s see their oxidation rate on a HTMA, let’s see their mineral levels, let’s see a Gut microbiome test for pathogens, there will always be some issue somewhere which is altering their metabolism negatively. Ray Peat said most people have subclinical hypothyroidism. Funny that when my gallbladder stopped working last year I had low T3 levels, then 5 months later I developed Vit A toxicity after overeating carrots and butternut squash. Bile acids stimulate the synthesis of T3. Vitamin A deficiency has been shown to impair the conversion of T4 to T3, resulting in reduced metabolic activity and energy expenditure.
If someone is a slow oxidiser on an HTMA like 80% of people are then they shouldn’t be intaking high Vit A.
Glyphosate chelates Copper to a Ph of 0 and makes it unusable and Glyphosate shuts down the liver’s metabolism of Vit A and chelates others minerals like magnesium, zinc, manganese, sulfur. Glyphosate replaces glycine in the body which is needed to synthesise bile. Pathogens and viruses lower NAD levels which is needed for ALDH. Most pathogens produce acetylaldehyde which will burden ALDH and ADH. Then we have all the other things on top of that impair Vit A metabolism.
While Grant and Mawson made a great discovery with this whole thing, they are not looking into what is the root cause of this Vitamin A toxicity issue. And if you see Vitamin A as only a toxin then you can’t do this.
It's only ever accurate in that it regurgitates current consensus. Like Wikipedia, it's a great place to start, but since the information provided is in constant flux, you're going to need a static study to base your claims upon. As for ChatGPT, it's a great tool for demonstrating just how much our current understanding is based on assumptions. If you keep pestering it for ever more detail, you'll get to the point where consensus claims are based on nothing but guesswork.
I can only agree with what Tobias says. ChatGTP is more regurgitating, there's not much originality of thought to be expected. There's a lot of potential for abuse. Whatever narrative is being promoted in the media, ChatGTP will not deviate from it. So it exudes authority when there is no justification for it, potentially misleading users. AI is the perfect tool for any totalitarian state. Beware!
@hermes Either way Gbolduev was some crazy genius, and his post from a few years ago confirms some of the ChatGPT info about the Vit A, Ceruloplasmin and thyroid connection.
If you look at what the liver contains, it only really contains two “nutrients” in insane amounts (relative to muscle meat). Vitamin A and Copper.
Why does the liver have such large amounts of these two compounds?