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"Vitamin" A(as a hormone) directly upregulates ACE2 expression, leading to increased risks of SARS-CoV2 infection on initial exposure
Quote from Arena on June 2, 2021, 7:28 am@ggenereux2014 you might find Bret Weinstein interesting, he is an evolutionary biologist, and he has long been talking about Ivermectin in relationship with COVID, and this came out yesterday: COVID, Ivermectin, and the Crime of the Century: DarkHorse Podcast with Pierre Kory & Bret Weinstein - YouTube
@wavygravygadzooks do you know of him and his contribution to the work on telomeres and how Nobel laureate Carol Greider stole his work? very interesting!
Hi @are,
I think that if ivermectin is proven and accepted to work for covid, it won't be long before some smart researchers test it for other viruses, say such as the measles, HIV etc. I suspect that it is going to be just as effective there too; and that could bring down the entire vaccine industry..... the pharma boys will never allow that to happen.
I think if there are OTC therapies that work, then you lose your "emergency use authorization" of a partially tested gene therapy shot.
@are
I've been following Bret for a while now. I think he and his wife are excellent scientists who are setting a public example of how to interpret data without drawing overstated conclusions. Just like every other person out there, they certainly don't know everything, but they do know how to properly digest information and draw appropriate conclusions from it. If you want to learn how to think properly, I highly recommend watching their podcasts! I find them to be the most reliable people for getting objective information about Covid without any spin on it, which is initially why I started following them.
I hadn't heard that somebody had "stolen" Bret's idea though... I'll have to look into that.
@ggenereux2014 if Ivermectin is ramping up the production of CYP3A4 what else is?
We have stopped ingesting retinol and carotenoids. We have stopped eating stuff neutralizing the effects of CYP3A4. The next step would be to try to ramp up its production. Ivermectin is banned, maybe there is another way?
Hi @ourania,
I don’t think Ivermectin is completely banned. It is just being aggressively blocked as a treatment option for COVID. Clearly, the medical establishment does not want any potential competition for their vaccines.
You might be able to still get Ivermectin for non-covid reasons. But, I have no idea if it is beneficial for us or not. That’s still pretty much speculation.
Sorry, I don’t have any other suggestions.
Also, if I understand it correctly, Ivermectin is not actually ramping up the production of the CYP3A4 enzyme; rather it is a substrate used by that CYP3A4 enzyme to assemble or disassemble other molecules used in catabolizing RA.
Thank you @ggenereux2014
COVID is recognized by immune system through TLR4 Receptor(early/primary recognition):
https://www.nature.com/articles/s41429-021-00430-5/figures/1
Retinol(as all antibiotics do) dose-dependently inhibits TLR4(and other TLRs too):
https://pubmed.ncbi.nlm.nih.gov/23086657/
However, it has not been fully understood how retinol regulates TLR activation in macrophages. Our results showed that retinol suppressed the expression of various inflammatory cytokines in bone marrow-derived macrophages stimulated with ligands of TLR2, TLR3, or TLR4.
Vitamin A deficiency increases inflammatory responses
https://pubmed.ncbi.nlm.nih.gov/8972739/
The authors studied the influence of vitamin A deficiency on immediate and delayed type hypersensitivity as well as granulocyte-mediated inflammatory reactions in vitamin A depleted and control rats. The number of circulating leucocytes was 43% higher in the vitamin A deficient than in the control animals. The leucocytosis was a result of a general increase of white blood cells and was not due to an increase in one particular type. The ratio between CD4+ and CD8+ T cells was unchanged. The vitamin A deficient rats had a four times higher T-cell proliferative response and a two times higher interferon-gamma production in vitro than the control animals. In accordance, the DTH reaction was consistently higher in the vitamin A deficient rats. The granulocyte dependent inflammation, induced by olive oil injection, was also strongly enhanced in the vitamin A deficient rats compared with the controls. In addition, the spontaneous release of nitric oxide from the peritoneal phagocytes was five times higher in the vitamin A deficient animals. The number of peritoneal mast cells was about one and a half times higher in the vitamin A deficient than in the control animals. The density of IgE-receptors on the mast cells, the IgE receptor occupancy and the histamine release from the mast cells did not differ between the groups, however. The vitamin A deficient immunized rats displayed a consistently stronger immediate skin reaction after intracutaneous antigen injection than the immunized control rats, despite lower IgE antibody levels. The skin reaction after intracutaneous injection of histamine was also significantly greater in the deficient animals. Despite the stronger reaction to antigen and histamine, the passive cutaneous anaphylaxis reaction was lower in the vitamin A deficient rats. In conclusion the study shows that vitamin A deficiency aggravates the clinical manifestations of inflammatory reactions.
Nitric oxide a possible treatment for COVID-19, study finds
https://www.sciencedaily.com/releases/2020/10/201002111724.htm
Researchers at Uppsala University have found that an effective way of treating the coronavirus behind the 2003 SARS epidemic also works on the closely related SARS-CoV-2 virus, the culprit in the ongoing COVID-19 pandemic. The substance concerned is nitric oxide (NO), a compound with antiviral properties that is produced by the body itself. The study is published in the journal Redox Biology.
"To our knowledge, nitric oxide is the only substance shown so far to have a direct effect on SARS-CoV-2," says Åke Lundkvist, a professor at Uppsala University, who led the study.
COVID-19: Nitric oxide shows promise as antiviral treatment
https://www.medicalnewstoday.com/articles/covid-19-nitric-oxide-shows-promise-as-antiviral-treatment
Nitric oxide as a therapeutic option for COVID-19 treatment: a concise perspective
https://pubs.rsc.org/en/content/articlelanding/2021/nj/d0nj03823g
AUM
Nitric Oxide is released through TLR4 receptor stimulation both with covid proteins & other agonists like endotoxins. Retinol antagonizes the receptor.
https://www.nature.com/articles/s41422-021-00495-9
Previous in silico studies predicted cell surface TLRs, especially TLR4, are most likely to be involved in recognizing molecular patterns, probably spike protein, from SARS-CoV-2 to induce inflammatory responses
https://pubmed.ncbi.nlm.nih.gov/23086657/
Our results showed that retinol suppressed the expression of various inflammatory cytokines in bone marrow-derived macrophages stimulated with ligands of TLR2, TLR3, or TLR4.
https://pubmed.ncbi.nlm.nih.gov/20388086/
...TLR4 mediates endotoxin-induced release of nitric oxide and TNF...